Estrogen receptors and the aging brain.
Ageing
Alzheimer's disease
Estrogen receptor
Parkinson's disease
Sex differences
Sex hormones
Journal
Essays in biochemistry
ISSN: 1744-1358
Titre abrégé: Essays Biochem
Pays: England
ID NLM: 0043306
Informations de publication
Date de publication:
17 12 2021
17 12 2021
Historique:
received:
14
06
2021
revised:
09
09
2021
accepted:
10
09
2021
pubmed:
9
10
2021
medline:
5
4
2022
entrez:
8
10
2021
Statut:
ppublish
Résumé
The female sex hormone estrogen has been ascribed potent neuroprotective properties. It signals by binding and activating estrogen receptors that, depending on receptor subtype and upstream or downstream effectors, can mediate gene transcription and rapid non-genomic actions. In this way, estrogen receptors in the brain participate in modulating neural differentiation, proliferation, neuroinflammation, cholesterol metabolism, synaptic plasticity, and behavior. Circulating sex hormones decrease in the course of aging, more rapidly at menopause in women, and slower in men. This review will discuss what this drop entails in terms of modulating neuroprotection and resilience in the aging brain downstream of spatiotemporal estrogen receptor alpha (ERα) and beta (ERβ) signaling, as well as in terms of the sex differences observed in Alzheimer's disease (AD) and Parkinson's disease (PD). In addition, controversies related to ER expression in the brain will be discussed. Understanding the spatiotemporal signaling of sex hormones in the brain can lead to more personalized prevention strategies or therapies combating neurodegenerative diseases.
Identifiants
pubmed: 34623401
pii: 229897
doi: 10.1042/EBC20200162
pmc: PMC8628183
doi:
Substances chimiques
Receptors, Estrogen
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
913-925Subventions
Organisme : NIA NIH HHS
ID : R01 AG065209
Pays : United States
Informations de copyright
© 2021 The Author(s).
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