Molecular docking analysis of DNA ligase from Staphylococcus aureus with identical polysaccharides.
DNA ligase
Molecular docking
Polysaccharide
S.aureus
Journal
Bioinformation
ISSN: 0973-2063
Titre abrégé: Bioinformation
Pays: Singapore
ID NLM: 101258255
Informations de publication
Date de publication:
2020
2020
Historique:
received:
31
07
2020
revised:
13
08
2020
accepted:
13
08
2020
entrez:
8
10
2021
pubmed:
9
10
2021
medline:
9
10
2021
Statut:
epublish
Résumé
Staphylococcus aureus has been recognized as an important human pathogen for more than 100 years. DNA ligase is the main protein responsible for the replication of S. aureus. DNA ligase was selected as successive target to control the replication mechanism. The antibacterial activity of polysaccharide is known. Therefore, it is of interest to study the activity of Polysaccharide analogues against DNA ligase in S. aureus using molecular docking analysis. We report ten analogues using scoring parameters with best two analogues as potential drug candidate for the combat of S. aureus infection.
Identifiants
pubmed: 34621118
doi: 10.6026/97320630016719
pii: 97320630016719
pmc: PMC8457022
doi:
Types de publication
Journal Article
Langues
eng
Pagination
719-724Informations de copyright
© 2020 Biomedical Informatics.
Déclaration de conflit d'intérêts
None declared.
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