Sex-Biased
Journal
Cancer discovery
ISSN: 2159-8290
Titre abrégé: Cancer Discov
Pays: United States
ID NLM: 101561693
Informations de publication
Date de publication:
02 2022
02 2022
Historique:
received:
16
10
2020
revised:
17
08
2021
accepted:
01
10
2021
pubmed:
8
10
2021
medline:
15
3
2022
entrez:
7
10
2021
Statut:
ppublish
Résumé
Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is an aggressive leukemia of plasmacytoid dendritic cells (pDC). BPDCN occurs at least three times more frequently in men than in women, but the reasons for this sex bias are unknown. Here, studying genomics of primary BPDCN and modeling disease-associated mutations, we link acquired alterations in RNA splicing to abnormal pDC development and inflammatory response through Toll-like receptors. Loss-of-function mutations in
Identifiants
pubmed: 34615655
pii: 2159-8290.CD-20-1513
doi: 10.1158/2159-8290.CD-20-1513
pmc: PMC8831459
mid: NIHMS1747625
doi:
Substances chimiques
Ribonucleoproteins
0
ZRSR2 protein, human
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
522-541Subventions
Organisme : NCI NIH HHS
ID : P30 CA008748
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA016672
Pays : United States
Organisme : NCI NIH HHS
ID : R35 CA231958
Pays : United States
Organisme : NCI NIH HHS
ID : R37 CA225191
Pays : United States
Informations de copyright
©2021 The Authors; Published by the American Association for Cancer Research.
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