Circulating Fibroblast Activation Protein as Potential Biomarker in Patients With Inflammatory Bowel Disease.
blood biomarkers
chronic patient
diagnosis
fibroblast activation protein
inflammatory bowel disease
mucosal healing
Journal
Frontiers in medicine
ISSN: 2296-858X
Titre abrégé: Front Med (Lausanne)
Pays: Switzerland
ID NLM: 101648047
Informations de publication
Date de publication:
2021
2021
Historique:
received:
15
06
2021
accepted:
20
08
2021
entrez:
8
10
2021
pubmed:
9
10
2021
medline:
9
10
2021
Statut:
epublish
Résumé
A major concern in the management of Inflammatory Bowel Disease (IBD) is the absence of accurate and specific biomarkers to drive diagnosis and monitor disease status timely and non-invasively. Fibroblast activation protein (FAP) represents a hallmark of IBD bowel strictures, being overexpressed in stenotic intestinal myofibroblasts. The present study aimed at evaluating the potential of circulating FAP (cFAP) as an accessible blood biomarker of IBD. Quantitative determination of cFAP was performed by enzyme-linked immunosorbent assay on plasma samples prospectively collected from patients with IBD and control subjects. A discrimination model was established on a training set of 50% patients and validated on independent samples. Results showed that cFAP concentration was reduced in patients with IBD when compared to controls (
Identifiants
pubmed: 34621763
doi: 10.3389/fmed.2021.725726
pmc: PMC8490650
doi:
Types de publication
Journal Article
Langues
eng
Pagination
725726Informations de copyright
Copyright © 2021 Corsi, Sorrentino, Albasini, Colombo, Cigognini, Massari, Morasso, Mazzucchelli, Piccotti, Ardizzone, Sampietro and Truffi.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Gastroenterology. 2015 Oct;149(5):1275-1285.e2
pubmed: 26166315
Nanotechnology. 2021 Apr 30;32(29):
pubmed: 33831854
Int J Cardiol. 2017 Apr 1;232:155-159
pubmed: 28082091
J Crohns Colitis. 2016 Aug;10(8):873-85
pubmed: 26928961
J Clin Invest. 2003 Jun;111(12):1805-12
pubmed: 12813013
Can J Gastroenterol. 2011 May;25(5):269-73
pubmed: 21647462
Aliment Pharmacol Ther. 2003 Oct 1;18(7):749-56
pubmed: 14510749
Drugs. 2017 Feb;77(2):159-173
pubmed: 28078646
Int Rev Cell Mol Biol. 2012;297:83-116
pubmed: 22608558
Korean J Radiol. 2016 May-Jun;17(3):339-50
pubmed: 27134523
Gut. 2006 Jun;55(6):749-53
pubmed: 16698746
Clin Transl Med. 2015 Feb 07;4:1
pubmed: 25852817
Inflamm Bowel Dis. 2011 May;17(5):1251-3
pubmed: 20806341
JCI Insight. 2020 Aug 20;5(16):
pubmed: 32663193
Dig Dis. 2017;35(1-2):32-37
pubmed: 28147365
Am J Gastroenterol. 2012 Nov;107(11):1760-1
pubmed: 23160303
Clin Gastroenterol Hepatol. 2018 May;16(5):621-623
pubmed: 29454042
Am J Gastroenterol. 2006 Mar;101(3):413-6
pubmed: 16542272
Am J Gastroenterol. 2006 Oct;101(10):2410-22
pubmed: 16952282
World J Gastrointest Pharmacol Ther. 2016 Feb 6;7(1):41-50
pubmed: 26855811
Therap Adv Gastroenterol. 2019 Jun 14;12:1756284819856865
pubmed: 31236140
J Crohns Colitis. 2017 Jan;11(1):3-25
pubmed: 27660341
J Crohns Colitis. 2017 Feb;11(2):135-149
pubmed: 27660342
Abdom Imaging. 2012 Jun;37(3):387-96
pubmed: 21879316
Int J Rheum Dis. 2018 Nov;21(11):1915-1923
pubmed: 27990763
World J Gastroenterol. 2021 Apr 28;27(16):1828-1840
pubmed: 33967560
Gastroenterology. 1991 Sep;101(3):618-25
pubmed: 1677636
Am J Gastroenterol. 2007 Apr;102(4):803-13
pubmed: 17324124
Oncotarget. 2017 May 2;8(18):30050-30062
pubmed: 28415791
J Crohns Colitis. 2015 Jan;9(1):26-32
pubmed: 25008478
Blood. 2006 Feb 15;107(4):1397-404
pubmed: 16223769
Adv Clin Chem. 2018;87:161-190
pubmed: 30342711
Int J Biochem Cell Biol. 2004 Nov;36(11):2320-33
pubmed: 15313476
Dis Markers. 2012;32(5):309-20
pubmed: 22674411
Gastroenterology. 2020 Feb;158(3):515-526.e10
pubmed: 31711925
J Biol Chem. 1992 Mar 5;267(7):4824-33
pubmed: 1347043
Scand J Gastroenterol. 2013 Sep;48(9):1048-54
pubmed: 23883068
World J Gastroenterol. 2018 Sep 7;24(33):3681-3694
pubmed: 30197475
Inflamm Bowel Dis. 2018 Jan 18;24(2):332-345
pubmed: 29361086