Metabolic regulation of the cancer-immunity cycle.
CAR-T cells
PD-1
glycolysis
immunotherapy
lactate
metabolism
tumor immunology
Journal
Trends in immunology
ISSN: 1471-4981
Titre abrégé: Trends Immunol
Pays: England
ID NLM: 100966032
Informations de publication
Date de publication:
11 2021
11 2021
Historique:
received:
02
07
2021
revised:
09
09
2021
accepted:
11
09
2021
pubmed:
7
10
2021
medline:
8
4
2022
entrez:
6
10
2021
Statut:
ppublish
Résumé
The cancer-immunity cycle (CIC) comprises a series of events that are required for immune-mediated control of tumor growth. Interruption of one or more steps of the CIC enables tumors to evade immunosurveillance. However, attempts to restore antitumor immunity by reactivating the CIC have had limited success thus far. Recently, numerous studies have implicated metabolic reprogramming of tumor and immune cells within the tumor microenvironment (TME) as key contributors to immune evasion. In this opinion, we propose that alterations in cellular metabolism during tumorigenesis promote both initiation and disruption of the CIC. We also provide a rationale for metabolically targeting the TME, which may assist in improving tumor responsiveness to chimeric antigen receptor (CAR)-transduced T cells or immune checkpoint blockade (ICB) therapies.
Identifiants
pubmed: 34610889
pii: S1471-4906(21)00178-2
doi: 10.1016/j.it.2021.09.002
pmc: PMC8556351
mid: NIHMS1742614
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
975-993Subventions
Organisme : NCI NIH HHS
ID : K08 CA237731
Pays : United States
Informations de copyright
Copyright © 2021 Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests The authors have no interests to declare.
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