Natural Antibodies and Alloreactive T Cells Long after Kidney Transplantation.
Journal
Journal of transplantation
ISSN: 2090-0007
Titre abrégé: J Transplant
Pays: United States
ID NLM: 101519118
Informations de publication
Date de publication:
2021
2021
Historique:
received:
24
04
2021
revised:
01
09
2021
accepted:
21
09
2021
entrez:
11
10
2021
pubmed:
12
10
2021
medline:
12
10
2021
Statut:
epublish
Résumé
The relationship between circulating effector memory T and B cells long after transplantation and their susceptibility to immunosuppression are unknown. To investigate the impact of antirejection therapy on T cell-B cell coordinated immune responses, we assessed IFN- Plasma levels of IgG nAbs to malondialdehyde (MDA) were measured in 145 kidney transplant recipients at 5-7 years after transplantation. In 54 of these patients, the number of donor-reactive IFN- The number of donor-reactive IFN- The positive correlation found between alloreactive T cells and nAbs in rejectors suggests an intricate role for both components of the immune response in the rejection process. Treatment with intravenous immune globulin impacted nAbs.
Sections du résumé
BACKGROUND
BACKGROUND
The relationship between circulating effector memory T and B cells long after transplantation and their susceptibility to immunosuppression are unknown. To investigate the impact of antirejection therapy on T cell-B cell coordinated immune responses, we assessed IFN-
METHODS
METHODS
Plasma levels of IgG nAbs to malondialdehyde (MDA) were measured in 145 kidney transplant recipients at 5-7 years after transplantation. In 54 of these patients, the number of donor-reactive IFN-
RESULTS
RESULTS
The number of donor-reactive IFN-
CONCLUSION
CONCLUSIONS
The positive correlation found between alloreactive T cells and nAbs in rejectors suggests an intricate role for both components of the immune response in the rejection process. Treatment with intravenous immune globulin impacted nAbs.
Identifiants
pubmed: 34631160
doi: 10.1155/2021/7005080
pmc: PMC8497134
doi:
Types de publication
Journal Article
Langues
eng
Pagination
7005080Subventions
Organisme : NIAID NIH HHS
ID : R01 AI123342
Pays : United States
Informations de copyright
Copyright © 2021 Nicole M. van Besouw et al.
Déclaration de conflit d'intérêts
The authors declare no conflicts of interest.
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