A Schizophyllum commune fungus ball in a lung cancer cavity: a case report.
Fungal ball
Internal transcribed spacer sequencing
Lung cancer cavity
Schizophyllum commune
Journal
BMC infectious diseases
ISSN: 1471-2334
Titre abrégé: BMC Infect Dis
Pays: England
ID NLM: 100968551
Informations de publication
Date de publication:
09 Oct 2021
09 Oct 2021
Historique:
received:
02
08
2021
accepted:
27
09
2021
entrez:
10
10
2021
pubmed:
11
10
2021
medline:
13
10
2021
Statut:
epublish
Résumé
Schizophyllum commune is a basidiomycete that lives in the environment and can cause infections, mainly those of the respiratory system. Although S. commune is increasingly reported as a cause of allergic bronchopulmonary mycosis and sinusitis, cases of fungal ball formation are extremely uncommon. Identification of S. commune is difficult using routine mycological diagnostic methods, and in clinically suspicious cases, internal transcribed spacer sequencing should be used for diagnosis. Here, we report a first case of lung cancer with a fungal ball formation of S. commune, confirmed by analyzing the internal transcribed spacer. A 76-year-old man with diabetes and hypertension was admitted to the hospital with a chief complaint of hemosputum, which he had for about 19 months. A computed tomography image of the patient's chest showed a cavity and internal nodule in the left upper lobe of his lung. A left upper lobectomy was performed, and histopathological examination revealed squamous cell carcinoma of the lung and a fungal ball. The isolate from the surgical specimen was identified as S. commune by analyzing the internal transcribed spacer. The patient had no recurrence of the infection during 5 months of follow-up. Only three cases of lung fungal balls caused by S. commune have been previously reported, and this is the first case of lung cancer cavity with a fungal ball formation. In cases of fungal ball formation in the lung, S. commune should be considered a possible causative microorganism.
Sections du résumé
BACKGROUND
BACKGROUND
Schizophyllum commune is a basidiomycete that lives in the environment and can cause infections, mainly those of the respiratory system. Although S. commune is increasingly reported as a cause of allergic bronchopulmonary mycosis and sinusitis, cases of fungal ball formation are extremely uncommon. Identification of S. commune is difficult using routine mycological diagnostic methods, and in clinically suspicious cases, internal transcribed spacer sequencing should be used for diagnosis. Here, we report a first case of lung cancer with a fungal ball formation of S. commune, confirmed by analyzing the internal transcribed spacer.
CASE PRESENTATION
METHODS
A 76-year-old man with diabetes and hypertension was admitted to the hospital with a chief complaint of hemosputum, which he had for about 19 months. A computed tomography image of the patient's chest showed a cavity and internal nodule in the left upper lobe of his lung. A left upper lobectomy was performed, and histopathological examination revealed squamous cell carcinoma of the lung and a fungal ball. The isolate from the surgical specimen was identified as S. commune by analyzing the internal transcribed spacer. The patient had no recurrence of the infection during 5 months of follow-up.
CONCLUSIONS
CONCLUSIONS
Only three cases of lung fungal balls caused by S. commune have been previously reported, and this is the first case of lung cancer cavity with a fungal ball formation. In cases of fungal ball formation in the lung, S. commune should be considered a possible causative microorganism.
Identifiants
pubmed: 34627188
doi: 10.1186/s12879-021-06739-8
pii: 10.1186/s12879-021-06739-8
pmc: PMC8502358
doi:
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1052Informations de copyright
© 2021. The Author(s).
Références
Mycoses. 2011 Sep;54(5):e318-22
pubmed: 20557462
Mycol Res. 2007 May;111(Pt 5):509-47
pubmed: 17572334
J Infect Chemother. 2019 Sep;25(9):731-734
pubmed: 30905630
J Clin Microbiol. 2014 Feb;52(2):683-7
pubmed: 24478514
Nihon Kokyuki Gakkai Zasshi. 2001 Dec;39(12):961-5
pubmed: 11875816
J Mycol Med. 2019 Dec;29(4):365-371
pubmed: 31543381
World J Surg Oncol. 2011 Feb 27;9:27
pubmed: 21352593
Stud Mycol. 2019 Mar;92:135-154
pubmed: 29955203
J Clin Microbiol. 2007 Feb;45(2):568-71
pubmed: 17135442
Thorac Cancer. 2013 May;4(2):212-214
pubmed: 28920192
Antimicrob Agents Chemother. 2001 Feb;45(2):633-5
pubmed: 11158771
Antimicrob Agents Chemother. 2013 Jun;57(6):2845-8
pubmed: 23507274
Lung. 2018 Feb;196(1):1-10
pubmed: 29143119
Med Mycol. 2008 Nov;46(7):735-8
pubmed: 18654917
Can J Surg. 2008 Feb;51(1):E3-4
pubmed: 18248719
J Clin Microbiol. 1995 Aug;33(8):1979-83
pubmed: 7559933
QJM. 2015 May;108(5):431
pubmed: 25660602
BMC Microbiol. 2005 May 18;5:28
pubmed: 15904497
Intern Med. 2000 Feb;39(2):160-2
pubmed: 10732837
J Thorac Imaging. 2002 Jan;17(1):84-8
pubmed: 11828219
Mycoses. 2013 Jan;56(1):1-10
pubmed: 22524529
Med Mycol. 2015 Nov;53(8):898-9
pubmed: 26472779
Int J Surg Case Rep. 2013;4(8):690-2
pubmed: 23792483