Plethysmographic assessment of tidal expiratory flow limitation.
COPD
Expiratory resistance
Inspiratory resistance
Plethysmograph
Tidal flow-limitation
Journal
Respiratory physiology & neurobiology
ISSN: 1878-1519
Titre abrégé: Respir Physiol Neurobiol
Pays: Netherlands
ID NLM: 101140022
Informations de publication
Date de publication:
02 2022
02 2022
Historique:
received:
04
09
2021
revised:
29
09
2021
accepted:
01
10
2021
pubmed:
10
10
2021
medline:
3
3
2022
entrez:
9
10
2021
Statut:
ppublish
Résumé
Chronic obstructive pulmonary disease (COPD) patients often experience tidal expiratory flow-limitation (tEFL), a condition causing respiratory and cardiovascular detrimental effects. As the appearance of tEFL should increase expiratory (Rexp) relative to inspiratory (Rins) resistance, we hypothesized that Rexp/Rins can be used to detect tEFL. Rexp/Rins was measured with a commercial plethysmograph in 109 healthy subjects and, before and after bronchodilation (BD), in 64 COPD patients, 36 with and 28 without tEFL according to the NEP technique. Before BD, the median (interquartile range) of Rexp/Rins was significantly greater (P < 0.001) in COPD patients with tEFL (2.47(3.06;7.07)) than in COPD patients without tEFL (1.63(1.44;1.82)) and in healthy subjects (1.52(1.35;1.62)). In COPD patients Rexp/Rins above 1.98 predicted the presence of tEFL with 96 % specificity and 92 % sensitivity, Rexp
Identifiants
pubmed: 34626830
pii: S1569-9048(21)00187-7
doi: 10.1016/j.resp.2021.103801
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
103801Informations de copyright
Copyright © 2021. Published by Elsevier B.V.