Association of different fractionation schedules for prophylactic cranial irradiation with toxicity and brain metastases-free survival in stage III non-small cell lung cancer: A pooled analysis of individual patient data from three randomized trials.

Brain Neoplasms / radiotherapy Carcinoma, Non-Small-Cell Lung / radiotherapy Cranial Irradiation / adverse effects Humans Lung Neoplasms / radiotherapy Percutaneous Coronary Intervention Randomized Controlled Trials as Topic
Brain metastases-free survival Non-small cell lung cancer Prophylactic cranial irradiation Toxicity

Journal

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
ISSN: 1879-0887
Titre abrégé: Radiother Oncol
Pays: Ireland
ID NLM: 8407192

Informations de publication

Date de publication:
11 2021
Historique:
received: 22 07 2021
revised: 07 09 2021
accepted: 24 09 2021
pubmed: 8 10 2021
medline: 31 12 2021
entrez: 7 10 2021
Statut: ppublish

Résumé

We assessed the impact of different PCI fractionation schedules (30 Gy in 10 versus 15 fractions) on brain metastases-free survival (BMFS) and toxicity in stage III NSCLC. Our results suggest that 30 Gy in 10 fractions is associated with increased toxicity, while no conclusive evidence of improving BMFS was seen with this schedule.

Identifiants

DOI: 10.1016/j.radonc.2021.09.029 PMID: 34619235
pubmed: 34619235
pii: S0167-8140(21)08750-8
doi: 10.1016/j.radonc.2021.09.029
pii:
doi:

Types de publication

Journal Article Meta-Analysis Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

163-166

Informations de copyright

Copyright © 2021 The Author(s). Published by Elsevier B.V. All rights reserved.

Auteurs

Willem J A Witlox (WJA)

Department of Clinical Epidemiology and Medical Technology Assessment, Maastricht University Medical Centre (MUMC), The Netherlands; Department of Radiation Oncology (Maastro Clinic), Maastricht University Medical Centre (MUMC), The Netherlands. Electronic address: willem.witlox@mumc.nl.

Bram L T Ramaekers (BLT)

Department of Clinical Epidemiology and Medical Technology Assessment, Maastricht University Medical Centre (MUMC), The Netherlands.

Benjamin Lacas (B)

Department of Biostatistics and Epidemiology, Gustave Roussy, University Paris-Saclay, Villejuif, France; Oncostat U1018, Inserm, University Paris-Saclay, labeled Ligue Contre le Cancer, Villejuif, France.

Cecile Le Pechoux (CL)

Department of Radiation Oncology, Gustave Roussy, Paris-Saclay University, Villejuif, France.

Alexander Sun (A)

Princess Margaret Cancer Centre, Department of Radiation Oncology, University of Toronto, Canada.

Si-Yu Wang (SY)

Department of Thoracic Surgery, Sun Yat-sen University Cancer Center, Guangzhou, China.

Chen Hu (C)

NRG Oncology Statistics and Data Management Center, Philadelphia, United States; Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, United States.

Mary Redman (M)

Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, United States.

Vincent van der Noort (V)

Department of Biometrics, Netherlands Cancer Institute (NKI), Amsterdam, The Netherlands.

Ning Li (N)

Department of Experimental Research, Sun Yat-sen University Cancer Center, Guangzhou, China.

Matthias Guckenberger (M)

Department of Radiation Oncology, University Hospital Zurich, University of Zurich, Switzerland.

Harm van Tinteren (H)

Trial and Data Center, Princess Maxima Center for Pediatric Oncology, Utrecht, The Netherlands.

Harry J M Groen (HJM)

Department of Pulmonary Diseases, University of Groningen and University Medical Center Groningen, The Netherlands.

Manuela A Joore (MA)

Department of Clinical Epidemiology and Medical Technology Assessment, Maastricht University Medical Centre (MUMC), The Netherlands; Care and Public Health Research Institute (CAPHRI), Maastricht University, The Netherlands.

Dirk K M De Ruysscher (DKM)

Department of Radiation Oncology (Maastro Clinic), Maastricht University Medical Centre (MUMC), The Netherlands.

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Classifications MeSH

questionsmedicales.fr › Maladies du système nerveux › Tumeurs du système nerveux › Tumeurs du système nerveux central › Tumeurs du cerveau › Association of different fractionation...
questionsmedicales.fr › Maladies de l'appareil respiratoire › Tumeurs de l'appareil respiratoire › Tumeurs du poumon › Tumeurs des bronches › Carcinome bronchogénique › Carcinome pulmonaire non à petites cellules › Association of different fractionation...
questionsmedicales.fr › Thérapeutique › Radiothérapie › Irradiation crânienne › Association of different fractionation...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Association of different fractionation...
questionsmedicales.fr › Maladies de l'appareil respiratoire › Tumeurs de l'appareil respiratoire › Tumeurs du poumon › Association of different fractionation...
questionsmedicales.fr › Procédures de chirurgie opératoire › Interventions chirurgicales mini-invasives › Procédures endovasculaires › Intervention coronarienne percutanée › Association of different fractionation...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études cliniques comme sujet › Essais cliniques comme sujet › Essais cliniques contrôlés comme sujet › Essais contrôlés randomisés comme sujet › Association of different fractionation...