Antimicrobial resistance and virulence in Helicobacter pylori: Genomic insights.
Antimicrobial resistance
Gastric pathogen
Mobile genetic elements
Pathogenicity islands
Journal
Genomics
ISSN: 1089-8646
Titre abrégé: Genomics
Pays: United States
ID NLM: 8800135
Informations de publication
Date de publication:
11 2021
11 2021
Historique:
received:
14
05
2021
revised:
10
09
2021
accepted:
01
10
2021
pubmed:
8
10
2021
medline:
1
4
2022
entrez:
7
10
2021
Statut:
ppublish
Résumé
Microbes evolve rapidly by modifying their genome through mutations or acquisition of genetic elements. Antimicrobial resistance in Helicobacter pylori is increasingly prevalent in India. However, limited information is available about the genome of resistant H. pylori isolated from India. Our pan- and core-genome based analyses of 54 Indian H. pylori strains revealed plasticity of its genome. H. pylori is highly heterogenous both in terms of the genomic content and DNA sequence homology of ARGs and virulence factors. We observed that the H. pylori strains are clustered according to their geographical locations. The presence of point mutations in the ARGs and absence of acquired genetic elements linked with ARGs suggest target modifications are the primary mechanism of its antibiotic resistance. The findings of the present study would help in better understanding the emergence of drug-resistant H. pylori and controlling gastric disorders by advancing clinical guidance on selected treatment regimens.
Identifiants
pubmed: 34619341
pii: S0888-7543(21)00365-7
doi: 10.1016/j.ygeno.2021.10.002
pii:
doi:
Substances chimiques
Anti-Bacterial Agents
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
3951-3966Informations de copyright
Copyright © 2021. Published by Elsevier Inc.