Iron: an underrated factor in aging.
aging
calorie restriction
iron
oxidative stress
plasma dilution
Journal
Aging
ISSN: 1945-4589
Titre abrégé: Aging (Albany NY)
Pays: United States
ID NLM: 101508617
Informations de publication
Date de publication:
06 10 2021
06 10 2021
Historique:
received:
12
09
2021
accepted:
27
09
2021
pubmed:
7
10
2021
medline:
9
2
2022
entrez:
6
10
2021
Statut:
ppublish
Résumé
Iron is an essential element for virtually all living organisms, but its reactivity also makes it potentially harmful. Iron accumulates with aging, and is associated with many age-related diseases; it also shortens the lifespans of several model organisms. Blocking iron absorption through drugs or natural products extends lifespan. Many life-extending interventions, such as rapamycin, calorie restriction, and old plasma dilution can be explained by the effects they have on iron absorption, excretion, and metabolism. Control of body iron stores so that they remain in a low normal range may be an important, lifespan- and healthspan-extending intervention.
Identifiants
pubmed: 34613935
pii: 203612
doi: 10.18632/aging.203612
pmc: PMC8544343
doi:
Substances chimiques
Iron
E1UOL152H7
TOR Serine-Threonine Kinases
EC 2.7.11.1
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
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