Generation of four severe early-onset chronic obstructive pulmonary disease (COPD) patient-derived induced pluripotent stem cell lines from peripheral blood mononuclear cells.
Journal
Stem cell research
ISSN: 1876-7753
Titre abrégé: Stem Cell Res
Pays: England
ID NLM: 101316957
Informations de publication
Date de publication:
10 2021
10 2021
Historique:
received:
06
05
2021
revised:
06
09
2021
accepted:
19
09
2021
pubmed:
9
10
2021
medline:
26
11
2021
entrez:
8
10
2021
Statut:
ppublish
Résumé
Evidence highlights the concept of multiple trajectories leading to COPD. Early-life events (i.e., in utero lung development) may influence the maximally attained lung function and increase the risk to develop COPD. Human pluripotent stem cells (hiPSC) represent a unique opportunity to model lung development. We generated hiPSC lines from four highly characterized COPD patients with early onset and severe phenotype. Peripheral blood mononuclear cells (PBMCs) were reprogrammed using integration-free Sendai Virus. The cell lines had normal karyotype, expressed pluripotency hallmarks, and differentiated into the three primary germ layers. These lines offer a tool to study early-life origins of COPD.
Identifiants
pubmed: 34624616
pii: S1873-5061(21)00397-4
doi: 10.1016/j.scr.2021.102550
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
102550Informations de copyright
Copyright © 2021 CHU de Montpellier. Published by Elsevier B.V. All rights reserved.