Fibrin gel enhances the antitumor effects of chimeric antigen receptor T cells in glioblastoma.
Journal
Science advances
ISSN: 2375-2548
Titre abrégé: Sci Adv
Pays: United States
ID NLM: 101653440
Informations de publication
Date de publication:
08 Oct 2021
08 Oct 2021
Historique:
entrez:
6
10
2021
pubmed:
7
10
2021
medline:
7
10
2021
Statut:
ppublish
Résumé
Regional delivery of chimeric antigen receptor (CAR) T cells in glioblastoma represents a rational therapeutic approach as an alternative to intravenous administration to avoid the blood-brain barrier impediment. Here, we developed a fibrin gel that accommodates CAR-T cell loading and promotes their gradual release. Using a model of subtotal glioblastoma resection, we demonstrated that the fibrin-based gel delivery of CAR-T cells within the surgical cavity enables superior antitumor activity compared to CAR-T cells directly inoculated into the tumor resection cavity.
Identifiants
pubmed: 34613775
doi: 10.1126/sciadv.abg5841
pmc: PMC8494441
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
eabg5841Subventions
Organisme : NCI NIH HHS
ID : T32 CA196589
Pays : United States
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