Amnion-Derived Mesenchymal Stromal/Stem Cell Paracrine Signals Potentiate Human Liver Organoid Differentiation: Translational Implications for Liver Regeneration.
3D liver organoid culture
hepatic progenitor cell differentiation
hepatocyte culture
human amnion-derived mesenchymal stem cells
liver regeneration
Journal
Frontiers in medicine
ISSN: 2296-858X
Titre abrégé: Front Med (Lausanne)
Pays: Switzerland
ID NLM: 101648047
Informations de publication
Date de publication:
2021
2021
Historique:
received:
23
07
2021
accepted:
30
08
2021
entrez:
11
10
2021
pubmed:
12
10
2021
medline:
12
10
2021
Statut:
epublish
Résumé
The prevalence of end-stage liver diseases has reached very high levels globally. The election treatment for affected patients is orthotopic liver transplantation, which is a very complex procedure, and due to the limited number of suitable organ donors, considerable research is being done on alternative therapeutic options. For instance, the use of cell therapy, such as the transplantation of hepatocytes to promote liver repair/regeneration, has been explored, but standardized protocols to produce suitable human hepatocytes are still limited. On the other hand, liver progenitor and multipotent stem cells offer potential cell sources that could be used clinically. Different studies have reported regarding the therapeutic effects of transplanted mesenchymal stromal/stem cells (MSCs) on end-stage liver diseases. Moreover, it has been shown that delivery of MSC-derived conditioned medium (MSC-CM) can reduce cell death and enhance liver proliferation in fulminant hepatic failure. Therefore, it is believed that MSC-CM contains many factors that probably support liver regeneration. In our work, we used an
Identifiants
pubmed: 34631757
doi: 10.3389/fmed.2021.746298
pmc: PMC8494784
doi:
Types de publication
Journal Article
Langues
eng
Pagination
746298Informations de copyright
Copyright © 2021 Lo Nigro, Gallo, Bulati, Vitale, Paini, Pampalone, Galvagno, Conaldi and Miceli.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Cell. 2015 Jan 15;160(1-2):299-312
pubmed: 25533785
Eur J Gastroenterol Hepatol. 2009 Oct;21(10):1199-205
pubmed: 19455046
Cell Stem Cell. 2019 Jul 3;25(1):39-53.e10
pubmed: 31080135
Stem Cell Rev Rep. 2020 Oct;16(5):853-875
pubmed: 32681232
Mol Med Rep. 2017 Dec;16(6):7879-7889
pubmed: 28983598
Emerg Microbes Infect. 2019;8(1):879-894
pubmed: 31179847
J Hepatol. 2016 May;64(5):1068-1075
pubmed: 26778754
Hepatology. 2020 Aug;72(2):584-594
pubmed: 31773739
Methods Mol Biol. 2018;1706:17-38
pubmed: 29423791
Stem Cells Int. 2019 Feb 18;2019:7486279
pubmed: 30911299
Nature. 2013 Feb 14;494(7436):247-50
pubmed: 23354049
Ann Surg. 2017 Sep;266(3):441-449
pubmed: 28657945
Science. 2001 Oct 19;294(5542):559-63
pubmed: 11577199
PLoS One. 2007 Sep 26;2(9):e941
pubmed: 17895982
Am J Physiol Gastrointest Liver Physiol. 2016 Aug 1;311(2):G203-9
pubmed: 27313175
Hepatology. 2011 Oct;54(4):1445-53
pubmed: 21626524
Lab Invest. 1996 Jul;75(1):15-24
pubmed: 8683936
J Hepatol. 2017 May;66(5):987-1000
pubmed: 28027971
Cell. 2016 Jun 16;165(7):1586-1597
pubmed: 27315476
Stem Cells. 2017 Apr;35(4):851-858
pubmed: 28294454
Tissue Eng Regen Med. 2019 Feb 21;16(2):107-118
pubmed: 30989038
Cell Mol Life Sci. 2018 Apr;75(8):1307-1324
pubmed: 29181772
Pediatr Res. 2018 Jan;83(1-2):232-240
pubmed: 29149103
Regen Med. 2009 Mar;4(2):275-91
pubmed: 19317646
Ann N Y Acad Sci. 2006 Nov;1089:262-7
pubmed: 17261773
Nat Rev Genet. 2008 May;9(5):329-40
pubmed: 18398419
Proc Natl Acad Sci U S A. 2011 Jul 12;108(28):11452-7
pubmed: 21693646
Stem Cells Dev. 2019 Nov 1;28(21):1451-1462
pubmed: 31495270
Nat Rev Mol Cell Biol. 2004 Oct;5(10):836-47
pubmed: 15459664
World J Gastroenterol. 2004 Feb 1;10(3):385-8
pubmed: 14760763
Lancet Gastroenterol Hepatol. 2020 Mar;5(3):245-266
pubmed: 31981519
J Hepatol. 2015 Apr;62(1 Suppl):S157-69
pubmed: 25920085
Exp Hematol Oncol. 2018 Dec 5;7:30
pubmed: 30534474
Stem Cells Int. 2012;2012:530674
pubmed: 23251189
Transplantation. 2021 Apr 1;105(4):824-831
pubmed: 32433235
Gastroenterology. 2016 May;150(5):1098-1112
pubmed: 26774180
Int J Mol Sci. 2021 Jan 06;22(2):
pubmed: 33419219
Front Immunol. 2020 Feb 12;11:54
pubmed: 32117234
Development. 2017 Mar 15;144(6):958-962
pubmed: 28292841
Science. 1996 Nov 22;274(5291):1379-83
pubmed: 8910279
J Gastroenterol. 2019 Sep;54(9):763-773
pubmed: 31270691
Int J Mol Sci. 2018 Nov 22;19(12):
pubmed: 30469540
J Cell Mol Med. 2015 Mar;19(3):511-20
pubmed: 25534251
Int J Mol Sci. 2021 Jan 14;22(2):
pubmed: 33466583
Can J Gastroenterol Hepatol. 2018 Jul 2;2018:2593745
pubmed: 30065914
PLoS One. 2014 Apr 24;9(4):e96053
pubmed: 24763697
Biomedicines. 2016 Jan 06;4(1):
pubmed: 28536370
Biochem Biophys Res Commun. 2020 Jan 29;522(1):171-176
pubmed: 31757423
Hepatobiliary Surg Nutr. 2013 Apr;2(2):68-77
pubmed: 24570919
Stem Cells Int. 2018 Jul 12;2018:9156560
pubmed: 30123296
Stem Cell Res. 2010 Jul;5(1):4-22
pubmed: 20483202
FASEB J. 1999 Sep;13(12):1565-74
pubmed: 10463948
EMBO J. 2015 Apr 15;34(8):987-1008
pubmed: 25766254
Cell Stem Cell. 2010 Jan 8;6(1):25-36
pubmed: 20085740
J Surg Res. 2013 Aug;183(2):907-15
pubmed: 23522455