Genetic and Environmental Determinants of T Helper 17 Pathogenicity in Spondyloarthropathies.
Spondyloarthropathies
T helper 17 cell
ankylosing spondylitis
genetic risk
genome-wide association studies
interleukin 17
pathogenicity
Journal
Frontiers in genetics
ISSN: 1664-8021
Titre abrégé: Front Genet
Pays: Switzerland
ID NLM: 101560621
Informations de publication
Date de publication:
2021
2021
Historique:
received:
30
04
2021
accepted:
24
08
2021
entrez:
11
10
2021
pubmed:
12
10
2021
medline:
12
10
2021
Statut:
epublish
Résumé
In Spondyloarthropathies (SpA), a common group of immune-mediated diseases characterised by excessive inflammation of musculo-skeletal structures and extra-articular organs, T helper 17 (Th17) cells are widely considered the main drivers of the disease. Th17 are able to modulate their genes according to the immune environment: upon differentiation, they can adopt either housekeeping, anti-bacterial gene modules or inflammatory, pathogenic functions, and only the latter would mediate immune diseases, such as SpA. Experimental work aimed at characterising Th17 heterogeneity is largely performed on murine cells, for which the
Identifiants
pubmed: 34630512
doi: 10.3389/fgene.2021.703242
pmc: PMC8492997
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
703242Informations de copyright
Copyright © 2021 Simone, Stingo and Ciccia.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The handling editor declared a past co-authorship with one of the authors FC.
Références
Ann Rheum Dis. 2016 Dec;75(12):2150-2156
pubmed: 26916345
Nat Immunol. 2011 Mar;12(3):255-63
pubmed: 21278737
Immunity. 2015 Oct 20;43(4):727-38
pubmed: 26431948
Immunity. 2019 Jul 16;51(1):77-89.e6
pubmed: 31229354
Immunity. 2010 Aug 27;33(2):279-88
pubmed: 20732640
Nat Immunol. 2007 Sep;8(9):942-9
pubmed: 17676045
Inflamm Bowel Dis. 2014 Mar;20(3):587-95
pubmed: 24481050
Nature. 2015 Jul 9;523(7559):221-5
pubmed: 25924064
Ann Rheum Dis. 2019 Mar;78(3):350-354
pubmed: 30626658
Trends Genet. 2013 Feb;29(2):74-83
pubmed: 23122694
Nature. 2006 May 11;441(7090):235-8
pubmed: 16648838
Cell. 2012 Oct 12;151(2):289-303
pubmed: 23021777
Immunity. 2006 Feb;24(2):179-89
pubmed: 16473830
Arthritis Rheum. 2009 Jun;60(6):1647-56
pubmed: 19479869
Nat Immunol. 2012 Oct;13(10):991-9
pubmed: 22961052
J Clin Invest. 2020 Apr 1;130(4):1863-1878
pubmed: 32149730
J Immunol. 2012 Oct 1;189(7):3285-91
pubmed: 22997231
Nat Commun. 2017 Nov 15;8(1):1510
pubmed: 29142230
J Biol Chem. 2007 Mar 30;282(13):9358-9363
pubmed: 17277312
Proc Natl Acad Sci U S A. 2010 Aug 17;107(33):14751-6
pubmed: 20679229
Ann Rheum Dis. 2020 May;79(5):595-604
pubmed: 32253184
Immunity. 2021 Apr 13;54(4):673-686.e4
pubmed: 33852831
Nat Genet. 2011 Mar;43(3):246-52
pubmed: 21297633
Nat Genet. 2007 Nov;39(11):1329-37
pubmed: 17952073
Nat Med. 2007 Oct;13(10):1173-5
pubmed: 17828272
Immunity. 2009 Jan 16;30(1):92-107
pubmed: 19119024
J Exp Med. 2005 Jan 17;201(2):233-40
pubmed: 15657292
Nat Immunol. 2007 Sep;8(9):967-74
pubmed: 17581537
Nat Immunol. 2003 Apr;4(4):330-6
pubmed: 12612578
Nat Immunol. 2007 Dec;8(12):1390-7
pubmed: 17994024
PLoS One. 2011 Feb 22;6(2):e17160
pubmed: 21364948
J Invest Dermatol. 2013 Oct;133(10):2381-2389
pubmed: 23563201
Arthritis Rheum. 2009 Apr;60(4):955-65
pubmed: 19333939
Nat Immunol. 2007 Sep;8(9):958-66
pubmed: 17676043
Nat Immunol. 2008 Jun;9(6):650-7
pubmed: 18454150
PLoS Genet. 2010 Dec 02;6(12):e1001195
pubmed: 21152001
Nature. 2003 Feb 13;421(6924):744-8
pubmed: 12610626
J Biol Chem. 2003 Jan 17;278(3):1910-4
pubmed: 12417590
Nat Genet. 2013 Jul;45(7):730-8
pubmed: 23749187
Nat Immunol. 2008 Jun;9(6):641-9
pubmed: 18454151
Cell. 2015 Dec 3;163(6):1400-12
pubmed: 26607794
Curr Opin Rheumatol. 2019 Jan;31(1):62-69
pubmed: 30407224
Cell Rep. 2017 May 30;19(9):1888-1901
pubmed: 28564606
Nature. 2006 May 11;441(7090):231-4
pubmed: 16648837
Nat Immunol. 2011 Jun;12(6):568-75
pubmed: 21516111
Cell. 2015 Dec 3;163(6):1413-27
pubmed: 26607793
Cell. 1997 May 16;89(4):587-96
pubmed: 9160750
Lancet. 2018 Dec 8;392(10163):2441-2451
pubmed: 30360964
Ann Rheum Dis. 2014 Aug;73(8):1566-74
pubmed: 23740229
Nature. 2018 Feb 15;554(7692):373-377
pubmed: 29414937
Nature. 2009 Jul 16;460(7253):405-9
pubmed: 19578362
Ann Rheum Dis. 2018 Sep;77(9):1295-1302
pubmed: 29945918
Cell Rep. 2016 Jul 12;16(2):392-404
pubmed: 27346359
Nat Immunol. 2018 Jul;19(7):755-765
pubmed: 29915298
Immunity. 2009 Apr 17;30(4):576-87
pubmed: 19362022
Nat Rev Rheumatol. 2018 Aug;14(8):453-466
pubmed: 30006601
Cell. 2019 Mar 7;176(6):1340-1355.e15
pubmed: 30799037
Sci Rep. 2018 Oct 23;8(1):15645
pubmed: 30353145
Immunity. 2019 Apr 16;50(4):892-906
pubmed: 30995505
Nat Immunol. 2009 Mar;10(3):314-24
pubmed: 19182808
Cell. 2000 Mar 17;100(6):655-69
pubmed: 10761931
J Exp Med. 2016 Oct 17;213(11):2489-2501
pubmed: 27670590
Rheumatology (Oxford). 2018 Aug 1;57(suppl_6):vi4-vi9
pubmed: 30445483
Cell. 2009 Oct 30;139(3):485-98
pubmed: 19836068
Nature. 2010 Oct 21;467(7318):967-71
pubmed: 20962846
Nat Immunol. 2005 Nov;6(11):1123-32
pubmed: 16200070
Nature. 2012 Apr 26;484(7395):514-8
pubmed: 22466287