SARS-CoV-2 wastewater surveillance data can predict hospitalizations and ICU admissions.

COVID-19 Hospitalization Humans Intensive Care Units RNA, Viral SARS-CoV-2 Wastewater Wastewater-Based Epidemiological Monitoring
COVID-19 Hospital admission rates ICU admission rates Method validation RT-qPCR Wastewater-based epidemiology

Journal

The Science of the total environment
ISSN: 1879-1026
Titre abrégé: Sci Total Environ
Pays: Netherlands
ID NLM: 0330500

Informations de publication

Date de publication:
15 Jan 2022
Historique:
received: 29 07 2021
revised: 31 08 2021
accepted: 01 09 2021
pubmed: 9 10 2021
medline: 20 11 2021
entrez: 8 10 2021
Statut: ppublish

Résumé

We measured SARS-CoV-2 RNA load in raw wastewater in Attica, Greece, by RT-qPCR for the environmental surveillance of COVID-19 for 6 months. The lag between RNA load and pandemic indicators (COVID-19 hospital and intensive care unit (ICU) admissions) was calculated using a grid search. Our results showed that RNA load in raw wastewater is a leading indicator of positive COVID-19 cases, new hospitalization and admission into ICUs by 5, 8 and 9 days, respectively. Modelling techniques based on distributed/fixed lag modelling, linear regression and artificial neural networks were utilized to build relationships between SARS-CoV-2 RNA load in wastewater and pandemic health indicators. SARS-CoV-2 mutation analysis in wastewater during the third pandemic wave revealed that the alpha-variant was dominant. Our results demonstrate that clinical and environmental surveillance data can be combined to create robust models to study the on-going COVID-19 infection dynamics and provide an early warning for increased hospital admissions.

Identifiants

DOI: 10.1016/j.scitotenv.2021.150151 PMID: 34623953 PMC: PMC8421077
pubmed: 34623953
pii: S0048-9697(21)05228-1
doi: 10.1016/j.scitotenv.2021.150151
pmc: PMC8421077
pii:
doi:

Substances chimiques

RNA, Viral 0
Waste Water 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

150151

Subventions

Organisme : NCATS NIH HHS
ID : UL1 TR001863
Pays : United States

Informations de copyright

Copyright © 2021 Elsevier B.V. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of competing interest Provisional patent applications entitled “Detection and mutational analysis of an RNA virus in an environmental sample” were filed by the National and Kapodistrian University of Athens, and the authors Andreas Scorilas, Margaritis Avgeris, Panagiotis G. Adamopoulos and Nikolaos S. Thomaidis on February 11, 2021 to the Hellenic Industrial Property Organisation (Case Number: 231-0004089064) and on March 22, 2021 to the Patent Cooperation Treaty (PCT application number: PCT/EP2021/057316). All other authors declare no competing interests.

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Auteurs

Aikaterini Galani (A)

Laboratory of Analytical Chemistry, Department of Chemistry, National and Kapodistrian University of Athens, University Campus, Zografou, 15771, Athens, Greece.

Reza Aalizadeh (R)

Laboratory of Analytical Chemistry, Department of Chemistry, National and Kapodistrian University of Athens, University Campus, Zografou, 15771, Athens, Greece.

Marios Kostakis (M)

Laboratory of Analytical Chemistry, Department of Chemistry, National and Kapodistrian University of Athens, University Campus, Zografou, 15771, Athens, Greece.

Athina Markou (A)

Laboratory of Analytical Chemistry, Department of Chemistry, National and Kapodistrian University of Athens, University Campus, Zografou, 15771, Athens, Greece.

Nikiforos Alygizakis (N)

Laboratory of Analytical Chemistry, Department of Chemistry, National and Kapodistrian University of Athens, University Campus, Zografou, 15771, Athens, Greece.

Theodore Lytras (T)

School of Medicine, European University Cyprus, Cyprus.

Panagiotis G Adamopoulos (PG)

Department of Biochemistry and Molecular Biology, Faculty of Biology, National and Kapodistrian University of Athens, Athens, Greece.

Jordan Peccia (J)

Department of Chemical and Environmental Engineering, School of Engineering and Applied Science, Yale University, New Haven, CT, USA.

David C Thompson (DC)

Department of Clinical Pharmacy, School of Pharmacy and Pharmaceutical Sciences, University of Colorado Skaggs, Aurora, CO, USA; Department of Environmental Health Sciences, Yale School of Public Health, Yale University, New Haven, CT 06510, USA.

Aikaterini Kontou (A)

Laboratory of Analytical Chemistry, Department of Chemistry, National and Kapodistrian University of Athens, University Campus, Zografou, 15771, Athens, Greece.

Apostolos Karagiannidis (A)

Laboratory of Analytical Chemistry, Department of Chemistry, National and Kapodistrian University of Athens, University Campus, Zografou, 15771, Athens, Greece.

Evi S Lianidou (ES)

Laboratory of Analytical Chemistry, Department of Chemistry, National and Kapodistrian University of Athens, University Campus, Zografou, 15771, Athens, Greece.

Margaritis Avgeris (M)

Department of Biochemistry and Molecular Biology, Faculty of Biology, National and Kapodistrian University of Athens, Athens, Greece; Laboratory of Clinical Biochemistry - Molecular Diagnostics, Second Department of Pediatrics, "P. & A. Kyriakou" Children's Hospital, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.

Dimitrios Paraskevis (D)

Department of Hygiene Epidemiology and Medical Statistics, School of Medicine, National and Kapodistrian University of Athens, 11527 Athens, Greece.

Sotirios Tsiodras (S)

Fourth Department of Internal Medicine, School of Medicine, University General Hospital Attikon, National and Kapodistrian University of Athens, Greece.

Andreas Scorilas (A)

Department of Biochemistry and Molecular Biology, Faculty of Biology, National and Kapodistrian University of Athens, Athens, Greece.

Vasilis Vasiliou (V)

Department of Environmental Health Sciences, Yale School of Public Health, Yale University, New Haven, CT 06510, USA.

Meletios-Athanasios Dimopoulos (MA)

Department of Clinical Therapeutics, School of Medicine, National and Kapodistrian University of Athens, Greece.

Nikolaos S Thomaidis (NS)

Laboratory of Analytical Chemistry, Department of Chemistry, National and Kapodistrian University of Athens, University Campus, Zografou, 15771, Athens, Greece. Electronic address: ntho@chem.uoa.gr.

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Classifications MeSH

questionsmedicales.fr › Maladies de l'appareil respiratoire › Infections de l'appareil respiratoire › Pneumopathie infectieuse › Pneumopathie virale › COVID-19 › SARS-CoV-2 wastewater surveillance data can...
questionsmedicales.fr › Établissements, main d'oeuvre et services de soins de santé › Services de santé › Soins aux patients › Hospitalisation › SARS-CoV-2 wastewater surveillance data can...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › SARS-CoV-2 wastewater surveillance data can...
questionsmedicales.fr › Établissements, main d'oeuvre et services de soins de santé › Établissements de santé › Unités hospitalières › Unités de soins intensifs › SARS-CoV-2 wastewater surveillance data can...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › ARN viral › SARS-CoV-2 wastewater surveillance data can...
questionsmedicales.fr › Virus › Virus à ARN › Virus à ARN à brin positif › Nidovirales › Coronaviridae › Coronavirus › Betacoronavirus › Virus du SRAS › SARS-CoV-2 › SARS-CoV-2 wastewater surveillance data can...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Pollution de l'environnement › Déchets › Eaux usées › SARS-CoV-2 wastewater surveillance data can...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Surveillance épidémiologique › Surveillance épidémiologique fondée sur les eaux usées › SARS-CoV-2 wastewater surveillance data can...