Retinoic acid signaling is directly activated in cardiomyocytes and protects mouse hearts from apoptosis after myocardial infarction.
developmental biology
heart development
mouse
myocardial infarction
regenerative medicine
retinoic acid signaling
stem cells
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
08 10 2021
08 10 2021
Historique:
received:
14
03
2021
accepted:
07
10
2021
pubmed:
9
10
2021
medline:
15
12
2021
entrez:
8
10
2021
Statut:
epublish
Résumé
Retinoic acid (RA) is an essential signaling molecule for cardiac development and plays a protective role in the heart after myocardial infarction (MI). In both cases, the effect of RA signaling on cardiomyocytes, the principle cell type of the heart, has been reported to be indirect. Here we have developed an inducible murine transgenic RA-reporter line using CreER
Identifiants
pubmed: 34623260
doi: 10.7554/eLife.68280
pii: 68280
pmc: PMC8530512
doi:
pii:
Substances chimiques
Tretinoin
5688UTC01R
Aldehyde Dehydrogenase
EC 1.2.1.3
Banques de données
GEO
['GSE161429']
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© 2021, Da Silva et al.
Déclaration de conflit d'intérêts
FD, FJ, LW, AT, SB, JL, PD, NG, KW, AS No competing interests declared
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