Effect of a Synthetic Organoselenium Compound on Post-Vaccination Immunopoiesis in the Red Bone Marrow and Cell Composition of Peripheral Blood of White Mice Vaccinated with Yersinia pestis EV.
Yersinia pestis EV
immunopoiesis
organoselenium
selenium
Journal
Bulletin of experimental biology and medicine
ISSN: 1573-8221
Titre abrégé: Bull Exp Biol Med
Pays: United States
ID NLM: 0372557
Informations de publication
Date de publication:
Sep 2021
Sep 2021
Historique:
received:
15
02
2021
pubmed:
8
10
2021
medline:
10
2
2022
entrez:
7
10
2021
Statut:
ppublish
Résumé
We studied the effect of an experimental synthetic organoselenium compound 2,6-dipyridinium- 9-selenabicyclo[3.3.1]nonane dibromide (974zh) on the cell composition of the red bone marrow and peripheral blood in white mice. The study drug co-administered with Yersinia pestis EV vaccine strain (103 CFU) potentiated maturation and migration of mature neutrophils from the bone marrow into the circulation. Reducing the dose of the live vaccine and the anti-inflammatory properties of the study drug made it possible to reduce the allergic reaction during the vaccination process.
Identifiants
pubmed: 34618261
doi: 10.1007/s10517-021-05287-0
pii: 10.1007/s10517-021-05287-0
doi:
Substances chimiques
Organoselenium Compounds
0
Vaccines, Attenuated
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
651-655Informations de copyright
© 2021. Springer Science+Business Media, LLC, part of Springer Nature.
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