Adolescent cognitive function and incident early-onset type 2 diabetes.
Adolescent
Cognitive scores
Cognitive subdomains
Type 2 diabetes
Journal
EClinicalMedicine
ISSN: 2589-5370
Titre abrégé: EClinicalMedicine
Pays: England
ID NLM: 101733727
Informations de publication
Date de publication:
Nov 2021
Nov 2021
Historique:
received:
21
07
2021
revised:
29
08
2021
accepted:
06
09
2021
entrez:
8
10
2021
pubmed:
9
10
2021
medline:
9
10
2021
Statut:
epublish
Résumé
Cognitive function among apparently healthy adolescents has been associated with cardiovascular morbidity and mortality. We examined the relationship between global and subdomain cognitive scores in adolescence and early-onset type 2 diabetes (T2D) in men and women. A nationwide, population-based study of 971,677 Israeli born adolescents (56% men; mean age 17.4 years) who were medically examined and their cognitive performance was assessed before compulsory military service during 1992-2010. Data included global and subdomain cognitive During 16,095,122 person-years, 3,570 individuals developed T2D. After adjustment, those in the low compared to the high quintile of global cognitive This large nationally representative cohort suggests relationship between global, as well as subdomain cognitive scores in late adolescence, and incident early onset T2D in both sexes, which was independent of socioeconomic status.
Sections du résumé
BACKGROUND
BACKGROUND
Cognitive function among apparently healthy adolescents has been associated with cardiovascular morbidity and mortality. We examined the relationship between global and subdomain cognitive scores in adolescence and early-onset type 2 diabetes (T2D) in men and women.
METHODS
METHODS
A nationwide, population-based study of 971,677 Israeli born adolescents (56% men; mean age 17.4 years) who were medically examined and their cognitive performance was assessed before compulsory military service during 1992-2010. Data included global and subdomain cognitive
FINDINGS
RESULTS
During 16,095,122 person-years, 3,570 individuals developed T2D. After adjustment, those in the low compared to the high quintile of global cognitive
INTERPRETATION
CONCLUSIONS
This large nationally representative cohort suggests relationship between global, as well as subdomain cognitive scores in late adolescence, and incident early onset T2D in both sexes, which was independent of socioeconomic status.
Identifiants
pubmed: 34622185
doi: 10.1016/j.eclinm.2021.101138
pii: S2589-5370(21)00418-1
pmc: PMC8479622
doi:
Types de publication
Journal Article
Langues
eng
Pagination
101138Informations de copyright
© 2021 The Author(s).
Déclaration de conflit d'intérêts
All authors have completed the ICMJE uniform disclosure form and declare: no support from any organization for the submitted article. Dr Gerstein reports grants from Sanofi, personal fees from Sanofi, grants from Eli Lilly , personal fees from Eli Lilly, grants from Astra Zeneca, grants from Boehringer Ingelheim, personal fees from Boehringer Ingelheim, personal fees from Abbott, grants from Novo Nordisk, personal fees from Novo Nordisk, grants from Merck, personal fees from Merck, grants from Abbott, personal fees from Kowa Research Institute , personal fees from Pfizer, personal fees from Zuellig, personal fees from DKSH, personal fees from Covance, personal fees from Roche, outside the submitted work. Dr. Raz reports other from AstraZeneca, Eli Lilly and Company, Merck Sharp & Dohme, Novo Nordisk, Inc, Sanofi, other from AstraZeneca, Insuline Medical, Medial EarlySign Ltd, CamerEyes Ltd, Exscopia, Orgenesis Ltd, BOL, Glucome Ltd, DarioHealth, Diabot, Concenter BioPharma, other from AstraZeneca, Eli Lilly and Company, Merck Sharp & Dohme, Novo Nordisk, Inc., Sanofi, other from Glucome Ltd, Orgenesis Ltd, DarioHealth, CamerEyes Ltd, Diabot, BOL, outside the submitted work. All the other authors have no conflicts to declare.
Références
Lancet Diabetes Endocrinol. 2018 Jan;6(1):69-80
pubmed: 28847479
Cardiovasc Diabetol. 2018 Dec 5;17(1):154
pubmed: 30518353
Diabetologia. 2008 Mar;51(3):436-43
pubmed: 18204831
Psychol Med. 2018 Sep;48(12):2011-2022
pubmed: 29239293
Intelligence. 2009 Nov;37(6):567-572
pubmed: 23226908
Physiol Rev. 2016 Oct;96(4):1169-209
pubmed: 27489306
Diabetes Care. 2020 Jul;43(7):1487-1495
pubmed: 32321731
Diabetes Care. 2008 Mar;31(3):514-6
pubmed: 18083794
Diabetes Care. 2021 Jan;44(1):e6-e8
pubmed: 33148634
Nat Hum Behav. 2021 Apr;5(4):416-430
pubmed: 33795857
Epidemiology. 2013 Sep;24(5):632-6
pubmed: 23863323
Psychol Health Med. 2017 Sep;22(8):1001-1010
pubmed: 27852112
Diabetes Care. 2014 Nov;37(11):2982-8
pubmed: 25092683
Epidemiology. 2017 Jul;28(4):608-618
pubmed: 28410350
J Epidemiol Community Health. 2003 Jun;57(6):464-5
pubmed: 12775797
Int J Epidemiol. 2011 Jun;40(3):626-44
pubmed: 21037248
Diabetologia. 2010 Jan;53(1):58-65
pubmed: 19882137
Diabetologia. 2018 Sep;61(9):1946-1955
pubmed: 29860628
Diabetes. 2014 Jul;63(7):2232-43
pubmed: 24931034
Int J Epidemiol. 2011 Jun;40(3):804-18
pubmed: 21335614
Can J Cardiol. 2017 Feb;33(2):232-242
pubmed: 27956044
Curr Opin Neurobiol. 2016 Jun;38:53-6
pubmed: 26953847
J Psychosom Res. 2013 Sep;75(3):275-8
pubmed: 23972418
Lancet Diabetes Endocrinol. 2014 Mar;2(3):246-55
pubmed: 24622755
Am J Epidemiol. 2013 Nov 1;178(9):1461-8
pubmed: 24029684