Age Differences in Multimodal Quantitative Sensory Testing and Associations With Brain Volume.
Central nervous system
Cold detection threshold
Heat pain threshold
Mechanical threshold
Vibration detection threshold
Journal
Innovation in aging
ISSN: 2399-5300
Titre abrégé: Innov Aging
Pays: England
ID NLM: 101703706
Informations de publication
Date de publication:
2021
2021
Historique:
received:
05
05
2021
entrez:
7
10
2021
pubmed:
8
10
2021
medline:
8
10
2021
Statut:
epublish
Résumé
Somatosensory function is critical for successful aging. Prior studies have shown declines in somatosensory function with age; however, this may be affected by testing site, modality, and biobehavioral factors. While somatosensory function declines are associated with peripheral nervous system degradation, little is known regarding correlates with the central nervous system and brain structure in particular. The objectives of this study were to examine age-related declines in somatosensory function using innocuous and noxious stimuli, across 2 anatomical testing sites, with considerations for affect and cognitive function, and associations between somatosensory function and brain structure in older adults. A cross-sectional analysis included 84 "younger" ( Significant age × test site interaction effects were observed for warmth detection ( Our findings indicate healthy older adults display alterations in sensory responses to innocuous and noxious stimuli compared to younger adults and, furthermore, these alterations are uniquely affected by anatomical site. These findings suggest a nonuniform decline in somatosensation in older adults, which may represent peripheral and central nervous system alterations part of aging processes.
Sections du résumé
BACKGROUND AND OBJECTIVES
OBJECTIVE
Somatosensory function is critical for successful aging. Prior studies have shown declines in somatosensory function with age; however, this may be affected by testing site, modality, and biobehavioral factors. While somatosensory function declines are associated with peripheral nervous system degradation, little is known regarding correlates with the central nervous system and brain structure in particular. The objectives of this study were to examine age-related declines in somatosensory function using innocuous and noxious stimuli, across 2 anatomical testing sites, with considerations for affect and cognitive function, and associations between somatosensory function and brain structure in older adults.
RESEARCH DESIGN AND METHODS
METHODS
A cross-sectional analysis included 84 "younger" (
RESULTS
RESULTS
Significant age × test site interaction effects were observed for warmth detection (
DISCUSSION AND IMPLICATIONS
CONCLUSIONS
Our findings indicate healthy older adults display alterations in sensory responses to innocuous and noxious stimuli compared to younger adults and, furthermore, these alterations are uniquely affected by anatomical site. These findings suggest a nonuniform decline in somatosensation in older adults, which may represent peripheral and central nervous system alterations part of aging processes.
Identifiants
pubmed: 34616958
doi: 10.1093/geroni/igab033
pii: igab033
pmc: PMC8489433
doi:
Types de publication
Journal Article
Langues
eng
Pagination
igab033Subventions
Organisme : NIA NIH HHS
ID : T32 AG049673
Pays : United States
Informations de copyright
© The Author(s) 2021. Published by Oxford University Press on behalf of The Gerontological Society of America.
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