Associations of
LRP5
MTHFR
genetic variant
osteoarthritis
osteoporosis
Journal
Therapeutics and clinical risk management
ISSN: 1176-6336
Titre abrégé: Ther Clin Risk Manag
Pays: New Zealand
ID NLM: 101253281
Informations de publication
Date de publication:
2021
2021
Historique:
received:
21
07
2021
accepted:
05
09
2021
entrez:
7
10
2021
pubmed:
8
10
2021
medline:
8
10
2021
Statut:
epublish
Résumé
Osteoarthritis (OA) is a common and degenerative joint disorder in the elderly. A greater importance of understanding the relationship between genetic factors and OA prevalence has emerged with population aging. We therefore investigated the associations of several bone disease-related genetic variants with the prevalence of OA and osteoporosis in Japanese elderly women from the Obuse study cohort, which was randomly sampled from a basic town resident registry. In total, 206 female participants (mean ± standard deviation age: 69.7 ± 11.0 years) who completed OA, bone mineral density, and genotype assessments were included. The number of patients diagnosed as having knee/hip OA and osteoporosis was 59 (28.6%) and 30 (14.6%), respectively. Fisher's exact testing revealed significant relationships between the minor T allele of In sum, the present study demonstrated significant associations of
Identifiants
pubmed: 34616152
doi: 10.2147/TCRM.S330530
pii: 330530
pmc: PMC8488030
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1065-1073Informations de copyright
© 2021 Nakano et al.
Déclaration de conflit d'intérêts
All of the authors have declared that there were no conflicts of interest in this study.
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