Evaluation of the skin phototoxicity of systemically administered pharmaceuticals in Sprague-Dawley rats.
Histopathological finding
In vivo test
Phototoxicity
Skin reaction
UVA
Journal
Toxicological research
ISSN: 1976-8257
Titre abrégé: Toxicol Res
Pays: Singapore
ID NLM: 101483324
Informations de publication
Date de publication:
Oct 2021
Oct 2021
Historique:
received:
13
08
2020
revised:
13
11
2020
accepted:
04
12
2020
entrez:
11
10
2021
pubmed:
12
10
2021
medline:
12
10
2021
Statut:
epublish
Résumé
In vivo phototoxicity testing is important for predicting drug-induced phototoxicity in humans. Currently, there is no internationally validated in vivo test method for the photosafety evaluation of pharmaceuticals. In this study, we evaluated the phototoxicity of systemically administered drugs using SD rats. We first determined the appropriate ultraviolet A (UVA) dose using 8-methoxypsoralen, a well-known phototoxic drug. Compared to lower and higher UVA doses, we found that a UVA dose of 10 J/cm
Identifiants
pubmed: 34631500
doi: 10.1007/s43188-020-00078-7
pii: 78
pmc: PMC8476693
doi:
Types de publication
Journal Article
Langues
eng
Pagination
435-442Informations de copyright
© Korean Society of Toxicology 2021.
Déclaration de conflit d'intérêts
Conflict of interestNone declared.
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