Aging impairs human bone marrow function and cardiac repair following myocardial infarction in a humanized chimeric mouse.
Aged
Aging
/ metabolism
Animals
Antigens, CD34
/ metabolism
Bone Marrow Cells
/ metabolism
Bone Marrow Transplantation
/ methods
Cohort Studies
Coronary Vessels
/ metabolism
Disease Models, Animal
Female
Humans
Male
Mice
Mice, Inbred NOD
Mice, SCID
Middle Aged
Myocardial Infarction
/ metabolism
Neovascularization, Physiologic
Radiation Chimera
/ metabolism
Ventricular Remodeling
aging
bone marrow transplant
humanized mice
myocardial infarction
Journal
Aging cell
ISSN: 1474-9726
Titre abrégé: Aging Cell
Pays: England
ID NLM: 101130839
Informations de publication
Date de publication:
11 2021
11 2021
Historique:
revised:
15
08
2021
received:
26
01
2021
accepted:
26
09
2021
pubmed:
7
10
2021
medline:
26
2
2022
entrez:
6
10
2021
Statut:
ppublish
Résumé
Ventricular remodeling following myocardial infarction (MI) is a major cause of heart failure, a condition prevalent in older individuals. Following MI, immune cells are mobilized to the myocardium from peripheral lymphoid organs and play an active role in orchestrating repair. While the effect of aging on mouse bone marrow (BM) has been studied, less is known about how aging affects human BM cells and their ability to regulate repair processes. In this study, we investigate the effect aging has on human BM cell responses post-MI using a humanized chimeric mouse model. BM samples were collected from middle aged (mean age 56.4 ± 0.97) and old (mean age 72.7 ± 0.59) patients undergoing cardiac surgery, CD34
Identifiants
pubmed: 34612564
doi: 10.1111/acel.13494
pmc: PMC8590094
doi:
Substances chimiques
Antigens, CD34
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e13494Subventions
Organisme : CIHR
ID : 332652
Pays : Canada
Informations de copyright
© 2021 The Authors. Aging Cell published by Anatomical Society and John Wiley & Sons Ltd.
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