Layer 6A Pyramidal Cell Subtypes Form Synaptic Microcircuits with Distinct Functional and Structural Properties.
barrel cortex
cortico-claustral
cortico-cortical
cortico-thalamic
layer 6A
Journal
Cerebral cortex (New York, N.Y. : 1991)
ISSN: 1460-2199
Titre abrégé: Cereb Cortex
Pays: United States
ID NLM: 9110718
Informations de publication
Date de publication:
14 05 2022
14 05 2022
Historique:
received:
24
05
2021
revised:
03
08
2021
accepted:
25
08
2021
pubmed:
11
10
2021
medline:
20
5
2022
entrez:
10
10
2021
Statut:
ppublish
Résumé
Neocortical layer 6 plays a crucial role in sensorimotor co-ordination and integration through functionally segregated circuits linking intracortical and subcortical areas. We performed whole-cell recordings combined with morphological reconstructions to identify morpho-electric types of layer 6A pyramidal cells (PCs) in rat barrel cortex. Cortico-thalamic (CT), cortico-cortical (CC), and cortico-claustral (CCla) PCs were classified based on their distinct morphologies and have been shown to exhibit different electrophysiological properties. We demonstrate that these three types of layer 6A PCs innervate neighboring excitatory neurons with distinct synaptic properties: CT PCs establish weak facilitating synapses onto other L6A PCs; CC PCs form synapses of moderate efficacy, while synapses made by putative CCla PCs display the highest release probability and a marked short-term depression. For excitatory-inhibitory synaptic connections in layer 6, both the presynaptic PC type and the postsynaptic interneuron type govern the dynamic properties of the respective synaptic connections. We have identified a functional division of local layer 6A excitatory microcircuits which may be responsible for the differential temporal engagement of layer 6 feed-forward and feedback networks. Our results provide a basis for further investigations on the long-range CC, CT, and CCla pathways.
Identifiants
pubmed: 34628499
pii: 6385798
doi: 10.1093/cercor/bhab340
pmc: PMC9113278
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2095-2111Informations de copyright
© The Author(s) 2021. Published by Oxford University Press.
Références
Cereb Cortex. 2017 Feb 1;27(2):1011-1026
pubmed: 26637449
Cell Rep. 2019 Sep 17;28(12):3131-3143.e5
pubmed: 31533036
Front Syst Neurosci. 2014 May 19;8:93
pubmed: 24904315
Nat Rev Neurosci. 2009 Oct;10(10):724-35
pubmed: 19763105
Exp Brain Res. 1995;104(1):41-54
pubmed: 7621940
Nat Neurosci. 2019 Jul;22(7):1182-1195
pubmed: 31209381
Front Neuroanat. 2010 Mar 31;4:13
pubmed: 20556241
J Neurophysiol. 2002 Oct;88(4):1924-32
pubmed: 12364518
Nat Protoc. 2012 Feb 02;7(2):394-407
pubmed: 22301777
Front Neuroinform. 2014 Feb 05;8:5
pubmed: 24550819
Nature. 1999 Mar 25;398(6725):338-41
pubmed: 10192334
Cereb Cortex. 2018 May 1;28(5):1882-1897
pubmed: 29481606
Neuroscience. 1991;41(2-3):365-79
pubmed: 1870696
Nature. 2013 Nov 7;503(7474):51-8
pubmed: 24201278
Cereb Cortex. 2015 Mar;25(3):788-805
pubmed: 24108807
J Neurophysiol. 2004 Oct;92(4):2185-97
pubmed: 15140908
Cereb Cortex. 2019 Jul 5;29(7):3224-3242
pubmed: 30566584
Cereb Cortex. 1998 Jul-Aug;8(5):428-36
pubmed: 9722086
J Neurophysiol. 2008 Jun;99(6):2998-3008
pubmed: 18417631
J Neurosci. 2012 Apr 4;32(14):4992-5001
pubmed: 22492054
J Physiol. 2015 Oct 1;593(19):4499-510
pubmed: 26256545
J Neurosci. 2018 Jun 13;38(24):5441-5455
pubmed: 29798890
Neuroimage. 2019 Aug 15;197:772-784
pubmed: 28729159
Nat Rev Neurosci. 2013 Mar;14(3):202-16
pubmed: 23385869
J Neurosci. 1987 Apr;7(4):1223-49
pubmed: 3553446
Annu Rev Cell Dev Biol. 2015;31:699-720
pubmed: 26359774
J Neurophysiol. 2008 Oct;100(4):1909-22
pubmed: 18650305
J Neurosci. 1997 Aug 15;17(16):6365-79
pubmed: 9236245
Nature. 2021 Mar;591(7848):111-116
pubmed: 33442056
J Neurosci. 2014 Jul 16;34(29):9656-64
pubmed: 25031405
Nat Neurosci. 2020 Oct;23(10):1277-1285
pubmed: 32747790
Cereb Cortex. 2005 Oct;15(10):1485-96
pubmed: 15647524
Nature. 2021 Oct;598(7879):144-150
pubmed: 33184512
J Physiol. 2009 May 1;587(Pt 9):1889-96
pubmed: 19273572
Elife. 2018 Sep 26;7:
pubmed: 30256194
Neurosci Lett. 2007 Jul 5;422(1):77-80
pubmed: 17597301
J Comp Neurol. 1999 May 3;407(2):275-86
pubmed: 10213095
J Comp Neurol. 2017 Apr 15;525(6):1381-1402
pubmed: 26973027
Cereb Cortex. 2018 Jul 1;28(7):2340-2350
pubmed: 28591797
Brain Struct Funct. 2017 Jul;222(5):2041-2058
pubmed: 27714529
J Comp Neurol. 2018 Oct 15;526(15):2428-2443
pubmed: 30252130
Proc Natl Acad Sci U S A. 2013 Feb 26;110(9):3555-60
pubmed: 23401504
Science. 1995 Aug 18;269(5226):981-5
pubmed: 7638624
Science. 2000 Jan 14;287(5451):273-8
pubmed: 10634775
Science. 2016 Dec 23;354(6319):1587-1590
pubmed: 28008068
Cereb Cortex. 1999 Sep;9(6):569-76
pubmed: 10498275
Cereb Cortex. 2018 Aug 1;28(8):2763-2774
pubmed: 28981591
Neuron. 2014 Oct 1;84(1):238
pubmed: 28898623
Neuron. 2015 May 6;86(3):768-82
pubmed: 25913856
J Physiol. 2006 Sep 1;575(Pt 2):583-602
pubmed: 16793907
Cereb Cortex. 2010 Oct;20(10):2287-303
pubmed: 20534783
Elife. 2019 May 17;8:
pubmed: 31099752
J Neurosci. 2006 Apr 12;26(15):4026-35
pubmed: 16611819
Neuroscience. 2010 Mar 17;166(2):551-63
pubmed: 20040367
Cereb Cortex. 2020 May 18;30(6):3528-3542
pubmed: 32026946
Anat Embryol (Berl). 2000 Mar;201(3):169-79
pubmed: 10664178
Annu Rev Neurosci. 2020 Jul 8;43:231-247
pubmed: 32084328
J Neurosci. 1996 Apr 15;16(8):2701-15
pubmed: 8786446
Neuroscience. 2002;114(4):1033-45
pubmed: 12379257
Cereb Cortex. 1991 Sep-Oct;1(5):433-43
pubmed: 1822751
J Comp Neurol. 2017 Apr 15;525(6):1317-1346
pubmed: 27223051
Eur J Neurosci. 2010 Jun;31(12):2221-33
pubmed: 20550566
Nat Neurosci. 2020 Dec;23(12):1456-1468
pubmed: 32839617
J Comp Neurol. 2018 Jan 1;526(1):120-132
pubmed: 28884467
J Neurosci. 2003 Aug 13;23(19):7381-4
pubmed: 12917373
Front Syst Neurosci. 2014 Apr 04;8:44
pubmed: 24772069
Cell Rep. 2018 Jan 9;22(2):441-455
pubmed: 29320739
Front Neuroanat. 2019 Jun 19;13:64
pubmed: 31275119
Eur J Neurosci. 2014 Aug;40(4):2608-18
pubmed: 24827827
Curr Biol. 2018 Sep 10;28(17):2752-2762.e7
pubmed: 30122531
J Neurosci. 2016 Jan 20;36(3):773-84
pubmed: 26791208
Cereb Cortex. 2007 Sep;17(9):2204-13
pubmed: 17124287
Cell Rep. 2017 Dec 12;21(11):3065-3078
pubmed: 29241536
Cereb Cortex. 2017 Jul 1;27(7):3869-3878
pubmed: 28444185
J Physiol. 2002 Feb 1;538(Pt 3):803-22
pubmed: 11826166
Brain Res. 2005 Aug 2;1052(1):71-81
pubmed: 16018988
Cell. 2020 Nov 12;183(4):935-953.e19
pubmed: 33186530
Cereb Cortex. 2018 Apr 1;28(4):1439-1457
pubmed: 29329401
Neuron. 2021 Feb 3;109(3):545-559.e8
pubmed: 33290731
Cereb Cortex. 2009 Aug;19(8):1738-50
pubmed: 19008461
Cereb Cortex. 2012 Jun;22(6):1343-59
pubmed: 21862448
J Neurosci. 2010 Sep 29;30(39):12902-7
pubmed: 20881109
Epilepsy Res. 2018 Feb;140:97-104
pubmed: 29324357
Neuron. 2020 Jan 8;105(1):122-137.e8
pubmed: 31784285
Front Syst Neurosci. 2016 Dec 27;10:104
pubmed: 28082874
Cereb Cortex. 2015 Oct;25(10):3561-71
pubmed: 25205662
Cereb Cortex. 2021 Jan 1;31(1):32-47
pubmed: 32829414
Brain Struct Funct. 2018 Jul;223(6):2999-3006
pubmed: 29623428
Nature. 2016 Jan 7;529(7584):88-91
pubmed: 26738595
Curr Biol. 2020 Jul 20;30(14):2777-2790.e4
pubmed: 32531275
Cereb Cortex. 2006 Feb;16(2):200-11
pubmed: 15843627
J Physiol. 1999 Nov 15;521 Pt 1:169-90
pubmed: 10562343
J Comp Neurol. 2019 Feb 1;527(2):476-499
pubmed: 30225888
Nat Rev Neurosci. 2008 Jul;9(7):557-68
pubmed: 18568015
Front Neural Circuits. 2012 Mar 15;6:11
pubmed: 22435052
Neuroimage. 2010 Sep;52(3):897-912
pubmed: 20149881
Cereb Cortex. 2017 Dec 1;27(12):5755-5771
pubmed: 29028949
Science. 2003 Dec 12;302(5652):1981-4
pubmed: 14671309
Proc Natl Acad Sci U S A. 2008 Feb 12;105(6):2187-92
pubmed: 18245383
Cereb Cortex. 2009 Jun;19(6):1345-59
pubmed: 18842664
J Neurosci. 2008 Aug 13;28(33):8273-84
pubmed: 18701690
Cereb Cortex. 2013 Dec;23(12):2803-17
pubmed: 22944531
Neuron. 2014 Apr 16;82(2):474-85
pubmed: 24656931
J Neurosci. 2011 Jul 13;31(28):10380-91
pubmed: 21753015
Eur J Neurosci. 2012 Mar;35(6):855-69
pubmed: 22356566