Platelet Heterogeneity in Myeloproliferative Neoplasms.
blood platelets
bone marrow
hemostasis
myelofibrosis
polycythemia vera
thrombosis
transcriptome
Journal
Arteriosclerosis, thrombosis, and vascular biology
ISSN: 1524-4636
Titre abrégé: Arterioscler Thromb Vasc Biol
Pays: United States
ID NLM: 9505803
Informations de publication
Date de publication:
11 2021
11 2021
Historique:
pubmed:
8
10
2021
medline:
23
11
2021
entrez:
7
10
2021
Statut:
ppublish
Résumé
Myeloproliferative neoplasms (MPNs) are a group of malignant disorders of the bone marrow where a dysregulated balance between proliferation and differentiation gives rise to abnormal numbers of mature blood cells. MPNs encompass a spectrum of disease entities with progressively more severe clinical features, including complications with thrombosis and hemostasis and an increased propensity for transformation to acute myeloid leukemia. There is an unmet clinical need for markers of disease progression. Our understanding of the precise mechanisms that influence pathogenesis and disease progression has been limited by access to disease-specific cells as biosources. Here, we review the landscape of MPN pathology and present blood platelets as potential candidates for disease-specific understanding. We conclude with our recent work discovering progressive platelet heterogeneity by subtype in a large clinical cohort of patients with MPN.
Identifiants
pubmed: 34615371
doi: 10.1161/ATVBAHA.121.316373
pmc: PMC8551046
mid: NIHMS1743022
doi:
Substances chimiques
Antineoplastic Agents
0
Platelet Aggregation Inhibitors
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
2661-2670Subventions
Organisme : NHGRI NIH HHS
ID : K08 HG010061
Pays : United States
Organisme : NIH HHS
ID : S10 OD025082
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR003142
Pays : United States
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