A direct role of RNA polymerase III and RNA in DNA homologous recombination.
DNA double-strand breaks
RNA polymerase III
RNA–DNA hybrids
genetic deletion
homologous recombination
Journal
Molecular & cellular oncology
ISSN: 2372-3556
Titre abrégé: Mol Cell Oncol
Pays: United States
ID NLM: 101642411
Informations de publication
Date de publication:
2021
2021
Historique:
entrez:
7
10
2021
pubmed:
8
10
2021
medline:
8
10
2021
Statut:
epublish
Résumé
End resection excises several thousand bases from the 5'-ended strand during DNA double-strand break repair, creating 3'-end single-stranded DNA overhangs. This overhang requires strict protection from DNA2 or other nucleases digestion. A recent finding showed that the 3'-end overhangs are protected by the transient formation of RNA-DNA hybrids, and RNA polymerase III is an essential factor for homologous recombination.
Identifiants
pubmed: 34616870
doi: 10.1080/23723556.2021.1935173
pii: 1935173
pmc: PMC8489940
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1935173Informations de copyright
© 2021 Taylor & Francis Group, LLC.
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