Effect of domperidone (leisguard®) on antibody titers, inflammatory markers and creatinine in dogs with leishmaniosis and chronic kidney disease.
Acute-Phase Proteins
Animals
Antibodies, Protozoan
/ blood
Biomarkers
/ blood
Creatinine
/ blood
Dog Diseases
/ drug therapy
Dogs
Domperidone
/ therapeutic use
Female
Inflammation
/ blood
Leishmania infantum
/ drug effects
Leishmaniasis
/ drug therapy
Male
Pilot Projects
Prospective Studies
Renal Insufficiency, Chronic
/ blood
Antibody titer
CRP
Creatinine
Dog
Domperidone
Gamma globulins
Globulins
Leishmaniosis
Journal
Parasites & vectors
ISSN: 1756-3305
Titre abrégé: Parasit Vectors
Pays: England
ID NLM: 101462774
Informations de publication
Date de publication:
10 Oct 2021
10 Oct 2021
Historique:
received:
23
07
2021
accepted:
21
09
2021
entrez:
11
10
2021
pubmed:
12
10
2021
medline:
24
12
2021
Statut:
epublish
Résumé
Immunotherapeutic drugs, such as domperidone, have been shown to be promising treatments against canine leishmaniosis (CanL), but limited data are available. The aim of this pilot study (therapeutic, prospective and non-controlled) was to evaluate the effect of domperidone on serum antibody titers of Leishmania infantum, globulins, gamma globulins, acute-phase proteins (e.g. C-reactive protein [CRP]), big endothelin-1 (big ET-1), serum creatinine (SC) and proteinuria in dogs with leishmaniosis affected by chronic kidney disease (CKD). Dogs were recruited if "exposed" to or "infected" with L. infantum and affected by CKD (IRIS stage 1 [proteinuric] or IRIS stage 2-3a [SC < 3.5 mg/dl; proteinuric or non-proteinuric]). After inclusion, an oral suspension of domperidone was administered, and the dogs were followed up for 180 days, with checks at 30, 60, 90 and 180 days after initial treatment. Of the 14 recruited dogs, nine showed a statistically significant reduction in SC (χ This study provides preliminary results on the ability of domperidone to improve SC and reduce anti-L. infantum antibody titers, globulins, gamma globulins and CRP in dogs with leishmaniosis and CKD.
Sections du résumé
BACKGROUND
BACKGROUND
Immunotherapeutic drugs, such as domperidone, have been shown to be promising treatments against canine leishmaniosis (CanL), but limited data are available. The aim of this pilot study (therapeutic, prospective and non-controlled) was to evaluate the effect of domperidone on serum antibody titers of Leishmania infantum, globulins, gamma globulins, acute-phase proteins (e.g. C-reactive protein [CRP]), big endothelin-1 (big ET-1), serum creatinine (SC) and proteinuria in dogs with leishmaniosis affected by chronic kidney disease (CKD).
METHODS
METHODS
Dogs were recruited if "exposed" to or "infected" with L. infantum and affected by CKD (IRIS stage 1 [proteinuric] or IRIS stage 2-3a [SC < 3.5 mg/dl; proteinuric or non-proteinuric]). After inclusion, an oral suspension of domperidone was administered, and the dogs were followed up for 180 days, with checks at 30, 60, 90 and 180 days after initial treatment.
RESULTS
RESULTS
Of the 14 recruited dogs, nine showed a statistically significant reduction in SC (χ
CONCLUSIONS
CONCLUSIONS
This study provides preliminary results on the ability of domperidone to improve SC and reduce anti-L. infantum antibody titers, globulins, gamma globulins and CRP in dogs with leishmaniosis and CKD.
Identifiants
pubmed: 34629081
doi: 10.1186/s13071-021-05030-8
pii: 10.1186/s13071-021-05030-8
pmc: PMC8504065
doi:
Substances chimiques
Acute-Phase Proteins
0
Antibodies, Protozoan
0
Biomarkers
0
Domperidone
5587267Z69
Creatinine
AYI8EX34EU
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
525Subventions
Organisme : ecuphar italia srl
ID : IT0189/2018-PRVPRO-IP00
Informations de copyright
© 2021. The Author(s).
Références
Parasitology. 2017 Jan;144(1):95-115
pubmed: 27094260
Comp Immunol Microbiol Infect Dis. 2008 Nov;31(6):527-36
pubmed: 18262268
Parasit Vectors. 2020 Apr 15;13(1):193
pubmed: 32293524
Res Vet Sci. 2006 Aug;81(1):68-75
pubmed: 16288789
Parasit Vectors. 2018 Feb 21;11(1):103
pubmed: 29467015
Vet Immunol Immunopathol. 2012 Mar 15;146(1):97-9
pubmed: 22364963
Acta Trop. 2010 Dec;116(3):227-34
pubmed: 20816927
Int J Cancer. 2002 Feb 1;97(4):493-500
pubmed: 11802212
Vet J. 2021 May;271:105638
pubmed: 33840483
Mem Inst Oswaldo Cruz. 2018 Oct 18;113(11):e180301
pubmed: 30365645
Acta Med Austriaca Suppl. 2000;52:16-20
pubmed: 11261272
J Am Vet Med Assoc. 2010 Jun 1;236(11):1221-4
pubmed: 20513201
Res Vet Sci. 2019 Aug;125:218-226
pubmed: 31280121
Vet J. 2013 Oct;198(1):109-15
pubmed: 23899407
J Small Anim Pract. 2021 Jan;62(1):3
pubmed: 33169394
Life Sci. 1993;53(12):981-9
pubmed: 8361329
J Am Vet Med Assoc. 2010 Jun 1;236(11):1192-8
pubmed: 20513197
Acta Trop. 2012 Jun;122(3):291-5
pubmed: 22366671
J Vet Intern Med. 2018 Nov;32(6):1803-1822
pubmed: 30353952
Parasit Vectors. 2011 May 20;4:86
pubmed: 21599936
Vet J. 2009 Feb;179(2):259-63
pubmed: 18023375
Vet Parasitol. 2018 Nov 15;263:10-17
pubmed: 30389018
Vet Parasitol. 2019 Oct;274:108921
pubmed: 31536867
Trends Parasitol. 2002 Sep;18(9):399-405
pubmed: 12377257
Front Immunol. 2014 Jun 13;5:272
pubmed: 24982655
Ann Pharmacother. 1999 Apr;33(4):429-40
pubmed: 10332535
J Vet Intern Med. 2013 Nov-Dec;27 Suppl 1:S55-9
pubmed: 24635381
Am J Physiol. 1990 Nov;259(5 Pt 2):F793-800
pubmed: 1978572
J Am Vet Med Assoc. 2010 Jun 1;236(11):1184-91
pubmed: 20513195
Vet Clin Pathol. 2016 Dec;45(4):552-578
pubmed: 27805725
Cell Immunol. 1998 Mar 15;184(2):85-91
pubmed: 9630834
J Vet Intern Med. 2004 Sep-Oct;18(5):618-24
pubmed: 15515575
Am J Vet Res. 2003 May;64(5):558-61
pubmed: 12755294
Vet Parasitol. 2015 Feb 28;208(1-2):35-47
pubmed: 25573248
Biomed Res Int. 2018 Mar 29;2018:3296893
pubmed: 29789784
Am J Physiol. 1992 Jun;262(6 Pt 2):F932-8
pubmed: 1352430
Vet Clin Pathol. 2020 Dec;49(4):618-623
pubmed: 33341970
Vet Parasitol. 2017 May 30;239:50-56
pubmed: 28495197
Front Vet Sci. 2020 May 19;7:273
pubmed: 32509808
Front Cell Infect Microbiol. 2019 Dec 18;9:427
pubmed: 31921703
Ann N Y Acad Sci. 2000;917:248-57
pubmed: 11268351
Zentralbl Veterinarmed B. 1996 Oct;43(8):469-74
pubmed: 8921735
Parasit Vectors. 2011 Apr 13;4:48
pubmed: 21489234
Vet Parasitol. 2002 Jul 2;106(4):315-24
pubmed: 12079737
J Vet Intern Med. 2013 Nov-Dec;27 Suppl 1:S60-6
pubmed: 24635382