Anti-leishmanial compounds from microbial metabolites: a promising source.
Bioactive compounds
Leishmaniasis
Microbial metabolites
Scientific database
Secondary metabolites
Journal
Applied microbiology and biotechnology
ISSN: 1432-0614
Titre abrégé: Appl Microbiol Biotechnol
Pays: Germany
ID NLM: 8406612
Informations de publication
Date de publication:
Nov 2021
Nov 2021
Historique:
received:
13
07
2021
accepted:
20
09
2021
revised:
18
09
2021
pubmed:
10
10
2021
medline:
3
11
2021
entrez:
9
10
2021
Statut:
ppublish
Résumé
Leishmania is a complex disease caused by the protozoan parasites and transmitted by female phlebotomine sandfly. The disease affects some of the poorest people on earth with an estimated 700,000 to 1 million new cases annually. The current treatment for leishmaniasis is toxic, long, and limited, in view of the high resistance rate presented by the parasite, necessitating new perspectives for treatment. The discovery of new compounds with different targets can be a hope to make the treatment more efficient. Microbial metabolites and their structural analogues with enormous scaffold diversity and structural complexity have historically played a key role in drug discovery. We found thirty-nine research articles published between 1999 and 2021 in the scientific database (PubMed, Science Direct) describing microbes and their metabolites with activity against leishmanial parasites which is the focus of this review. KEY POINTS: • Leishmania affects the poorest regions of the globe • Current treatments for leishmaniasis are toxic and of limited efficacy • Microbial metabolites are potential sources of antileishmania drugs.
Identifiants
pubmed: 34625819
doi: 10.1007/s00253-021-11610-6
pii: 10.1007/s00253-021-11610-6
doi:
Substances chimiques
Antiprotozoal Agents
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
8227-8240Informations de copyright
© 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
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