Endocervical Regulatory T Cells Are Associated With Decreased Genital Inflammation and Lower HIV Target Cell Abundance.
HIV
female genital tract
inflammation
regulatory T cells
vaginal microbiota
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2021
2021
Historique:
received:
16
06
2021
accepted:
06
09
2021
entrez:
11
10
2021
pubmed:
12
10
2021
medline:
27
11
2021
Statut:
epublish
Résumé
Regulatory T cells (Tregs) play important roles in tissue homeostasis, but few studies have investigated tissue Tregs in the context of genital inflammation, HIV target cell density, and vaginal microbiota in humans. In women from Nairobi (n=64), the proportion of CD4+ CD25+ CD127
Identifiants
pubmed: 34630402
doi: 10.3389/fimmu.2021.726472
pmc: PMC8495419
doi:
Substances chimiques
CTLA-4 Antigen
0
CTLA4 protein, human
0
Cytokines
0
FOXP3 protein, human
0
Forkhead Transcription Factors
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
726472Subventions
Organisme : CIHR
ID : PJT-148796
Pays : Canada
Informations de copyright
Copyright © 2021 Ssemaganda, Cholette, Perner, Kambaran, Adhiambo, Wambugu, Gebrebrhan, Lee, Nuhu, Mwatelah, Jahan, Omole, Wanjiru, Gitau, Kimani and McKinnon.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
APMIS. 2016 Aug;124(8):697-710
pubmed: 27245496
Annu Rev Immunol. 2020 Apr 26;38:541-566
pubmed: 32017635
Clin Infect Dis. 2015 Jul 15;61(2):260-9
pubmed: 25900168
JCI Insight. 2017 Aug 3;2(15):
pubmed: 28768913
Sci Transl Med. 2020 Nov 11;12(569):
pubmed: 33177180
Front Immunol. 2013 Jun 19;4:152
pubmed: 23801990
Mol Biol Cell. 2015 Aug 1;26(15):2845-57
pubmed: 26063731
Sci Immunol. 2018 Jul 6;3(25):
pubmed: 29980618
Mucosal Immunol. 2016 Jan;9(1):194-205
pubmed: 26104913
J Infect Dis. 2006 Jun 1;193(11):1478-86
pubmed: 16652274
BMC Infect Dis. 2011 Jan 11;11:10
pubmed: 21223574
Int J Dev Biol. 2014;58(2-4):205-17
pubmed: 25023687
Sex Transm Infect. 2014 Dec;90(8):580-7
pubmed: 25107710
Curr HIV/AIDS Rep. 2015 Jun;12(2):216-22
pubmed: 25877253
J Reprod Immunol. 2012 Dec;96(1-2):1-7
pubmed: 23021867
PLoS One. 2017 Jun 1;12(6):e0178193
pubmed: 28570576
Annu Rev Immunol. 2016 May 20;34:609-33
pubmed: 27168246
Nat Med. 2019 Jun;25(6):1012-1021
pubmed: 31142849
Infect Immun. 2008 Dec;76(12):5456-65
pubmed: 18824531
J Immunol. 2011 Dec 1;187(11):6032-42
pubmed: 22048765
J Acquir Immune Defic Syndr. 2020 Sep 1;85(1):79-87
pubmed: 32433252
Sci Rep. 2017 Sep 11;7(1):11123
pubmed: 28894259
Nat Rev Immunol. 2009 Dec;9(12):883-9
pubmed: 19935807
Nat Commun. 2019 Nov 19;10(1):5227
pubmed: 31745084
AIDS. 2008 Jul 31;22(12):1493-501
pubmed: 18614873
Clin Infect Dis. 2003 Aug 1;37(3):319-25
pubmed: 12884154
Front Immunol. 2018 Apr 25;9:883
pubmed: 29887862
BJOG. 2006 Dec;113(12):1419-25
pubmed: 17010117
Nat Med. 2018 May;24(4):491-496
pubmed: 29480895
J Acquir Immune Defic Syndr. 2015 Jan 1;68(1):6-12
pubmed: 25296095
Mucosal Immunol. 2016 Nov;9(6):1395-1406
pubmed: 27007674
Am J Obstet Gynecol. 2000 Sep;183(3):738-45
pubmed: 10992202
J Reprod Immunol. 2017 Apr;120:48-55
pubmed: 28463710
Ann Epidemiol. 2012 Mar;22(3):213-20
pubmed: 22192490
Curr Opin HIV AIDS. 2012 Mar;7(2):195-202
pubmed: 22314505
Cell Host Microbe. 2016 Apr 13;19(4):529-40
pubmed: 27078070
J Immunol. 1995 Aug 1;155(3):1151-64
pubmed: 7636184
J Infect Dis. 2016 Jul 1;214(1):23-31
pubmed: 27117511
Front Immunol. 2015 Aug 03;6:395
pubmed: 26284077
PLoS Pathog. 2016 Sep 22;12(9):e1005889
pubmed: 27656899
Mucosal Immunol. 2014 Nov;7(6):1375-85
pubmed: 24759207
Cell Rep. 2019 May 28;27(9):2537-2547.e5
pubmed: 31141680
Best Pract Res Clin Obstet Gynaecol. 2007 Jun;21(3):375-90
pubmed: 17241817
Nat Immunol. 2019 Apr;20(4):471-481
pubmed: 30778241