The effect of short term exposure to outdoor air pollution on fertility.
Abortion, Spontaneous
/ epidemiology
Adult
Air Pollutants
/ adverse effects
Air Pollution
/ adverse effects
Cohort Studies
Environmental Exposure
/ adverse effects
Female
Fertility
/ drug effects
Fertilization in Vitro
/ statistics & numerical data
Humans
Infant, Newborn
Infertility, Female
/ epidemiology
Male
Particulate Matter
/ adverse effects
Pregnancy
Pregnancy Outcome
/ epidemiology
Risk Factors
Spain
/ epidemiology
Time Factors
Treatment Outcome
Acute exposure
Fertility
Miscarriage
NO2
Nitrogen dioxide
PM10
PM2.5
Particulate matter
Pregnancy
Journal
Reproductive biology and endocrinology : RB&E
ISSN: 1477-7827
Titre abrégé: Reprod Biol Endocrinol
Pays: England
ID NLM: 101153627
Informations de publication
Date de publication:
06 Oct 2021
06 Oct 2021
Historique:
received:
12
07
2021
accepted:
24
09
2021
entrez:
7
10
2021
pubmed:
8
10
2021
medline:
4
2
2022
Statut:
epublish
Résumé
There is evidence to suggest that long term exposure to air pollution could be associated with decreased levels of fertility, although there is controversy as to how short term exposure may compromise fertility in IVF patients and what windows of exposure during the IVF process patients could be most vulnerable. This prospective cohort study aimed to evaluate the impact of acute exposure that air pollution have on reproductive outcomes in different moments of the IVF process. Women undergoing IVF living in Barcelona were recruited. Individual air pollution exposures were modelled at their home address 15 and 3 days before embryo transfer (15D and 3D, respectively), the same day of transfer (D0), and 7 days after (D7). The pollutants modelled were: PM One hundred ninety-four women were recruited, contributing with data for 486 embryo transfers. Acute and subacute exposure to PMs showed a tendency in increasing miscarriage rate and reducing clinical pregnancy rate, although results were not statistically significant. The first sensitivity analysis, showed a significant risk of miscarriage for PM Exposure to particulate matter has a negative impact on reproductive outcomes in IVF patients. Subacute exposure seems to increase the harmful effect of the acute exposure on miscarriage and pregnancy rates. Nitrogen dioxides do not modify significantly the reproductive success.
Sections du résumé
BACKGROUND
BACKGROUND
There is evidence to suggest that long term exposure to air pollution could be associated with decreased levels of fertility, although there is controversy as to how short term exposure may compromise fertility in IVF patients and what windows of exposure during the IVF process patients could be most vulnerable.
METHODS
METHODS
This prospective cohort study aimed to evaluate the impact of acute exposure that air pollution have on reproductive outcomes in different moments of the IVF process. Women undergoing IVF living in Barcelona were recruited. Individual air pollution exposures were modelled at their home address 15 and 3 days before embryo transfer (15D and 3D, respectively), the same day of transfer (D0), and 7 days after (D7). The pollutants modelled were: PM
RESULTS
RESULTS
One hundred ninety-four women were recruited, contributing with data for 486 embryo transfers. Acute and subacute exposure to PMs showed a tendency in increasing miscarriage rate and reducing clinical pregnancy rate, although results were not statistically significant. The first sensitivity analysis, showed a significant risk of miscarriage for PM
CONCLUSIONS
CONCLUSIONS
Exposure to particulate matter has a negative impact on reproductive outcomes in IVF patients. Subacute exposure seems to increase the harmful effect of the acute exposure on miscarriage and pregnancy rates. Nitrogen dioxides do not modify significantly the reproductive success.
Identifiants
pubmed: 34615529
doi: 10.1186/s12958-021-00838-6
pii: 10.1186/s12958-021-00838-6
pmc: PMC8493680
doi:
Substances chimiques
Air Pollutants
0
Particulate Matter
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
151Subventions
Organisme : instituto de salud carlos iii
ID : PI13/00454
Organisme : agència de gestió d'ajuts universitaris i de recerca
ID : SGB 2017-2019
Informations de copyright
© 2021. The Author(s).
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