E. coli enhance colonization resistance against Salmonella Typhimurium by competing for galactitol, a context-dependent limiting carbon source.
Blautia coccoides
Enterocloster clostridioformis
Enterococcus faecalis
Freter
Oligo-MM
ecosystem invasion
niche pre-emption
nutrient-niche hypothesis
sDMDMm2
Journal
Cell host & microbe
ISSN: 1934-6069
Titre abrégé: Cell Host Microbe
Pays: United States
ID NLM: 101302316
Informations de publication
Date de publication:
10 11 2021
10 11 2021
Historique:
received:
29
03
2021
revised:
21
07
2021
accepted:
09
09
2021
pubmed:
6
10
2021
medline:
24
12
2021
entrez:
5
10
2021
Statut:
ppublish
Résumé
The composition of intrinsic microbial communities determines if invading pathogens will find a suitable niche for colonization and cause infection or be eliminated. Here, we investigate how commensal E. coli mediate colonization resistance (CR) against Salmonella Typhimurium (S. Tm). Using synthetic bacterial communities, we show that the capacity of E. coli Mt1B1 to block S. Tm colonization depends on the microbial context. In an infection-permissive context, E. coli utilized a high diversity of carbon sources and was unable to block S. Tm invasion. In mice that were stably colonized by twelve phylogenetically diverse murine gut bacteria (OMM
Identifiants
pubmed: 34610296
pii: S1931-3128(21)00420-0
doi: 10.1016/j.chom.2021.09.004
pii:
doi:
Substances chimiques
Galactitol
113ZQ1Y7DD
Carbon
7440-44-0
Types de publication
Journal Article
Comment
Langues
eng
Sous-ensembles de citation
IM
Pagination
1680-1692.e7Commentaires et corrections
Type : CommentOn
Type : CommentIn
Type : CommentIn
Informations de copyright
Copyright © 2021 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests The authors declare no competing interests.