Current and Future Anti-VEGF Agents for Neovascular Age-Related Macular Degeneration.
KSI-301
aflibercept
anti-VEGF
bevacizumab
brolucizumab
ranibizumab
wet age-related macular degeneration
Journal
Journal of experimental pharmacology
ISSN: 1179-1454
Titre abrégé: J Exp Pharmacol
Pays: New Zealand
ID NLM: 101530345
Informations de publication
Date de publication:
2021
2021
Historique:
received:
26
06
2021
accepted:
06
09
2021
entrez:
7
10
2021
pubmed:
8
10
2021
medline:
8
10
2021
Statut:
epublish
Résumé
Age-related macular degeneration (AMD) is the most common cause of legal blindness in developed countries. Neovascular (ie, wet) AMD is currently managed with intravitreal therapy. Traditional treatments (ie, bevacizumab, ranibizumab, aflibercept) provide high-efficacy therapy but can also require frequent dosing. Newer and future anti-VEGF therapies aim to decrease injection frequency through eitherlonger half life or port-delivery systems (brolucizumab, conbercept, KSI-301, ranibizumab). This review outlines current anti-VEGF treatments and ways by which their duration might be extended.
Identifiants
pubmed: 34616189
doi: 10.2147/JEP.S259298
pii: 259298
pmc: PMC8488047
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
905-912Informations de copyright
© 2021 Kaiser et al.
Déclaration de conflit d'intérêts
Justis P Ehlers reports grants from Novartis, Alcon, Oxurion, Aerpio, Regeneron, Genentech, Boehringer-Ingelheim, and Roche, consulting fees from Novartis, Alcon, Adverum, Allergan, Thrombogenics, Aerpio, Stealth, Regeneron, Allegro, and Zeiss, and patents/intellectual property/licensing with Bioptigen/Leica outside the submitted work. The authors report no other conflicts of interest in this work.
Références
Ophthalmology. 2014 Jan;121(1):193-201
pubmed: 24084500
Ophthalmology. 2012 Jul;119(7):1388-98
pubmed: 22555112
Expert Opin Pharmacother. 2019 Oct;20(15):1879-1891
pubmed: 31298960
Ophthalmology. 2011 Oct;118(10):2041-9
pubmed: 21715011
Ophthalmology. 2020 Jul;127(7):963-976
pubmed: 32107066
Community Eye Health. 2014;27(87):49-50
pubmed: 25918464
Ophthalmology. 2019 Aug;126(8):1141-1154
pubmed: 30946888
Br J Ophthalmol. 2018 Apr;102(4):460-464
pubmed: 28779006
Ophthalmology. 2012 Dec;119(12):2537-48
pubmed: 23084240
J Cereb Blood Flow Metab. 2016 Feb;36(2):451-5
pubmed: 26661200
Ophthalmology. 2020 Oct;127(10):1345-1359
pubmed: 32344075
Ophthalmology. 2020 Oct;127(10):1331-1344
pubmed: 32471729
Expert Opin Investig Drugs. 2020 Jul;29(7):651-658
pubmed: 32479126
BMC Ophthalmol. 2020 May 25;20(1):206
pubmed: 32450838
Pharmaceutics. 2018 Jan 27;10(1):
pubmed: 29382038
Trials. 2020 Oct 20;21(1):866
pubmed: 33081849
Ophthalmology. 2013 Nov;120(11):2300-9
pubmed: 23916488
Clin Ophthalmol. 2016 Jan 13;10:87-96
pubmed: 26834453
Semin Ophthalmol. 2017;32(5):550-552
pubmed: 27191383
Nature. 2011 May 19;473(7347):298-307
pubmed: 21593862
Ophthalmology. 2007 May;114(5):855-9
pubmed: 17467524
Ophthalmol Retina. 2018 May;2(5):451-461
pubmed: 31047325
Ophthalmol Retina. 2018 May;2(5):475-480
pubmed: 31047329
Genes Cancer. 2011 Dec;2(12):1097-105
pubmed: 22866201
Br J Ophthalmol. 2015 Feb;99(2):220-6
pubmed: 25193672
Pharmaceutics. 2019 Jul 31;11(8):
pubmed: 31370346
N Engl J Med. 2006 Oct 5;355(14):1432-44
pubmed: 17021319
Eye (Lond). 2018 Feb;32(2):391-399
pubmed: 28937147
Invest Ophthalmol Vis Sci. 2008 May;49(5):1771-6
pubmed: 18436811
BMJ Open Ophthalmol. 2019 Dec 15;4(1):e000398
pubmed: 31909196
Am J Ophthalmol. 2019 Jan;197:156-167
pubmed: 30148987
Ophthalmology. 2020 Jan;127(1):72-84
pubmed: 30986442
Saudi Pharm J. 2017 Feb;25(2):165-175
pubmed: 28344466
Int J Retina Vitreous. 2020 May 22;6:18
pubmed: 32477592
Clin Ophthalmol. 2020 May 19;14:1349-1355
pubmed: 32546942
Bull World Health Organ. 2004 Nov;82(11):844-51
pubmed: 15640920
Ophthalmology. 2013 Apr;120(4):795-802
pubmed: 23260261
Cold Spring Harb Perspect Med. 2012 Jul;2(7):a006502
pubmed: 22762016
Ophthalmology. 2021 May 18;:
pubmed: 34019956
J Ocul Pharmacol Ther. 2017 Mar;33(2):115-122
pubmed: 28055308
Proc Natl Acad Sci U S A. 2002 Aug 20;99(17):11393-8
pubmed: 12177445
Lancet Glob Health. 2014 Feb;2(2):e106-16
pubmed: 25104651
Acta Ophthalmol Scand. 2000 Aug;78(4):448-50
pubmed: 10990049
Expert Opin Biol Ther. 2020 Sep;20(9):999-1008
pubmed: 32552072
N Engl J Med. 2011 May 19;364(20):1897-908
pubmed: 21526923
Exp Eye Res. 2015 Aug;137:111-24
pubmed: 25975234
Expert Opin Emerg Drugs. 2017 Sep;22(3):235-246
pubmed: 28756707
Drug Saf. 2015 Mar;38(3):279-93
pubmed: 25700714
Biomed Pharmacother. 2015 Apr;71:139-45
pubmed: 25960229
Expert Opin Pharmacother. 2005 Jul;6(8):1421-3
pubmed: 16013991
Retina. 2017 Oct;37(10):1847-1858
pubmed: 28106709
Drugs. 2019 Dec;79(18):1997-2000
pubmed: 31768932
Retina. 2020 Sep;40(9):1673-1685
pubmed: 31764612