Design and Synthesis of New Quinoxaline Derivatives as Potential Histone Deacetylase Inhibitors Targeting Hepatocellular Carcinoma:
HDAC
anti-proliferative
apoptosis
molecular modeling
quinoxaline
structure-activity relationship
Journal
Frontiers in chemistry
ISSN: 2296-2646
Titre abrégé: Front Chem
Pays: Switzerland
ID NLM: 101627988
Informations de publication
Date de publication:
2021
2021
Historique:
received:
15
06
2021
accepted:
29
07
2021
entrez:
11
10
2021
pubmed:
12
10
2021
medline:
12
10
2021
Statut:
epublish
Résumé
Guided by the structural optimization principle and the promising anticancer effect of the quinoxaline nucleus, a new series of novel HDAC inhibitors were designed and synthesized. The synthesized compounds were designed to bear the reported pharmacophoric features of the HDAC inhibitors in addition to an extra moiety to occupy the non-used vacant deep pocket of the HDAC receptor. The newly prepared compounds were evaluated for their
Identifiants
pubmed: 34631658
doi: 10.3389/fchem.2021.725135
pii: 725135
pmc: PMC8493129
doi:
Types de publication
Journal Article
Langues
eng
Pagination
725135Informations de copyright
Copyright © 2021 Ma, Taghour, Belal, Mehany, Mostafa, Nabeeh, Eissa and Al-Karmalawy.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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