Altered Gut Microbiota Profile in Lin28a Transgenic Mice Can Improve Glucose Tolerance.
Lin28a Tg mice
glucose metabolism
gut microbiota
Journal
Bulletin of experimental biology and medicine
ISSN: 1573-8221
Titre abrégé: Bull Exp Biol Med
Pays: United States
ID NLM: 0372557
Informations de publication
Date de publication:
Sep 2021
Sep 2021
Historique:
received:
09
10
2020
pubmed:
10
10
2021
medline:
10
2
2022
entrez:
9
10
2021
Statut:
ppublish
Résumé
Recent studies showed that gut microbiota can be implicated in the control over glucose metabolism in the host organism. This study employed the Lin28a transgenic mice (Lin28a Tg) characterized by low fasting glucose levels and improved glucose tolerance test in comparison with the wild type species. 16S rDNA gene sequencing showed that the transgenic mice were distinguished by altered species richness of microbiota. Specifically, Lin28a Tg mice displayed higher abundance of Proteobacteria, Bacteroides, Parabacteroides, and lower abundance of Firmicutes known to be closely implicated in glucose metabolism. These data suggest that the peculiar profile of gut microbiota in Lin28a Tg mice can be directly involved in the control of glucose metabolism in the host organism.
Identifiants
pubmed: 34626282
doi: 10.1007/s10517-021-05286-1
pii: 10.1007/s10517-021-05286-1
doi:
Substances chimiques
Lin-28 protein, mouse
0
RNA-Binding Proteins
0
Glucose
IY9XDZ35W2
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
644-650Informations de copyright
© 2021. Springer Science+Business Media, LLC, part of Springer Nature.
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