Amiodarone attenuates cardiac Rubidium-82 in consecutive PET/CT scans in a rodent model.
Rats
Animals
Positron Emission Tomography Computed Tomography
Atorvastatin
/ pharmacology
Rodentia
Clopidogrel
Ticagrelor
Cross-Sectional Studies
Tomography, X-Ray Computed
Rats, Sprague-Dawley
Positron-Emission Tomography
/ methods
Coronary Artery Disease
/ diagnostic imaging
Rubidium Radioisotopes
Amlodipine
Myocardial Perfusion Imaging
CAD
MPI
PET
Physiology of myocardial/coronary perfusion
Journal
Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology
ISSN: 1532-6551
Titre abrégé: J Nucl Cardiol
Pays: United States
ID NLM: 9423534
Informations de publication
Date de publication:
12 2022
12 2022
Historique:
received:
30
05
2021
accepted:
23
07
2021
pubmed:
7
10
2021
medline:
14
1
2023
entrez:
6
10
2021
Statut:
ppublish
Résumé
Risk stratification and diagnosis using Rubidium-82 ( Seventy-seven Sprague-Dawley rats were included in the cross-sectional study. All rats underwent baseline In the control group without pharmacological treatment, no difference in the standard uptake value (SUV) ratio between heart and muscle from baseline to follow-up (5.8 vs 7.0, P = .3) was found. The group treated with amiodarone had a significantly reduced SUV ratio from baseline to follow-up (5.8 vs 5.1, P = .008). All other drugs investigated had no difference in SUV ratio from baseline to follow-up. In this study, we showed that drugs normally used to treat CAD do not affect the uptake of
Sections du résumé
BACKGROUND
Risk stratification and diagnosis using Rubidium-82 (
METHODS
Seventy-seven Sprague-Dawley rats were included in the cross-sectional study. All rats underwent baseline
RESULTS
In the control group without pharmacological treatment, no difference in the standard uptake value (SUV) ratio between heart and muscle from baseline to follow-up (5.8 vs 7.0, P = .3) was found. The group treated with amiodarone had a significantly reduced SUV ratio from baseline to follow-up (5.8 vs 5.1, P = .008). All other drugs investigated had no difference in SUV ratio from baseline to follow-up.
CONCLUSION
In this study, we showed that drugs normally used to treat CAD do not affect the uptake of
Identifiants
pubmed: 34611850
doi: 10.1007/s12350-021-02785-6
pii: 10.1007/s12350-021-02785-6
doi:
Substances chimiques
Rubidium-82
9K730EL8KU
Atorvastatin
A0JWA85V8F
Clopidogrel
A74586SNO7
Ticagrelor
GLH0314RVC
Rubidium Radioisotopes
0
Amlodipine
1J444QC288
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2853-2862Commentaires et corrections
Type : CommentIn
Informations de copyright
© 2021. American Society of Nuclear Cardiology.
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