Evaluation of intracellular processes in quinolinic acid-induced brain damage by imaging reactive oxygen species generation and mitochondrial complex I activity.
18F-BCPP-EF
Dihydroethidium
Microglia
Mitochondrial complex I
Quinolinic acid
Reactive oxygen species
Journal
EJNMMI research
ISSN: 2191-219X
Titre abrégé: EJNMMI Res
Pays: Germany
ID NLM: 101560946
Informations de publication
Date de publication:
09 Oct 2021
09 Oct 2021
Historique:
received:
27
04
2021
accepted:
17
09
2021
entrez:
10
10
2021
pubmed:
11
10
2021
medline:
11
10
2021
Statut:
epublish
Résumé
Our study aimed to elucidate the intracellular processes associated with quinolinic acid (QA)-induced brain injury by acquiring semiquantitative fluorescent images of reactive oxygen species (ROS) generation and positron emission tomography (PET) images of mitochondrial complex I (MC-I) activity. Ex vivo fluorescent imaging with dihydroethidium (DHE) and PET scans with A strong DHE-derived fluorescent signal was detected in a focal area within the QA-injected striatum 3 h after QA injection, and increased fluorescent signal spread throughout the striatum and parts of the cerebral cortex after 24 h. By contrast, We successfully obtained functional images of focal ROS generation during the early period of excitotoxic injury, and microglial ROS generation and mitochondrial dysfunction were observed during the progression of the inflammatory response. Both ex vivo DHE imaging and in vivo
Identifiants
pubmed: 34628558
doi: 10.1186/s13550-021-00841-3
pii: 10.1186/s13550-021-00841-3
pmc: PMC8502189
doi:
Types de publication
Journal Article
Langues
eng
Pagination
99Informations de copyright
© 2021. The Author(s).
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