Role of hippocampal NF-κB and GluN2B in the memory acquisition impairment of experiences gathered prior to cocaine administration in rats.
Anesthetics, Local
/ administration & dosage
Animals
Behavior, Animal
/ drug effects
Cocaine
/ administration & dosage
Gene Expression Regulation
/ drug effects
Male
Memory Consolidation
/ drug effects
Memory Disorders
/ chemically induced
NF-kappa B
/ genetics
Rats
Rats, Wistar
Receptors, N-Methyl-D-Aspartate
/ genetics
Spatial Memory
/ drug effects
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
08 10 2021
08 10 2021
Historique:
received:
25
11
2020
accepted:
16
09
2021
entrez:
9
10
2021
pubmed:
10
10
2021
medline:
27
1
2022
Statut:
epublish
Résumé
Cocaine can induce severe neurobehavioral changes, among others, the ones involved in learning and memory processes. It is known that during drug consumption, cocaine-associated memory and learning processes take place. However, much less is known about the effects of this drug upon the mechanisms involved in forgetting.The present report focuses on the mechanisms by which cocaine affects memory consolidation of experiences acquired prior to drug administration. We also study the involvement of hippocampus in these processes, with special interest on the role of Nuclear factor kappa B (NF-κB), N-methyl-D-aspartate glutamate receptor 2B (GluN2B), and their relationship with other proteins, such as cyclic AMP response element binding protein (CREB). For this purpose, we developed a rat experimental model of chronic cocaine administration in which spatial memory and the expression or activity of several proteins in the hippocampus were assessed after 36 days of drug administration. We report an impairment in memory acquisition of experiences gathered prior to cocaine administration, associated to an increase in GluN2B expression in the hippocampus. We also demonstrate a decrease in NF-κB activity, as well as in the expression of the active form of CREB, confirming the role of these transcription factors in the cocaine-induced memory impairment.
Identifiants
pubmed: 34625609
doi: 10.1038/s41598-021-99448-w
pii: 10.1038/s41598-021-99448-w
pmc: PMC8501066
doi:
Substances chimiques
Anesthetics, Local
0
NF-kappa B
0
NR2B NMDA receptor
0
Receptors, N-Methyl-D-Aspartate
0
Cocaine
I5Y540LHVR
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
20033Informations de copyright
© 2021. The Author(s).
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