Mesenchymal Stromal Cells: an Antimicrobial and Host-Directed Therapy for Complex Infectious Diseases.
antimicrobial
cell therapy
clinical trials
host-directed therapy
immunomodulation
immunotherapy
infectious diseases
mesenchymal stromal cells
pathogens
Journal
Clinical microbiology reviews
ISSN: 1098-6618
Titre abrégé: Clin Microbiol Rev
Pays: United States
ID NLM: 8807282
Informations de publication
Date de publication:
15 12 2021
15 12 2021
Historique:
pubmed:
7
10
2021
medline:
3
2
2022
entrez:
6
10
2021
Statut:
ppublish
Résumé
There is an urgent need for new antimicrobial strategies for treating complex infections and emerging pathogens. Human mesenchymal stromal cells (MSCs) are adult multipotent cells with antimicrobial properties, mediated through direct bactericidal activity and modulation of host innate and adaptive immune cells. More than 30
Identifiants
pubmed: 34612662
doi: 10.1128/CMR.00064-21
pmc: PMC8510528
doi:
Substances chimiques
Anti-Bacterial Agents
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0006421Subventions
Organisme : Department of Health, Northern Ireland
Organisme : Medical Research Council
ID : MR/R025096/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/R017867/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/S009426/1
Pays : United Kingdom
Organisme : National Institute for Health Research (NIHR)
Organisme : Insmed
Organisme : Fundação Champalimaud (CF)
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : The Wellcome Trust
Organisme : European and Developing Countries Clinical Trials Partnership (EDCTP)
Organisme : Bill and Melinda Gates Foundation (BMGF)
Organisme : UKRI | Medical Research Council (MRC)