Genome-wide homozygosity and risk of four non-Hodgkin lymphoma subtypes.
Non-Hodgkin lymphoma
chronic lymphocytic leukemia
diffuse large B-cell lymphoma
follicular lymphoma
homozygosity
marginal zone lymphoma
Journal
Journal of translational genetics and genomics
ISSN: 2578-5281
Titre abrégé: J Transl Genet Genom
Pays: United States
ID NLM: 101754424
Informations de publication
Date de publication:
2021
2021
Historique:
entrez:
8
10
2021
pubmed:
9
10
2021
medline:
9
10
2021
Statut:
ppublish
Résumé
Recessive genetic variation is thought to play a role in non-Hodgkin lymphoma (NHL) etiology. Runs of homozygosity (ROH), defined based on long, continuous segments of homozygous SNPs, can be used to estimate both measured and unmeasured recessive genetic variation. We sought to examine genome-wide homozygosity and NHL risk. We used data from eight genome-wide association studies of four common NHL subtypes: 3061 chronic lymphocytic leukemia (CLL), 3814 diffuse large B-cell lymphoma (DLBCL), 2784 follicular lymphoma (FL), and 808 marginal zone lymphoma (MZL) cases, as well as 9374 controls. We examined the effect of homozygous variation on risk by: (1) estimating the fraction of the autosome containing runs of homozygosity (FROH); (2) calculating an inbreeding coefficient derived from the correlation among uniting gametes (F3); and (3) examining specific autosomal regions containing ROH. For each, we calculated beta coefficients and standard errors using logistic regression and combined estimates across studies using random-effects meta-analysis. We discovered positive associations between FROH and CLL (β = 21.1, SE = 4.41, Our findings support the role of recessive genetic variation in the etiology of CLL and FL; additional research is needed to identify the specific loci associated with NHL risk.
Identifiants
pubmed: 34622145
doi: 10.20517/jtgg.2021.08
pmc: PMC8494431
mid: NIHMS1720209
doi:
Types de publication
Journal Article
Langues
eng
Pagination
200-217Subventions
Organisme : NHLBI NIH HHS
ID : HHSN268201100046C
Pays : United States
Organisme : NIEHS NIH HHS
ID : P30 ES000260
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA008748
Pays : United States
Organisme : NCI NIH HHS
ID : HHSN261201000034C
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA134674
Pays : United States
Organisme : NCI NIH HHS
ID : N01 PC067009
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201100001I
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA016087
Pays : United States
Organisme : NCI NIH HHS
ID : HHSN261201000140C
Pays : United States
Organisme : NCI NIH HHS
ID : N01 PC067010
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA098122
Pays : United States
Organisme : NHGRI NIH HHS
ID : U01 HG007033
Pays : United States
Organisme : NCI NIH HHS
ID : P01 CA087969
Pays : United States
Organisme : NCI NIH HHS
ID : HHSN261201000035C
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA134958
Pays : United States
Organisme : NCI NIH HHS
ID : R21 CA165923
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201100004I
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA086862
Pays : United States
Organisme : NCI NIH HHS
ID : U01 CA167552
Pays : United States
Organisme : NCI NIH HHS
ID : N01 PC067008
Pays : United States
Organisme : WHI NIH HHS
ID : HHSN268201100003C
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA148690
Pays : United States
Organisme : Blood Cancer UK
ID : 22015
Pays : United Kingdom
Organisme : NCCDPHP CDC HHS
ID : U58 DP000807
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA154643
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA062006
Pays : United States
Organisme : NCI NIH HHS
ID : N01 PC065064
Pays : United States
Organisme : NCI NIH HHS
ID : K08 CA134919
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR000135
Pays : United States
Organisme : NIA NIH HHS
ID : HHSN271201100004C
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA098661
Pays : United States
Organisme : NCI NIH HHS
ID : UM1 CA186107
Pays : United States
Organisme : WHI NIH HHS
ID : HHSN268201100002C
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA015083
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA092153
Pays : United States
Organisme : Intramural NIH HHS
ID : ZIA CP010136
Pays : United States
Organisme : NCI NIH HHS
ID : HHSN261201000035I
Pays : United States
Organisme : NCI NIH HHS
ID : P50 CA097274
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201100003I
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA049449
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201100002I
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA200703
Pays : United States
Organisme : NCI NIH HHS
ID : N01CO12400
Pays : United States
Organisme : CCR NIH HHS
ID : HHSN261200800001C
Pays : United States
Organisme : NCI NIH HHS
ID : U01 CA049449
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA149445
Pays : United States
Organisme : NCI NIH HHS
ID : HHSN261201000026C
Pays : United States
Organisme : WHI NIH HHS
ID : HHSN268201100001C
Pays : United States
Organisme : WHI NIH HHS
ID : HHSN268201100004C
Pays : United States
Organisme : NCI NIH HHS
ID : U01 CA118444
Pays : United States
Organisme : NCI NIH HHS
ID : HHSN261200800001E
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA042014
Pays : United States
Déclaration de conflit d'intérêts
Conflicts of interest All authors declare that there are no conflicts of interest.
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