SARS-CoV-2 infection generates tissue-localized immunological memory in humans.


Journal

Science immunology
ISSN: 2470-9468
Titre abrégé: Sci Immunol
Pays: United States
ID NLM: 101688624

Informations de publication

Date de publication:
19 Nov 2021
Historique:
pubmed: 8 10 2021
medline: 30 11 2021
entrez: 7 10 2021
Statut: ppublish

Résumé

Adaptive immune responses to SARS-CoV-2 infection have been extensively characterized in blood; however, most functions of protective immunity must be accomplished in tissues. Here, we report from examination of SARS-CoV-2 seropositive organ donors (ages 10 to 74) that CD4

Identifiants

pubmed: 34618554
doi: 10.1126/sciimmunol.abl9105
pmc: PMC8626868
mid: NIHMS1749294
doi:

Substances chimiques

Antibodies, Viral 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

eabl9105

Subventions

Organisme : NIAID NIH HHS
ID : U01 AI100119
Pays : United States
Organisme : NIAID NIH HHS
ID : P01 AI106697
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI100119
Pays : United States
Organisme : NIAID NIH HHS
ID : K23 AI141686
Pays : United States
Organisme : NIAID NIH HHS
ID : U19 AI142742
Pays : United States
Organisme : NIAID NIH HHS
ID : U19 AI128949
Pays : United States
Organisme : NCRR NIH HHS
ID : S10 RR027050
Pays : United States
Organisme : NHLBI NIH HHS
ID : U01 HL145547
Pays : United States
Organisme : NIH HHS
ID : S10 OD020056
Pays : United States

Références

Cell. 2021 Feb 18;184(4):861-880
pubmed: 33497610
Immunity. 2013 Jan 24;38(1):187-97
pubmed: 23260195
Nat Med. 2021 Apr;27(4):717-726
pubmed: 33664494
Immunity. 2018 Feb 20;48(2):202-213
pubmed: 29466753
J Exp Med. 2021 Apr 5;218(4):
pubmed: 33533915
J Leukoc Biol. 2014 Feb;95(2):215-24
pubmed: 24006506
J Immunol. 2011 Dec 1;187(11):5510-4
pubmed: 22058417
Proc Natl Acad Sci U S A. 2010 Jan 19;107(3):1172-7
pubmed: 20080619
Cell. 2021 Mar 18;184(6):1517-1529
pubmed: 33740452
Cell. 2020 Feb 20;180(4):749-763.e13
pubmed: 32059780
N Engl J Med. 2021 Jul 8;385(2):187-189
pubmed: 33951357
Nat Immunol. 2019 Jan;20(1):97-108
pubmed: 30510223
N Engl J Med. 2020 Oct 29;383(18):1724-1734
pubmed: 32871063
Nat Med. 2020 Jun;26(6):842-844
pubmed: 32398875
Cell. 2020 Jun 25;181(7):1489-1501.e15
pubmed: 32473127
Nature. 2021 May;593(7860):506-509
pubmed: 34035530
Sci Transl Med. 2021 Apr 21;13(590):
pubmed: 33723016
Pediatr Diabetes. 2014 Feb;15(1):1-9
pubmed: 24325575
Cell. 2020 Nov 12;183(4):996-1012.e19
pubmed: 33010815
Immunity. 2021 Apr 13;54(4):797-814.e6
pubmed: 33765436
Annu Rev Immunol. 2017 Apr 26;35:255-284
pubmed: 28142324
Cell Rep Med. 2021 Jul 20;2(7):100354
pubmed: 34250512
Annu Rev Immunol. 2011;29:621-63
pubmed: 21314428
Nat Rev Immunol. 2014 Jan;14(1):24-35
pubmed: 24336101
JCI Insight. 2018 Nov 15;3(22):
pubmed: 30429372
Nat Med. 2009 Mar;15(3):277-84
pubmed: 19234462
Sci Immunol. 2020 Jun 26;5(48):
pubmed: 32591408
Sci Immunol. 2021 Feb 23;6(56):
pubmed: 33622975
Immunol Rev. 2012 May;247(1):172-83
pubmed: 22500840
Cell. 2021 Jan 7;184(1):169-183.e17
pubmed: 33296701
Cell. 2020 Oct 1;183(1):143-157.e13
pubmed: 32877699
Nat Commun. 2019 Oct 17;10(1):4706
pubmed: 31624246
Immunity. 2016 Jun 21;44(6):1379-91
pubmed: 27287409
Cell Rep. 2021 Jun 22;35(12):109286
pubmed: 34161770
J Immunol. 2016 Aug 1;197(3):983-93
pubmed: 27342848
J Exp Med. 2021 Jan 4;218(1):
pubmed: 33005934
Nat Immunol. 2021 May;22(5):620-626
pubmed: 33674800
Curr Opin Virol. 2021 Feb;46:20-26
pubmed: 33130326
Annu Rev Immunol. 2012;30:429-57
pubmed: 22224772
Cell. 2014 Nov 6;159(4):814-28
pubmed: 25417158
N Engl J Med. 2021 May 13;384(19):1866-1868
pubmed: 33761203
PLoS One. 2017 Oct 24;12(10):e0186998
pubmed: 29065175
Annu Rev Immunol. 2019 Apr 26;37:521-546
pubmed: 30726153
Science. 2021 May 21;372(6544):815-821
pubmed: 33853970
Am J Transplant. 2018 Jan;18(1):74-88
pubmed: 28719147
Blood. 2020 Dec 10;136(24):2774-2785
pubmed: 32750113
J Immunol. 2018 Oct 1;201(7):2132-2140
pubmed: 30111633
PLoS Pathog. 2021 Jul 16;17(7):e1009761
pubmed: 34270631
J Immunol. 2016 Aug 1;197(3):994-1002
pubmed: 27335502
Nature. 2021 Mar;591(7851):639-644
pubmed: 33461210
Nat Med. 2021 Jul;27(7):1205-1211
pubmed: 34002089
Science. 2021 Feb 5;371(6529):
pubmed: 33408181
Sci Immunol. 2019 Apr 5;4(34):
pubmed: 30952804
Immunity. 2017 Mar 21;46(3):504-515
pubmed: 28329707
Immunity. 2019 May 21;50(5):1132-1148
pubmed: 31117010
Vaccine. 2021 Jul 22;39(32):4423-4428
pubmed: 34210573
Annu Rev Immunol. 2004;22:745-63
pubmed: 15032595
Nature. 2021 Jul;595(7867):426-431
pubmed: 34126625
Nature. 2021 Jul;595(7867):421-425
pubmed: 34030176
Nat Med. 2020 Apr;26(4):502-505
pubmed: 32284613
Cell. 2021 Apr 29;184(9):2332-2347.e16
pubmed: 33761326
Mucosal Immunol. 2019 Mar;12(2):378-389
pubmed: 30523311

Auteurs

Maya M L Poon (MML)

Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY 10032, USA.
Medical Scientist Training Program, Columbia University Irving Medical Center, New York, NY 10032, USA.

Ksenia Rybkina (K)

Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY 10032, USA.

Yu Kato (Y)

Center of Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA 92037, USA.

Masaru Kubota (M)

Department of Surgery, Columbia University Irving Medical Center, New York, NY 10032, USA.

Rei Matsumoto (R)

Department of Surgery, Columbia University Irving Medical Center, New York, NY 10032, USA.

Nathaniel I Bloom (NI)

Center of Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA 92037, USA.

Zeli Zhang (Z)

Center of Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA 92037, USA.

Kathryn M Hastie (KM)

Center of Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA 92037, USA.

Alba Grifoni (A)

Center of Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA 92037, USA.

Daniela Weiskopf (D)

Center of Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA 92037, USA.

Steven B Wells (SB)

Department of Systems Biology, Columbia University Irving Medical Center, New York, NY 10032, USA.

Basak B Ural (BB)

Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY 10032, USA.

Nora Lam (N)

Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY 10032, USA.
Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY 10032, USA.

Peter A Szabo (PA)

Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY 10032, USA.

Pranay Dogra (P)

Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY 10032, USA.

Yoon S Lee (YS)

Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY 10032, USA.

Joshua I Gray (JI)

Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY 10032, USA.

Marissa C Bradley (MC)

Department of Pediatrics, Columbia University Irving Medical Center, New York, NY 10032, USA.

Maigan A Brusko (MA)

Department of Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, FL 32611, USA.

Todd M Brusko (TM)

Department of Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, FL 32611, USA.

Erica O Saphire (EO)

Center of Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA 92037, USA.

Thomas J Connors (TJ)

Department of Pediatrics, Columbia University Irving Medical Center, New York, NY 10032, USA.

Alessandro Sette (A)

Center of Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA 92037, USA.
Division of Infectious Diseases and Global Public Health, Department of Medicine, University of California, San Diego, La Jolla, CA 92037, USA.

Shane Crotty (S)

Center of Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA 92037, USA.
Division of Infectious Diseases and Global Public Health, Department of Medicine, University of California, San Diego, La Jolla, CA 92037, USA.

Donna L Farber (DL)

Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY 10032, USA.
Department of Surgery, Columbia University Irving Medical Center, New York, NY 10032, USA.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female
Humans United States Aged Cross-Sectional Studies Medicare Part C
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH