Genome-wide homozygosity and risk of four non-Hodgkin lymphoma subtypes.

Non-Hodgkin lymphoma chronic lymphocytic leukemia diffuse large B-cell lymphoma follicular lymphoma homozygosity marginal zone lymphoma

Journal

Journal of translational genetics and genomics
ISSN: 2578-5281
Titre abrégé: J Transl Genet Genom
Pays: United States
ID NLM: 101754424

Informations de publication

Date de publication:
2021
Historique:
entrez: 8 10 2021
pubmed: 9 10 2021
medline: 9 10 2021
Statut: ppublish

Résumé

Recessive genetic variation is thought to play a role in non-Hodgkin lymphoma (NHL) etiology. Runs of homozygosity (ROH), defined based on long, continuous segments of homozygous SNPs, can be used to estimate both measured and unmeasured recessive genetic variation. We sought to examine genome-wide homozygosity and NHL risk. We used data from eight genome-wide association studies of four common NHL subtypes: 3061 chronic lymphocytic leukemia (CLL), 3814 diffuse large B-cell lymphoma (DLBCL), 2784 follicular lymphoma (FL), and 808 marginal zone lymphoma (MZL) cases, as well as 9374 controls. We examined the effect of homozygous variation on risk by: (1) estimating the fraction of the autosome containing runs of homozygosity (FROH); (2) calculating an inbreeding coefficient derived from the correlation among uniting gametes (F3); and (3) examining specific autosomal regions containing ROH. For each, we calculated beta coefficients and standard errors using logistic regression and combined estimates across studies using random-effects meta-analysis. We discovered positive associations between FROH and CLL (β = 21.1, SE = 4.41, Our findings support the role of recessive genetic variation in the etiology of CLL and FL; additional research is needed to identify the specific loci associated with NHL risk.

Identifiants

pubmed: 34622145
doi: 10.20517/jtgg.2021.08
pmc: PMC8494431
mid: NIHMS1720209
doi:

Types de publication

Journal Article

Langues

eng

Pagination

200-217

Subventions

Organisme : NHLBI NIH HHS
ID : HHSN268201100046C
Pays : United States
Organisme : NIEHS NIH HHS
ID : P30 ES000260
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA008748
Pays : United States
Organisme : NCI NIH HHS
ID : HHSN261201000034C
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA134674
Pays : United States
Organisme : NCI NIH HHS
ID : N01 PC067009
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201100001I
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA016087
Pays : United States
Organisme : NCI NIH HHS
ID : HHSN261201000140C
Pays : United States
Organisme : NCI NIH HHS
ID : N01 PC067010
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA098122
Pays : United States
Organisme : NHGRI NIH HHS
ID : U01 HG007033
Pays : United States
Organisme : NCI NIH HHS
ID : P01 CA087969
Pays : United States
Organisme : NCI NIH HHS
ID : HHSN261201000035C
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA134958
Pays : United States
Organisme : NCI NIH HHS
ID : R21 CA165923
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201100004I
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA086862
Pays : United States
Organisme : NCI NIH HHS
ID : U01 CA167552
Pays : United States
Organisme : NCI NIH HHS
ID : N01 PC067008
Pays : United States
Organisme : WHI NIH HHS
ID : HHSN268201100003C
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA148690
Pays : United States
Organisme : Blood Cancer UK
ID : 22015
Pays : United Kingdom
Organisme : NCCDPHP CDC HHS
ID : U58 DP000807
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA154643
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA062006
Pays : United States
Organisme : NCI NIH HHS
ID : N01 PC065064
Pays : United States
Organisme : NCI NIH HHS
ID : K08 CA134919
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR000135
Pays : United States
Organisme : NIA NIH HHS
ID : HHSN271201100004C
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA098661
Pays : United States
Organisme : NCI NIH HHS
ID : UM1 CA186107
Pays : United States
Organisme : WHI NIH HHS
ID : HHSN268201100002C
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA015083
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA092153
Pays : United States
Organisme : Intramural NIH HHS
ID : ZIA CP010136
Pays : United States
Organisme : NCI NIH HHS
ID : HHSN261201000035I
Pays : United States
Organisme : NCI NIH HHS
ID : P50 CA097274
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201100003I
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA049449
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201100002I
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA200703
Pays : United States
Organisme : NCI NIH HHS
ID : N01CO12400
Pays : United States
Organisme : CCR NIH HHS
ID : HHSN261200800001C
Pays : United States
Organisme : NCI NIH HHS
ID : U01 CA049449
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA149445
Pays : United States
Organisme : NCI NIH HHS
ID : HHSN261201000026C
Pays : United States
Organisme : WHI NIH HHS
ID : HHSN268201100001C
Pays : United States
Organisme : WHI NIH HHS
ID : HHSN268201100004C
Pays : United States
Organisme : NCI NIH HHS
ID : U01 CA118444
Pays : United States
Organisme : NCI NIH HHS
ID : HHSN261200800001E
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA042014
Pays : United States

Déclaration de conflit d'intérêts

Conflicts of interest All authors declare that there are no conflicts of interest.

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Auteurs

Amy Moore (A)

Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA.

Mitchell J Machiela (MJ)

Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA.

Moara Machado (M)

Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA.
Departamento de Biologia Geral, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte 31270-901, Brazil.

Sophia S Wang (SS)

Division of Health Analytics, City of Hope Beckman Research Institute, Duarte, CA 91010, USA.

Eleanor Kane (E)

Department of Health Sciences, University of York, York YO10 5DD, UK.

Susan L Slager (SL)

Department of Health Sciences Research, Mayo Clinic, Rochester, MN 55905, USA.

Weiyin Zhou (W)

Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA.
Cancer Genomics Research Laboratory, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Gaithersburg, MD 20877, USA.

Mary Carrington (M)

Basic Science Program, Frederick National Laboratory for Cancer Research in the Laboratory of Integrative Cancer Immunology, National Cancer Institute, Bethesda, MD 20892, USA.
Ragon Institute of MGH, Cambridge, MA 02139, USA.

Qing Lan (Q)

Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA.

Roger L Milne (RL)

Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, Victoria 3004, Australia.
Centre for Epidemiology and Biostatistics, School of Population and Global Health, The University of Melbourne, Melbourne, Victoria 3010, Australia.
Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, Victoria 3800, Australia.

Brenda M Birmann (BM)

Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.

Hans-Olov Adami (HO)

Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 17176, Sweden.
Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.
Institute of Health and Society, Clinical Effectiveness Research Group, University of Oslo, Oslo 0315, Norway.

Demetrius Albanes (D)

Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA.

Alan A Arslan (AA)

Department of Obstetrics and Gynecology, New York University School of Medicine, New York, NY 10016, USA.
Department of Population Health, New York University School of Medicine, New York, NY 10016, USA.
Perlmutter Comprehensive Cancer Center, NYU Langone Health, New York, NY 10016, USA.

Nikolaus Becker (N)

Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Baden-Württemberg 69120, Germany.

Yolanda Benavente (Y)

Cancer Epidemiology Research Programme, Catalan Institute of Oncology-IDIBELL, L'Hospitalet de Llobregat, Barcelona 08908, Spain.
Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Barcelona 08036, Spain.

Simonetta Bisanzi (S)

Regional Cancer Prevention Laboratory, Institute for Cancer Research, Prevention and Clinical Network (ISPRO), Florence 50139, Italy.

Paolo Boffetta (P)

Stony Brook Cancer Center, Stony Brook University, Stony Brook, NY 11794, USA.
Department of Medical and Surgical Sciences, University of Bologna, Bologna 41026, Italy.

Paige M Bracci (PM)

Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA 94118, USA.

Paul Brennan (P)

International Agency for Research on Cancer (IARC), Lyon 69372, France.

Angela R Brooks-Wilson (AR)

Genome Sciences Centre, BC Cancer Agency, Vancouver, British Columbia V5Z1L3, Canada.
Department of Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, British Columbia V5A1S6, Canada.

Federico Canzian (F)

Genomic Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg 69120, Germany.

Neil Caporaso (N)

Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA.

Jacqueline Clavel (J)

Center of Research in Epidemiology and Statistics Sorbonne Paris Cité (CRESS), UMR1153, INSERM, Villejuif 75004, France.

Pierluigi Cocco (P)

Department of Public Health, Clinical and Molecular Medicine, University of Cagliari, Monserrato, Cagliari 09042, Italy.

Lucia Conde (L)

Bill Lyons Informatics Centre, UCL Cancer Institute, University College London, London WC1E 6DD, UK.

David G Cox (DG)

INSERM U1052, Cancer Research Center of Lyon, Centre Léon Bérard, Lyon 69008, France.

Wendy Cozen (W)

Department of Preventive Medicine, USC Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
Norris Comprehensive Cancer Center, USC Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.

Karen Curtin (K)

Department of Internal Medicine and Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT 84112, USA.

Immaculata De Vivo (I)

Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.

Silvia de Sanjose (S)

Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA.
Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Barcelona 08036, Spain.

Lenka Foretova (L)

Department of Cancer Epidemiology and Genetics, Masaryk Memorial Cancer Institute, Brno 656 53, Czech Republic.

Susan M Gapstur (SM)

Department of Population Science, American Cancer Society, Atlanta, GA 30303, USA.

Hervè Ghesquières (H)

Department of Hematology, Centre Léon Bérard, Lyon 69008, France.
INSERM U1052, Cancer Research Center of Lyon, Lyon-1 University, Pierre-Bénite Cedex 69008, France.

Graham G Giles (GG)

Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, Victoria 3004, Australia.
Centre for Epidemiology and Biostatistics, School of Population and Global Health, The University of Melbourne, Melbourne, Victoria 3010, Australia.
Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, Victoria 3800, Australia.

Martha Glenn (M)

Department of Internal Medicine and Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT 84112, USA.

Bengt Glimelius (B)

Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala 75105, Sweden.

Chi Gao (C)

Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.

Thomas M Habermann (TM)

Department of Internal Medicine, Mayo Clinic, Rochester, MN 55905, USA.

Henrik Hjalgrim (H)

Department of Epidemiology Research, Division of Health Surveillance and Research, Statens Serum Institut, Copenhagen 2300, Denmark.

Rebecca D Jackson (RD)

Division of Endocrinology, Diabetes and Metabolism, The Ohio State University, Columbus, OH 43210, USA.

Mark Liebow (M)

Department of Internal Medicine, Mayo Clinic, Rochester, MN 55905, USA.

Brian K Link (BK)

Department of Internal Medicine, Carver College of Medicine, The University of Iowa, Iowa City, IA 52242, USA.

Marc Maynadie (M)

U1231, Registre des Hémopathies Malignes de Côte d'Or, University of Burgundy and Dijon University Hospital, Dijon 21070, France.

James McKay (J)

International Agency for Research on Cancer (IARC), Lyon 69372, France.

Mads Melbye (M)

Department of Epidemiology Research, Division of Health Surveillance and Research, Statens Serum Institut, Copenhagen 2300, Denmark.
Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.

Lucia Miligi (L)

Environmental and Occupational Epidemiology Branch-Cancer Risk Factors and Lifestyle Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network (ISPRO), Florence 50139, Italy.

Thierry J Molina (TJ)

Department of Pathology, AP-HP, Necker Enfants Malades, Université Paris Descartes, EA 7324, Sorbonne Paris Cité 75015, France.

Alain Monnereau (A)

Center of Research in Epidemiology and Statistics Sorbonne Paris Cité (CRESS), UMR1153, INSERM, Villejuif 75004, France.
Registre des Hémopathies Malignes de la Gironde, Institut Bergonié, Bordeaux Cedex 33076, France.

Alexandra Nieters (A)

Center for Chronic Immunodeficiency, University Medical Center Freiburg, Freiburg, Baden-Württemberg 79108, Germany.

Kari E North (KE)

Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Carolina Center for Genome Sciences, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

Kenneth Offit (K)

Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

Alpa V Patel (AV)

Department of Population Science, American Cancer Society, Atlanta, GA 30303, USA.

Sara Piro (S)

Environmental and Occupational Epidemiology Branch-Cancer Risk Factors and Lifestyle Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network (ISPRO), Florence 50139, Italy.

Vignesh Ravichandran (V)

Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

Elio Riboli (E)

School of Public Health, Imperial College London, London W2 1PG, UK.

Gilles Salles (G)

INSERM U1052, Cancer Research Center of Lyon, Lyon-1 University, Pierre-Bénite Cedex 69008, France.
Department of Hematology, Hospices Civils de Lyon, Pierre Benite Cedex 69495, France.
Department of Hematology, Université Lyon-1, Pierre Benite Cedex 69495, France.

Richard K Severson (RK)

Department of Family Medicine and Public Health Sciences, Wayne State University, Detroit, MI 48201, USA.

Christine F Skibola (CF)

Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, GA 30322, USA.

Karin E Smedby (KE)

Department of Medicine, Solna, Karolinska Institutet, Stockholm 17176, Sweden.
Hematology Center, Karolinska University Hospital, Stockholm 17176, Sweden.

Melissa C Southey (MC)

Genetic Epidemiology Laboratory, Department of Pathology, University of Melbourne, Melbourne, Victoria 3010, Australia.

John J Spinelli (JJ)

Cancer Control Research, BC Cancer Agency, Vancouver, British Columbia V5Z1L3, Canada.
School of Population and Public Health, University of British Columbia, Vancouver, British Columbia V6T1Z3, Canada.

Anthony Staines (A)

School of Nursing, Psychotherapy and Community Health, Dublin City University, Dublin 9, Ireland.

Carolyn Stewart (C)

Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

Lauren R Teras (LR)

Department of Population Science, American Cancer Society, Atlanta, GA 30303, USA.

Lesley F Tinker (LF)

Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98117, USA.

Ruth C Travis (RC)

Cancer Epidemiology Unit, University of Oxford, Oxford OX3 7LF, UK.

Claire M Vajdic (CM)

Centre for Big Data Research in Health, University of New South Wales, Sydney, New South Wales 2052, Australia.

Roel C H Vermeulen (RCH)

Institute for Risk Assessment Sciences, Utrecht University, Utrecht 3584 CG, The Netherlands.
Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht 3584 CX, The Netherlands.

Joseph Vijai (J)

Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

Elisabete Weiderpass (E)

International Agency for Research on Cancer (IARC), Lyon 69372, France.

Stephanie Weinstein (S)

Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA.

Nicole Wong Doo (NW)

Concord Clinical School, University of Sydney, Concord, New South Wales 2139, Australia.

Yawei Zhang (Y)

Department of Environmental Health Sciences, Yale School of Public Health, New Haven, CT 06520, USA.

Tongzhang Zheng (T)

Department of Epidemiology, Brown University, Providence, RI 02903, USA.

Stephen J Chanock (SJ)

Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA.

Nathaniel Rothman (N)

Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA.

James R Cerhan (JR)

Department of Health Sciences Research, Mayo Clinic, Rochester, MN 55905, USA.

Michael Dean (M)

Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA.

Nicola J Camp (NJ)

Department of Internal Medicine and Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT 84112, USA.

Meredith Yeager (M)

Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA.
Cancer Genomics Research Laboratory, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Gaithersburg, MD 20877, USA.

Sonja I Berndt (SI)

Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA.

Classifications MeSH