SARS-CoV-2 inhibition using a mucoadhesive, amphiphilic chitosan that may serve as an anti-viral nasal spray.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
08 10 2021
08 10 2021
Historique:
received:
16
12
2020
accepted:
22
09
2021
entrez:
9
10
2021
pubmed:
10
10
2021
medline:
25
2
2023
Statut:
epublish
Résumé
There are currently no cures for coronavirus infections, making the prevention of infections the only course open at the present time. The COVID-19 pandemic has been difficult to prevent, as the infection is spread by respiratory droplets and thus effective, scalable and safe preventive interventions are urgently needed. We hypothesise that preventing viral entry into mammalian nasal epithelial cells may be one way to limit the spread of COVID-19. Here we show that N-palmitoyl-N-monomethyl-N,N-dimethyl-N,N,N-trimethyl-6-O-glycolchitosan (GCPQ), a positively charged polymer that has been through an extensive Good Laboratory Practice toxicology screen, is able to reduce the infectivity of SARS-COV-2 in A549
Identifiants
pubmed: 34625610
doi: 10.1038/s41598-021-99404-8
pii: 10.1038/s41598-021-99404-8
pmc: PMC8501059
doi:
Substances chimiques
Antiviral Agents
0
Nasal Sprays
0
Surface-Active Agents
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
20012Informations de copyright
© 2021. The Author(s).
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