Implications of a highly divergent dengue virus strain for cross-neutralization, protection, and vaccine immunity.

Animals Antibodies, Viral / blood Antigens, Viral / immunology Broadly Neutralizing Antibodies / blood Cross Protection Cross Reactions Dengue / immunology Dengue Vaccines / immunology Dengue Virus / genetics Female Genotype Humans Immunization, Passive Immunogenicity, Vaccine Macaca mulatta Male Mice Mice, Inbred C57BL Mice, Transgenic Serogroup Viral Envelope Proteins / chemistry
antibody dengue divergent genotype neutralization pathogenesis protection serotype

Journal

Cell host & microbe
ISSN: 1934-6069
Titre abrégé: Cell Host Microbe
Pays: United States
ID NLM: 101302316

Informations de publication

Date de publication:
10 11 2021
Historique:
received: 20 05 2021
revised: 15 08 2021
accepted: 10 09 2021
pubmed: 6 10 2021
medline: 28 1 2022
entrez: 5 10 2021
Statut: ppublish

Résumé

Although divergent dengue viruses (DENVs) have been isolated in insects, nonhuman primates, and humans, their relationships to the four canonical serotypes (DENV 1-4) are poorly understood. One virus isolated from a dengue patient, DKE-121, falls between genotype and serotype levels of sequence divergence to DENV-4. To examine its antigenic relationship to DENV-4, we assessed serum neutralizing and protective activity. Whereas DENV-4-immune mouse sera neutralize DKE-121 infection, DKE-121-immune sera inhibit DENV-4 less efficiently. Passive transfer of DENV-4 or DKE-121-immune sera protects mice against homologous, but not heterologous, DENV-4 or DKE-121 challenge. Antigenic cartography suggests that DENV-4 and DKE-121 are related but antigenically distinct. However, DENV-4 vaccination confers protection against DKE-121 in nonhuman primates, and serum from humans immunized with a tetravalent vaccine neutralize DENV-4 and DKE-121 infection equivalently. As divergent DENV strains, such as DKE-121, may meet criteria for serotype distinction, monitoring their capacity to impact dengue disease and vaccine efficacy appears warranted.

Identifiants

DOI: 10.1016/j.chom.2021.09.006 PMID: 34610295 PMC: PMC8595868
pubmed: 34610295
pii: S1931-3128(21)00422-4
doi: 10.1016/j.chom.2021.09.006
pmc: PMC8595868
mid: NIHMS1741865
pii:
doi:

Substances chimiques

Antibodies, Viral 0
Antigens, Viral 0
Broadly Neutralizing Antibodies 0
Dengue Vaccines 0
Viral Envelope Proteins 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

1634-1648.e5

Subventions

Organisme : NIAID NIH HHS
ID : R01 AI125202
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI073755
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI164653
Pays : United States
Organisme : NIAID NIH HHS
ID : R21 AI145012
Pays : United States
Organisme : NIAID NIH HHS
ID : 75N93019C00062
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM007200
Pays : United States
Organisme : NIAID NIH HHS
ID : T32 AI007163
Pays : United States
Organisme : NIAID NIH HHS
ID : F30 AI152327
Pays : United States
Organisme : NIAID NIH HHS
ID : U01 AI115577
Pays : United States
Organisme : NIH HHS
ID : U42 OD021458
Pays : United States
Organisme : NIH HHS
ID : P40 OD012217
Pays : United States

Informations de copyright

Copyright © 2021 Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of interests M.S.D. is a consultant for Inbios, Vir Biotechnology, and Carnival Corporation and is on the scientific advisory boards of Moderna and Immunome. The Diamond Laboratory has received unrelated funding support in sponsored research agreements from Moderna, Vir Biotechnology, and Emergent BioSolutions. The Vasilakis laboratory has received unrelated funding support in sponsored research agreements from Public Health Vaccines.

Références

J Virol. 2013 Dec;87(24):13729-40
pubmed: 24109224
Mol Syst Biol. 2011 Oct 11;7:539
pubmed: 21988835
Emerg Infect Dis. 2008 Mar;14(3):502-4
pubmed: 18325274
Proc Natl Acad Sci U S A. 2019 Jan 2;116(1):227-232
pubmed: 30518559
Am J Trop Med Hyg. 2001 Nov;65(5):405-13
pubmed: 11716091
J Infect Dis. 1973 Jul;128(1):7-14
pubmed: 4198027
PLoS Pathog. 2013;9(12):e1003761
pubmed: 24348242
Bacteriol Rev. 1950 Sep;14(3):225-32
pubmed: 14772197
Genome Announc. 2017 Jul 20;5(29):
pubmed: 28729258
Cell Rep. 2020 Oct 6;33(1):108226
pubmed: 33027653
J Virol. 2017 Feb 14;91(5):
pubmed: 28031369
Immunol Rev. 2015 Nov;268(1):340-64
pubmed: 26497532
Cell Host Microbe. 2019 Nov 13;26(5):601-605.e3
pubmed: 31676304
PLoS Pathog. 2017 Feb 16;13(2):e1006178
pubmed: 28207910
Virology. 2006 Mar 1;346(1):53-65
pubmed: 16325883
J Infect Dis. 2005 Mar 1;191(5):710-8
pubmed: 15688284
PLoS One. 2013;8(1):e54220
pubmed: 23342105
PLoS Pathog. 2008 May 09;4(5):e1000060
pubmed: 18464894
Science. 2013 Oct 25;342(6157):415
pubmed: 24159024
JAKSTAT. 2014 Jan 1;3(1):e27715
pubmed: 24778924
Trends Microbiol. 2014 Mar;22(3):138-46
pubmed: 24468533
J Hyg (Lond). 1982 Dec;89(3):355-64
pubmed: 7153506
J Infect Dis. 2016 Oct 1;214(7):986-93
pubmed: 26984144
Parasit Vectors. 2017 Aug 31;10(1):406
pubmed: 28859676
Viruses. 2011 Sep;3(9):1562-608
pubmed: 21994796
PLoS Negl Trop Dis. 2011 Aug;5(8):e1251
pubmed: 21829739
J Infect Dis. 2002 May 1;185(9):1213-21
pubmed: 12001037
Antiviral Res. 2016 Apr;128:7-19
pubmed: 26794397
Infect Genet Evol. 2018 Aug;62:279-295
pubmed: 29704626
J Gen Virol. 1989 Jan;70 ( Pt 1):37-43
pubmed: 2543738
PLoS Negl Trop Dis. 2018 Feb 9;12(2):e0006209
pubmed: 29425203
Science. 2004 Jul 16;305(5682):371-6
pubmed: 15218094
Vaccine. 2015 Dec 10;33(50):7051-60
pubmed: 26478201
Emerg Infect Dis. 2016 Dec;22(12):2146-2148
pubmed: 27869598
PLoS Negl Trop Dis. 2017 May 15;11(5):e0005554
pubmed: 28505154
Nature. 2013 Apr 25;496(7446):504-7
pubmed: 23563266
Front Immunol. 2014 Sep 24;5:452
pubmed: 25309540
J Virol. 2010 Sep;84(18):9227-39
pubmed: 20592088
Am J Trop Med Hyg. 1990 Feb;42(2):179-84
pubmed: 2316788
Lancet Infect Dis. 2020 Jul;20(7):839-850
pubmed: 32220283
NPJ Vaccines. 2017 Jul 10;2:19
pubmed: 29263875
Virology. 2008 Oct 25;380(2):296-303
pubmed: 18774583
Hum Vaccin. 2006 Jul-Aug;2(4):167-73
pubmed: 17012875
Nat Immunol. 2015 Feb;16(2):170-177
pubmed: 25501631
Infect Genet Evol. 2003 May;3(1):19-28
pubmed: 12797969
Virology. 1997 Apr 14;230(2):244-51
pubmed: 9143280
J Virol. 2006 Dec;80(24):12149-59
pubmed: 17035317
Curr Opin Virol. 2020 Aug;43:50-58
pubmed: 32950933
Science. 2010 May 7;328(5979):745-8
pubmed: 20448183
J Infect Dis. 2000 Jan;181(1):2-9
pubmed: 10608744
J Theor Biol. 2001 Sep 7;212(1):57-69
pubmed: 11527445
Nat Methods. 2020 Mar;17(3):261-272
pubmed: 32015543
PLoS Negl Trop Dis. 2012;6(8):e1760
pubmed: 22880140
Curr Protoc Microbiol. 2013 Nov 05;31:15D.3.1-15D.3.18
pubmed: 24510289
Front Immunol. 2014 Apr 10;5:151
pubmed: 24782859
Antiviral Res. 2017 Aug;144:44-47
pubmed: 28529000
Nat Rev Microbiol. 2011 Jun 13;9(7):532-41
pubmed: 21666708
Cell Rep. 2018 Oct 30;25(5):1214-1224
pubmed: 30380413
Mol Ther. 2017 Oct 4;25(10):2323-2331
pubmed: 28750738
Elife. 2017 Sep 05;6:
pubmed: 28871961
Cell Host Microbe. 2018 May 9;23(5):672-685.e6
pubmed: 29746837
PLoS Negl Trop Dis. 2010 Mar 02;4(3):e617
pubmed: 20209155
Vaccines (Basel). 2020 Jan 22;8(1):
pubmed: 31979145
Adv Virus Res. 2003;60:421-67
pubmed: 14689700
mBio. 2013 Nov 19;4(6):e00873-13
pubmed: 24255124
Science. 2017 Nov 17;358(6365):929-932
pubmed: 29097492
J Infect Dis. 2017 Feb 1;215(3):351-358
pubmed: 27932620
J Virol. 2000 Apr;74(7):3227-34
pubmed: 10708439
Virology. 2008 Nov 10;381(1):67-74
pubmed: 18801552
J Virol. 2007 Dec;81(23):12766-74
pubmed: 17881450
J Virol. 2014 Oct;88(20):11726-37
pubmed: 25078693
J Virol. 2013 Aug;87(16):8826-42
pubmed: 23785205
Methods Mol Biol. 2014;1138:75-97
pubmed: 24696332
N Engl J Med. 2018 Jul 26;379(4):327-340
pubmed: 29897841
Virology. 2016 Oct;497:33-40
pubmed: 27420797
Biotechniques. 2000 Jun;28(6):1102, 1104
pubmed: 10868275
J Virol. 2006 Feb;80(3):1290-301
pubmed: 16415006
Lancet. 2020 May 2;395(10234):1434-1443
pubmed: 32197107
PLoS Negl Trop Dis. 2009;3(4):e423
pubmed: 19399166
PLoS Pathog. 2013 Mar;9(3):e1003265
pubmed: 23555265
Nat Rev Immunol. 2015 Dec;15(12):745-59
pubmed: 26603900
Sci Rep. 2016 Feb 29;6:22356
pubmed: 26924208
J Virol. 2010 Oct;84(20):10630-43
pubmed: 20702644
J Virol. 1999 Jan;73(1):783-6
pubmed: 9847388
Nat Microbiol. 2019 Sep;4(9):1508-1515
pubmed: 31182801
N Engl J Med. 2015 Sep 24;373(13):1195-206
pubmed: 26214039
PLoS Negl Trop Dis. 2016 Feb 05;10(2):e0004398
pubmed: 26848841
Yale J Biol Med. 1970 Apr;42(5):311-28
pubmed: 5419206
Ann Trop Med Parasitol. 1957 Dec;51(4):392-408
pubmed: 13498658
Virology. 1990 Feb;174(2):479-93
pubmed: 2129562
Science. 2015 Sep 18;349(6254):1338-43
pubmed: 26383952
Acta Crystallogr D Biol Crystallogr. 2009 May;65(Pt 5):510-2
pubmed: 19390156
Vaccines (Basel). 2020 Feb 02;8(1):
pubmed: 32024238
Am J Trop Med Hyg. 1952 Jan;1(1):30-50
pubmed: 14903434
Microbiol Mol Biol Rev. 2016 Oct 26;80(4):989-1010
pubmed: 27784796
Proc Natl Acad Sci U S A. 2018 Sep 4;115(36):E8378-E8387
pubmed: 30127007

Auteurs

Rita E Chen (RE)

Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110-1010, USA; Department of Pathology & Immunology, Washington University School of Medicine, St. Louis, MO 63110-1010, USA.

Brittany K Smith (BK)

Department of Pathology & Immunology, Washington University School of Medicine, St. Louis, MO 63110-1010, USA.

John M Errico (JM)

Department of Pathology & Immunology, Washington University School of Medicine, St. Louis, MO 63110-1010, USA.

David N Gordon (DN)

Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-9806, USA.

Emma S Winkler (ES)

Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110-1010, USA; Department of Pathology & Immunology, Washington University School of Medicine, St. Louis, MO 63110-1010, USA.

Laura A VanBlargan (LA)

Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110-1010, USA.

Chandni Desai (C)

Department of Pathology & Immunology, Washington University School of Medicine, St. Louis, MO 63110-1010, USA.

Scott A Handley (SA)

Department of Pathology & Immunology, Washington University School of Medicine, St. Louis, MO 63110-1010, USA.

Kimberly A Dowd (KA)

Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-9806, USA.

Emerito Amaro-Carambot (E)

Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-9806, USA.

M Jane Cardosa (MJ)

Institute of Health and Community Medicine, Universiti Sarawak Malaysia (UNIMAS), Kota Samarahan, Sarawak 94300, Malaysia; Integrated Research Associates, San Rafael, CA 94903, USA.

Carlos A Sariol (CA)

Unit of Comparative Medicine, Caribbean Primate Research Center, University of Puerto Rico-Medical Sciences Campus, San Juan, PR 00936-5067, USA.

Esper G Kallas (EG)

Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo 01246-903, Brazil.

Rafick-Pierre Sékaly (RP)

Department of Microbiology and Immunology, Department of Pathology, Emory University School of Medicine, Atlanta, GA 30322, USA.

Nikos Vasilakis (N)

Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, TX 77555, USA; Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555, USA; Sealy Center for Vector-Borne and Zoonotic Diseases, University of Texas Medical Branch, Galveston, TX 77555, USA.

Daved H Fremont (DH)

Department of Pathology & Immunology, Washington University School of Medicine, St. Louis, MO 63110-1010, USA; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110-1010, USA; Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, MO 63110-1010, USA; The Andrew M. Jane M. Bursky Center for Human Immunology & Immunotherapy Programs, Washington University School of Medicine, St. Louis, MO 63110-1010, USA.

Stephen S Whitehead (SS)

Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-9806, USA.

Theodore C Pierson (TC)

Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-9806, USA.

Michael S Diamond (MS)

Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110-1010, USA; Department of Pathology & Immunology, Washington University School of Medicine, St. Louis, MO 63110-1010, USA; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110-1010, USA; The Andrew M. Jane M. Bursky Center for Human Immunology & Immunotherapy Programs, Washington University School of Medicine, St. Louis, MO 63110-1010, USA; Center for Vaccines and Immunity to Microbial Pathogens, Washington University School of Medicine, Saint Louis, MO 63110-1010, USA. Electronic address: diamond@wusm.wustl.edu.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Implications of a highly divergent dengue...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Globulines › Sérum-globulines › Immunoglobulines › Anticorps › Anticorps antiviraux › Implications of a highly divergent dengue...
questionsmedicales.fr › Facteurs biologiques › Antigènes › Antigènes viraux › Implications of a highly divergent dengue...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Globulines › Sérum-globulines › Immunoglobulines › Anticorps › Anticorps neutralisants › Anticorps neutralisants à large spectre › Implications of a highly divergent dengue...
questionsmedicales.fr › Phénomènes du système immunitaire › Immunité › Protection croisée › Implications of a highly divergent dengue...
questionsmedicales.fr › Phénomènes du système immunitaire › Réaction antigène-anticorps › Réactions croisées › Implications of a highly divergent dengue...
questionsmedicales.fr › Infection › Maladies virales › Infections à virus à ARN › Fièvres hémorragiques virales › Dengue › Implications of a highly divergent dengue...
questionsmedicales.fr › Mélanges complexes › Produits biologiques › Vaccins › Vaccins antiviraux › Vaccins contre la dengue › Implications of a highly divergent dengue...
questionsmedicales.fr › Virus › Virus à ARN › Virus à ARN à brin positif › Flaviviridae › Flavivirus › Virus de la dengue › Implications of a highly divergent dengue...
questionsmedicales.fr › Phénomènes génétiques › Génotype › Implications of a highly divergent dengue...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Implications of a highly divergent dengue...
questionsmedicales.fr › Techniques d'investigation › Techniques immunologiques › Immunisation passive › Implications of a highly divergent dengue...
questionsmedicales.fr › Phénomènes du système immunitaire › Immunogénicité des vaccins › Implications of a highly divergent dengue...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Cercopithecidae › Cercopithecinae › Macaca › Macaca mulatta › Implications of a highly divergent dengue...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Implications of a highly divergent dengue...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Implications of a highly divergent dengue...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Implications of a highly divergent dengue...
questionsmedicales.fr › Phénomènes génétiques › Phénotype › Sérogroupe › Implications of a highly divergent dengue...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines virales › Protéines virales structurales › Protéines de l'enveloppe virale › Implications of a highly divergent dengue...