Toxoplasmosis in Treatment-Resistant Obsessive-Compulsive Disorder Patients.
Obsessive–compulsive disorder
Toxoplasma Gondii
Toxoplasmosis
Treatment resistance
Journal
Acta parasitologica
ISSN: 1896-1851
Titre abrégé: Acta Parasitol
Pays: Switzerland
ID NLM: 9301947
Informations de publication
Date de publication:
Mar 2022
Mar 2022
Historique:
received:
03
07
2021
accepted:
14
09
2021
pubmed:
8
10
2021
medline:
24
3
2022
entrez:
7
10
2021
Statut:
ppublish
Résumé
The current study was done to evaluate the relationship between T. gondii and obsessive-compulsive disorder (OCD) as well as prevalence rate of toxoplasmosis in treatment-resistant patients with OCD in comparison with treatment-sensitive patients with OCD. A total of 180 subjects were selected, including 90 patients with OCD and 90 control participants. Immunoglobulin G (IgG) and immunoglobulin M (IgM) antibodies against T. gondii were measured by the enzyme-linked immunosorbent assay (ELISA) technique. Detection of acute and chronic toxoplasmosis was carried out using the ELISA IgG avidity. In addition, the presence of this parasite in blood was detected using the nested-polymerase chain reaction (PCR) method. Regarding T. gondii IgG antibodies 42 (46.7%) and 17 (18.9%) cases were detected in the patients and controls, respectively (P = 0.000). Also, 16 (17.8%) and 5 (5.6%) cases were positive for B1 gene in patients and controls, respectively (P = 0.018). The antibodies were found to be related to risk of OCD [OR (95% CI) = 3.71 (1.88-7.30); P < 0.001]. Moreover, out of 90 patients, 35 and 55 cases were resistant and sensitive to treatment, respectively, so that 24 (68.6%) out of 35 and 18 (32.7%) out of 55 were positive for the antibodies (P = 0.01) as well as 11 (31.4%) out of 35 and 5 (9.1%) out of 55 were positive for B1 gene (P = 0.010). The antibodies were also associated with risk of resistance to treatment in patients with OCD [OR (95% CI) = 3.81 (1.42-10.17); P = 0.008]. Our findings showed that toxoplasmosis was more frequent in patients with OCD than the control group. In addition, prevalence rate of toxoplasmosis in treatment-resistant patients with OCD was significantly more than that in treatment-sensitive patients with OCD.
Sections du résumé
BACKGROUND AND OBJECTIVES
OBJECTIVE
The current study was done to evaluate the relationship between T. gondii and obsessive-compulsive disorder (OCD) as well as prevalence rate of toxoplasmosis in treatment-resistant patients with OCD in comparison with treatment-sensitive patients with OCD.
METHODS
METHODS
A total of 180 subjects were selected, including 90 patients with OCD and 90 control participants. Immunoglobulin G (IgG) and immunoglobulin M (IgM) antibodies against T. gondii were measured by the enzyme-linked immunosorbent assay (ELISA) technique. Detection of acute and chronic toxoplasmosis was carried out using the ELISA IgG avidity. In addition, the presence of this parasite in blood was detected using the nested-polymerase chain reaction (PCR) method.
RESULTS
RESULTS
Regarding T. gondii IgG antibodies 42 (46.7%) and 17 (18.9%) cases were detected in the patients and controls, respectively (P = 0.000). Also, 16 (17.8%) and 5 (5.6%) cases were positive for B1 gene in patients and controls, respectively (P = 0.018). The antibodies were found to be related to risk of OCD [OR (95% CI) = 3.71 (1.88-7.30); P < 0.001]. Moreover, out of 90 patients, 35 and 55 cases were resistant and sensitive to treatment, respectively, so that 24 (68.6%) out of 35 and 18 (32.7%) out of 55 were positive for the antibodies (P = 0.01) as well as 11 (31.4%) out of 35 and 5 (9.1%) out of 55 were positive for B1 gene (P = 0.010). The antibodies were also associated with risk of resistance to treatment in patients with OCD [OR (95% CI) = 3.81 (1.42-10.17); P = 0.008].
CONCLUSION
CONCLUSIONS
Our findings showed that toxoplasmosis was more frequent in patients with OCD than the control group. In addition, prevalence rate of toxoplasmosis in treatment-resistant patients with OCD was significantly more than that in treatment-sensitive patients with OCD.
Identifiants
pubmed: 34617192
doi: 10.1007/s11686-021-00471-8
pii: 10.1007/s11686-021-00471-8
doi:
Substances chimiques
Antibodies, Protozoan
0
Immunoglobulin M
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
356-361Subventions
Organisme : ahvaz jundishapur university of medical sciences
ID : IR.AJUMS.REC.1399.858
Informations de copyright
© 2021. Witold Stefański Institute of Parasitology, Polish Academy of Sciences.
Références
Chegeni TN, Sarvi S, Amouei A, Moosazadeh M, Hosseininejad Z, Aghayan SA et al (2019) Relationship between toxoplasmosis and obsessive compulsive disorder: a systematic review and meta-analysis. PLoS Neglected Tropical Dis 13(4):e0007306. https://doi.org/10.1371/journal.pntd.0007306
doi: 10.1371/journal.pntd.0007306
Alvarado-Esquivel C, Sanchez-Anguiano LF, Hernandez-Tinoco J, Berumen-Segovia LO, Torres-Prieto YE, Estrada-Martinez S, et al (2016). Toxoplasma gondii infection and mixed anxiety and depressive disorder: a case-control seroprevalence study in Durango, Mexico. J Clin Med Res 8(7):519. https://doi.org/10.14740/jocmr2576w .
de Barros JLVM, Barbosa IG, Salem H, Rocha NP, Kummer A, Okusaga OO et al (2017) Is there any association between Toxoplasma gondii infection and bipolar disorder? A systematic review and meta-analysis. J Affective Dis 209:59–65. https://doi.org/10.1016/j.jad.2016.11.016
doi: 10.1016/j.jad.2016.11.016
Cetinkaya Z, Yazar S, Gecici O, Namli MN (2007) Anti-Toxoplasma gondii antibodies in patients with schizophrenia—preliminary findings in a Turkish sample. Schizophrenia Bull 33(3):789–791. https://doi.org/10.1093/schbul/sbm021
doi: 10.1093/schbul/sbm021
Ene L, Marcotte T, Umlauf A, Grancea C, Temereanca A, Bharti A et al (2016) Latent toxoplasmosis is associated with neurocognitive impairment in young adults with and without chronic HIV infection. J Neuroimmunol 299:1–7. https://doi.org/10.1016/j.jneuroim.2016.08.003
doi: 10.1016/j.jneuroim.2016.08.003
pmcid: 5152755
Sutterland A, Fond G, Kuin A, Koeter M, Lutter R, Van Gool T et al (2015) Beyond the association. T oxoplasma gondii in schizophrenia, bipolar disorder, and addiction: systematic review and meta-analysis. Acta Psychiatr Scand 132(3):161–179. https://doi.org/10.1111/acps.12423
doi: 10.1111/acps.12423
Wang X, Zhang L, Lei Y, Liu X, Zhou X, Liu Y et al (2014) Meta-analysis of infectious agents and depression. Sci Rep 4:4530. https://doi.org/10.1038/srep04530
doi: 10.1038/srep04530
pmcid: 5380112
Ngoungou EB, Bhalla D, Nzoghe A, Dardé M-L, Preux P-M (2015) Toxoplasmosis and epilepsy—systematic review and meta analysis. PLoS Negl Trop Dis 9(2):e0003525. https://doi.org/10.1371/journal.pntd.0003525
doi: 10.1371/journal.pntd.0003525
pmcid: 4335039
Arias I, Sorlozano A, Villegas E, de Dios LJ, McKenney K, Cervilla J et al (2012) Infectious agents associated with schizophrenia: a meta-analysis. Schizophrenia Res 136(1–3):128–136. https://doi.org/10.1016/j.schres.2011.10.026
doi: 10.1016/j.schres.2011.10.026
Organization WH (1999). The “newly defined” burden of mental problems. Fact sheets. 217.
Flegr J, Horáček J (2017) Toxoplasma-infected subjects report an obsessive-compulsive disorder diagnosis more often and score higher in obsessive-compulsive inventory. Euro Psychiatry 40:82–87. https://doi.org/10.1016/j.eurpsy.2016.09.001
doi: 10.1016/j.eurpsy.2016.09.001
Miman O, Mutlu EA, Ozcan O, Atambay M, Karlidag R, Unal S (2010) Is there any role of Toxoplasma gondii in the etiology of obsessive–compulsive disorder? Psychiatry Res 177(1–2):263–265. https://doi.org/10.1016/j.psychres.2009.12.013
doi: 10.1016/j.psychres.2009.12.013
Memik NÇ, Tamer GS, Ünver H, Gündoğdu ÖY (2015) The relationship between pediatric obsessive compulsive disorder and Toxoplasma gondii. J Obsessive-Compulsive Related Dis 7:24–28. https://doi.org/10.1016/j.jocrd.2015.08.004
doi: 10.1016/j.jocrd.2015.08.004
Henriquez S, Brett R, Alexander J, Pratt J, Roberts C (2009) Neuropsychiatric disease and Toxoplasma gondii infection. NeuroImmunoModulation 16(2):122–133. https://doi.org/10.1159/000180267
doi: 10.1159/000180267
Westenberg HG, Fineberg NA, Denys D (2007) Neurobiology of obsessive-compulsive disorder: serotonin and beyond. CNS Spectr 12(S3):14–27. https://doi.org/10.1017/S1092852900002479
doi: 10.1017/S1092852900002479
Kar N, Misra B (2004) Toxoplasma seropositivity and depression: a case report. BMC Psychiatry 4(1):1–2. https://doi.org/10.1186/1471-244X-4-1
doi: 10.1186/1471-244X-4-1
pmcid: 356918
Smadja D, Cabre P, Prat C, Vernant J (1995) Loss of psychic auto-activation. Obsessive-compulsive behaviour. Toxoplasmic abscess of the basal ganglia. Revue neurologique. 151(4):271
Saki J, Mowla K, Arjmand R, Kazemi F, Fallahizadeh S (2019) Prevalence of Toxoplasma gondii and Toxocara canis among Myositis Patients in Southwest of Iran. Infect Disord Drug Targets. https://doi.org/10.2174/1871526520666191231123159
doi: 10.2174/1871526520666191231123159
Fallahi S, Kazemi B, Bandehpour M, Lasjerdi Z, Taghipour N, Zebardast N et al (2014) Comparison of the RE and B1 gene for detection of Toxoplasma gondii infection in children with cancer. Parasitol Int 63(1):37–41. https://doi.org/10.1016/j.parint.2013.08.005
doi: 10.1016/j.parint.2013.08.005
Arling TA, Yolken RH, Lapidus M, Langenberg P, Dickerson FB, Zimmerman SA et al (2009) Toxoplasma gondii antibody titers and history of suicide attempts in patients with recurrent mood disorders. J Nervous Mental Dis 197(12):905–908. https://doi.org/10.1097/NMD.0b013e3181c29a23
doi: 10.1097/NMD.0b013e3181c29a23
Akaltun İ, Kara SS, Kara T (2018) The relationship between Toxoplasma gondii IgG antibodies and generalized anxiety disorder and obsessive-compulsive disorder in children and adolescents: a new approach. Nordic J Psychiatry 72(1):57–62. https://doi.org/10.1080/08039488.2017.1385850
doi: 10.1080/08039488.2017.1385850
Brynska A, Tomaszewicz-Libudzic E, Wolanczyk T (2001) Obsessive-compulsive disorder and acquired toxoplasmosis in two children. Euro Child Adolescent Psychiatry. 10(3):200–204. https://doi.org/10.1007/s007870170027
doi: 10.1007/s007870170027
Miman Ö, Özcan Ö, Ünal S, Atambay M (2018) Toxoplasma gondii–obsessive–compulsive disorder elationship: is it different in children? Nordic J Psychiatry 72(7):501–505. https://doi.org/10.1080/08039488.2018.1514421
doi: 10.1080/08039488.2018.1514421
Flegr J (2013) How and why Toxoplasma makes us crazy. Trends Parasitol 29(4):156–163. https://doi.org/10.1016/j.pt.2013.01.007
doi: 10.1016/j.pt.2013.01.007
Webster JP, McConkey GA (2010). Toxoplasma gondii-altered host behaviour: clues as to mechanism of action. Folia Parasitologica. 57(2):95. https://doi.org/10.14411/fp.2010.012 .
Niebuhr DW, Millikan AM, Cowan DN, Yolken R, Li Y, Weber NS (2008) Selected infectious agents and risk of schizophrenia among US military personnel. Am J Psychiatry 165(1):99–106. https://doi.org/10.1176/appi.ajp.2007.06081254
doi: 10.1176/appi.ajp.2007.06081254
Havlíček J, Gašová Z, Smith AP, Zvára K, Flegr J (2001) Decrease of psychomotor performance in subjects with latent ‘asymptomatic’toxoplasmosis. Parasitology 122(5):515–520. https://doi.org/10.1017/s0031182001007624
doi: 10.1017/s0031182001007624
Abdoli A, Dalimi A, Arbabi M, Ghaffarifar F (2014). Neuropsychiatric manifestations of latent toxoplasmosis on mothers and their offspring. J Maternal-Fetal Neonatal Med 27(13):1368–74 https://doi.org/10.3109/14767058.2013.858685 .
Kessler M, Terramani T, Lynch G, Baudry M (1989) a glycine site associated with N-methyl-D-aspartic acid receptors: characterization and identification of a new class of antagonists. J Neurochem 52(4):1319–1328
doi: 10.1111/j.1471-4159.1989.tb01881.x
Alvarado-Esquivel C, Alanis-Quiñones O-P, Arreola-Valenzuela M-Á, Rodríguez-Briones A, Piedra-Nevarez L-J, Duran-Morales E, et al (2006). Seroepidemiology of Toxoplasma gondii infection in psychiatric inpatients in a northern Mexican city. BMC Infectious Dis. 6(1):1–7. org/ https://doi.org/10.1186/1471-2334-6-178 .