NEIL3-deficiency increases gut permeability and contributes to a pro-atherogenic metabolic phenotype.
Age Factors
Animals
Atherosclerosis
/ etiology
Biomarkers
Disease Models, Animal
Disease Susceptibility
Dysbiosis
Energy Metabolism
Gastrointestinal Microbiome
Genetic Predisposition to Disease
Humans
Immunohistochemistry
Intestinal Mucosa
/ metabolism
Mice
Mice, Knockout
N-Glycosyl Hydrolases
/ deficiency
Permeability
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
05 10 2021
05 10 2021
Historique:
received:
02
07
2021
accepted:
09
09
2021
entrez:
6
10
2021
pubmed:
7
10
2021
medline:
31
12
2021
Statut:
epublish
Résumé
Atherosclerosis and its consequences cause considerable morbidity and mortality world-wide. We have previously shown that expression of the DNA glycosylase NEIL3 is regulated in human atherosclerotic plaques, and that NEIL3-deficiency enhances atherogenesis in Apoe
Identifiants
pubmed: 34611194
doi: 10.1038/s41598-021-98820-0
pii: 10.1038/s41598-021-98820-0
pmc: PMC8492623
doi:
Substances chimiques
Biomarkers
0
N-Glycosyl Hydrolases
EC 3.2.2.-
NEIL3 protein, human
EC 3.2.2.-
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
19749Informations de copyright
© 2021. The Author(s).
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