Is there a place for cellular therapy in depression?
Depression
Immunomodulation
Inflammation
Mesenchymal stem-cells transplant
Mood disorders
Stem cells transplant
Journal
World journal of psychiatry
ISSN: 2220-3206
Titre abrégé: World J Psychiatry
Pays: United States
ID NLM: 101610480
Informations de publication
Date de publication:
19 Sep 2021
19 Sep 2021
Historique:
received:
28
02
2021
revised:
05
05
2021
accepted:
13
08
2021
entrez:
11
10
2021
pubmed:
12
10
2021
medline:
12
10
2021
Statut:
epublish
Résumé
Although efforts have been made to improve the pharmacological treatment of depression, approximately one-third of patients with depression do not respond to conventional therapy using antidepressants. Other potential non-pharmacological therapies have been studied in the last years, including the use of mesenchymal stem cell therapies to treat depression. These therapies are reviewed here since it is clinically relevant to develop innovative therapeutics to treat psychiatric patients. Experimental data corroborate that mesenchymal stem cell therapy could be considered a potential treatment for depression based on its anti-inflammatory and neurotrophic properties. However, some clinical trials involving treatment of depression with stem cells are in progress, but with no published results. These studies and other future clinical investigations will be crucial to define how much mesenchymal stem cells can effectively be used in psychiatric clinics as a strategy for supporting depression treatment.
Identifiants
pubmed: 34631460
doi: 10.5498/wjp.v11.i9.553
pmc: PMC8474995
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
553-567Informations de copyright
©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
Déclaration de conflit d'intérêts
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
Références
J Neuroinflammation. 2011 Aug 10;8:94
pubmed: 21831269
Mol Psychiatry. 2018 Feb;23(2):335-343
pubmed: 27752078
Nat Neurosci. 2002 May;5(5):405-14
pubmed: 11953750
J Affect Disord. 2019 Mar 1;246:42-51
pubmed: 30578945
Lancet. 2018 Nov 24;392(10161):2299-2312
pubmed: 30396512
Brain Behav Immun. 2018 Aug;72:2-13
pubmed: 29102801
J Natl Cancer Inst. 1951 Aug;12(1):197-201
pubmed: 14874130
Lancet. 2015 Aug 22;386(9995):743-800
pubmed: 26063472
J Affect Disord. 2018 Jun;233:45-67
pubmed: 29150144
J Clin Psychiatry. 2018 Dec 4;80(1):
pubmed: 30549489
Am J Respir Cell Mol Biol. 2005 Aug;33(2):145-52
pubmed: 15891110
Epilepsia. 2016 Sep;57(9):1354-62
pubmed: 27374986
Int Immunopharmacol. 2020 Feb 20;82:106285
pubmed: 32088640
Mol Psychiatry. 2020 Jun;25(6):1202-1214
pubmed: 30108315
Nat Rev Neurol. 2011 Jan;7(1):31-40
pubmed: 21135885
Psychiatr Neurol (Basel). 1957 Jan-Feb;133(1-2):1-17
pubmed: 13420229
Pharmacol Rep. 2021 Feb;73(1):31-42
pubmed: 33015736
F1000Res. 2018 Aug 14;7:
pubmed: 30135724
Prog Neuropsychopharmacol Biol Psychiatry. 2011 Apr 29;35(3):702-21
pubmed: 21185346
Acta Pharmacol Sin. 2020 May;41(5):612-619
pubmed: 31796867
Neuron. 2020 Jul 22;107(2):234-256
pubmed: 32553197
Psychiatr Pol. 2018 Jun 30;52(3):437-447
pubmed: 30218560
Gene Ther. 2018 Dec;25(8):538-547
pubmed: 30254305
Psychoneuroendocrinology. 2019 Jul;105:164-171
pubmed: 30826163
Blood. 2005 Sep 1;106(5):1755-61
pubmed: 15905186
Adv Exp Med Biol. 2019;1084:145-174
pubmed: 30039439
Biochem Biophys Res Commun. 2014 Apr 18;446(4):983-9
pubmed: 24657442
Proc Natl Acad Sci U S A. 2010 Aug 17;107(33):14817-22
pubmed: 20679216
Nature. 2010 Aug 12;466(7308):829-34
pubmed: 20703299
J Cell Physiol. 2018 Apr;233(4):2815-2823
pubmed: 28475219
Seizure. 2010 Mar;19(2):84-92
pubmed: 20080419
Immunol Cell Biol. 2013 Jan;91(1):40-51
pubmed: 23207278
Brain Res Bull. 2020 Oct;163:109-119
pubmed: 32681971
J Tissue Eng Regen Med. 2019 Sep;13(9):1738-1755
pubmed: 31216380
J Neurosci. 2015 Jun 3;35(22):8411-22
pubmed: 26041910
Front Cell Dev Biol. 2020 Feb 21;8:107
pubmed: 32154253
CNS Neurosci Ther. 2015 May;21(5):463-71
pubmed: 25645708
Nat Med. 2016 Mar;22(3):238-49
pubmed: 26937618
Annu Rev Public Health. 2013;34:119-38
pubmed: 23514317
J Med Life. 2016 Apr-Jun;9(2):120-5
pubmed: 27453739
Blood Rev. 1996 Dec;10(4):215-9
pubmed: 9012918
Acta Neuropsychiatr. 2018 Feb;30(1):1-16
pubmed: 28112061
J Psychopharmacol. 2019 May;33(5):632-639
pubmed: 31018809
Biol Psychiatry. 2010 Oct 15;68(8):748-54
pubmed: 20719303
Public Health. 2017 Aug;149:138-148
pubmed: 28641155
Scand J Immunol. 2010 Sep;72(3):242-9
pubmed: 20696022
Metabolism. 2019 Jan;90:1-15
pubmed: 30342065
BMC Med. 2011 Jul 26;9:90
pubmed: 21791035
Prog Neuropsychopharmacol Biol Psychiatry. 2012 Oct 1;39(1):112-9
pubmed: 22664354
Nat Rev Immunol. 2016 Jan;16(1):22-34
pubmed: 26711676
Eur Psychiatry. 2015 Sep;30(6):665-80
pubmed: 26078093
Neurochem Res. 2014 Feb;39(2):259-68
pubmed: 24343530
Trends Cardiovasc Med. 2020 Apr;30(3):170-176
pubmed: 31109802
Aging (Albany NY). 2020 Feb 24;12(4):3880-3898
pubmed: 32096479
J Cell Biochem. 2011 Oct;112(10):2683-7
pubmed: 21678464
Arch Gen Psychiatry. 2012 Oct;69(10):1044-53
pubmed: 23026954
Brain Behav Immun. 2015 Jan;43:46-53
pubmed: 25016200
Cells. 2019 Feb 02;8(2):
pubmed: 30717429
Front Immunol. 2019 Apr 16;10:798
pubmed: 31040848
Stem Cell Investig. 2016 Sep 19;3:48
pubmed: 27777937
Stem Cells. 2009 Jun;27(6):1421-32
pubmed: 19489103
Brain Behav Immun. 2020 Aug;88:132-143
pubmed: 32553784
Biol Psychiatry. 2009 Sep 1;66(5):407-14
pubmed: 19423079
Cytotechnology. 2014 Mar;66(2):193-9
pubmed: 23929461
Mol Psychiatry. 2020 Feb;25(2):339-350
pubmed: 31427752
World J Stem Cells. 2020 Feb 26;12(2):100-109
pubmed: 32184935
Regen Med. 2019 Mar;14(3):213-230
pubmed: 30762487
PLoS Genet. 2011 Nov;7(11):e1002355
pubmed: 22072984
Mol Ther. 2015 May;23(5):812-823
pubmed: 25868399
PM R. 2015 Apr;7(4 Suppl):S8-S18
pubmed: 25864664
Br Med J. 1956 Sep 15;2(4993):626-7
pubmed: 13356034
Curr Opin Neurobiol. 2015 Feb;30:24-30
pubmed: 25218233
J Affect Disord. 2020 Mar 15;265:247-254
pubmed: 32090748
Curr Neuropharmacol. 2018;16(5):533-558
pubmed: 29173175
Nat Med. 2009 Jan;15(1):42-9
pubmed: 19098906
Mol Psychiatry. 2016 May;21(5):642-9
pubmed: 26033244
Adv Clin Exp Med. 2018 Jul;27(7):873-880
pubmed: 29905411
Lancet. 1968 Jun 22;1(7556):1373-4
pubmed: 4172674
Neuropsychopharmacology. 2021 Apr;46(5):939-948
pubmed: 33504955
J Neuroinflammation. 2020 Apr 22;17(1):126
pubmed: 32321532
Am J Psychiatry. 2006 Nov;163(11):1905-17
pubmed: 17074942
Sci Rep. 2019 Dec 27;9(1):19999
pubmed: 31882820
Life Sci. 2020 Apr 1;246:117405
pubmed: 32035129
Curr Neuropharmacol. 2018 Jan 30;16(2):176-209
pubmed: 28847294
Stem Cells Transl Med. 2014 Oct;3(10):1220-30
pubmed: 25122689
Int J Stem Cells. 2016 May 30;9(1):90-5
pubmed: 27426090
Schweiz Med Wochenschr. 1957 Aug 31;87(35-36):1135-40
pubmed: 13467194
Brain Behav Immun. 2013 Jan;27(1):1-7
pubmed: 22964544
Neuropsychopharmacology. 2017 Jan;42(1):36-45
pubmed: 27412959
Acta Psychiatr Scand. 2017 May;135(5):373-387
pubmed: 28122130
Stem Cells Dev. 2011 Aug;20(8):1297-308
pubmed: 21303266
Front Pharmacol. 2019 May 21;10:452
pubmed: 31164818
J Neurosci. 2009 Feb 18;29(7):2089-102
pubmed: 19228962
N Engl J Med. 1957 Sep 12;257(11):491-6
pubmed: 13464965