Intranasal vaccination with a Newcastle disease virus-vectored vaccine protects hamsters from SARS-CoV-2 infection and disease.
Immune respons
Virology
Journal
iScience
ISSN: 2589-0042
Titre abrégé: iScience
Pays: United States
ID NLM: 101724038
Informations de publication
Date de publication:
19 Nov 2021
19 Nov 2021
Historique:
received:
07
05
2021
revised:
24
08
2021
accepted:
30
09
2021
pubmed:
12
10
2021
medline:
12
10
2021
entrez:
11
10
2021
Statut:
ppublish
Résumé
The pandemic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of coronavirus disease 2019 (COVID-19). Worldwide efforts are being made to develop vaccines to mitigate this pandemic. We engineered two recombinant Newcastle disease virus (NDV) vectors expressing either the full-length SARS-CoV-2 spike protein (NDV-FLS) or a version with a 19 amino acid deletion at the carboxy terminus (NDV-Δ19S). Hamsters receiving two doses (prime-boost) of NDV-FLS developed a robust SARS-CoV-2-neutralizing antibody response, with elimination of infectious virus in the lungs and minimal lung pathology at five days post-challenge. Single-dose vaccination with NDV-FLS significantly reduced SARS-CoV-2 replication in the lungs but only mildly decreased lung inflammation. NDV-Δ19S-treated hamsters had a moderate decrease in SARS-CoV-2 titers in lungs and presented with severe microscopic lesions, suggesting that truncation of the spike protein was a less effective strategy. In summary, NDV-vectored vaccines represent a viable option for protection against COVID-19.
Identifiants
pubmed: 34632328
doi: 10.1016/j.isci.2021.103219
pii: S2589-0042(21)01187-1
pmc: PMC8492382
doi:
Types de publication
Journal Article
Langues
eng
Pagination
103219Commentaires et corrections
Type : CommentIn
Informations de copyright
© 2021 The Author(s).
Déclaration de conflit d'intérêts
L.A.S., Y.P., B.W.B., P.P.M., L.S., and S.K.W. are co-inventors on a United States Provisional Application No. 63/196,489 entitled “ENGINEERED NEWCASTLE DISEASE VIRUS VECTOR AND USES THEREOF”, which was filed June 3, 2021.
Références
N Engl J Med. 2020 Mar 26;382(13):1199-1207
pubmed: 31995857
Proc Natl Acad Sci U S A. 2012 Aug 28;109(35):13996-4000
pubmed: 22891297
J Gen Virol. 2019 Dec;100(12):1593-1594
pubmed: 31609197
Lancet Infect Dis. 2020 Jun;20(6):669-677
pubmed: 32240634
Nat Rev Immunol. 2020 Oct;20(10):615-632
pubmed: 32887954
J Gen Virol. 2005 Aug;86(Pt 8):2269-2274
pubmed: 16033974
Eur J Clin Invest. 2021 May;51(5):e13554
pubmed: 33768536
Lancet. 2020 Feb 15;395(10223):514-523
pubmed: 31986261
Nature. 2020 Mar;579(7798):270-273
pubmed: 32015507
J Vet Diagn Invest. 2011 Jul;23(4):637-56
pubmed: 21908305
J Clin Oncol. 2002 May 1;20(9):2251-66
pubmed: 11980996
Lancet. 2020 Aug 1;396(10247):320-332
pubmed: 32682491
J Virol. 2008 Sep;82(18):9303
pubmed: 18755681
Lancet. 2020 Feb 22;395(10224):565-574
pubmed: 32007145
EBioMedicine. 2020 Dec;62:103132
pubmed: 33232870
J Virol. 2006 Nov;80(21):10652-62
pubmed: 17041223
Nature. 2020 Oct;586(7830):509-515
pubmed: 32967005
Infect Genet Evol. 2020 Oct;84:104493
pubmed: 32768565
Lancet. 2020 May 2;395(10234):1417-1418
pubmed: 32325026
Emerg Infect Dis. 2020 Sep;26(9):2005-2015
pubmed: 32437316
Nat Med. 2020 Apr;26(4):450-452
pubmed: 32284615
Mol Ther Methods Clin Dev. 2017 Oct 16;9:181-191
pubmed: 29556508
J Gen Virol. 2015 Jan;96(Pt 1):40-45
pubmed: 25274858
Clin Infect Dis. 2020 Dec 3;71(9):2428-2446
pubmed: 32215622
Pathogens. 2020 Jul 29;9(8):
pubmed: 32751194
Proc Natl Acad Sci U S A. 2006 May 23;103(21):8203-8
pubmed: 16717196
Vaccines (Basel). 2020 Dec 17;8(4):
pubmed: 33348607
Cell. 2020 May 28;181(5):1016-1035.e19
pubmed: 32413319
Curr Protoc Microbiol. 2006 Jun;Chapter 15:15F.2.1-15F.2.18
pubmed: 18770579
Immunity. 2016 Jun 21;44(6):1379-91
pubmed: 27287409
Virulence. 2021 Dec;12(1):507-508
pubmed: 33494661
Emerg Infect Dis. 2020 Aug;26(8):1926-1928
pubmed: 32396504
Virchows Arch. 2020 Sep;477(3):359-372
pubmed: 32642842
Nature. 2020 Jul;583(7818):834-838
pubmed: 32408338
Science. 2021 Jan 22;371(6527):329-330
pubmed: 33479129
Front Immunol. 2020 Oct 07;11:576622
pubmed: 33117378
Euro Surveill. 2020 Mar;25(12):
pubmed: 32234121
Mucosal Immunol. 2021 Mar;14(2):305-316
pubmed: 33244161
J Virol. 1998 Feb;72(2):891-9
pubmed: 9444980
Methods Mol Biol. 2020;2099:205-220
pubmed: 31883098
Proc Natl Acad Sci U S A. 2020 Jul 14;117(28):16587-16595
pubmed: 32571934
Nature. 2020 Aug;584(7821):430-436
pubmed: 32640463
Front Immunol. 2019 Jul 17;10:1605
pubmed: 31379823
New Microbes New Infect. 2021 Sep;43:100929
pubmed: 34336227
J Biol Chem. 2021 Jan-Jun;296:100111
pubmed: 33229438
Am J Respir Cell Mol Biol. 2020 Dec;63(6):856-859
pubmed: 32897757
Int J Lab Hematol. 2020 Jun;42 Suppl 1:11-18
pubmed: 32311826
J Virol Methods. 2014 Jun;202:28-33
pubmed: 24626064
J Virol. 2005 Nov;79(21):13275-84
pubmed: 16227250
Crit Care. 2020 Nov 16;24(1):647
pubmed: 33198786
Viruses. 2016 Jul 04;8(7):
pubmed: 27384578
J Virol. 2020 Oct 14;94(21):
pubmed: 32788194
MMWR Morb Mortal Wkly Rep. 2021 Aug 06;70(31):1059-1062
pubmed: 34351882
EBioMedicine. 2020 Aug;58:102887
pubmed: 32736307
Vaccine. 2010 Dec 10;29(1):17-25
pubmed: 21034822
Vaccines (Basel). 2020 Nov 13;8(4):
pubmed: 33202961
JAMA. 2020 Apr 28;323(16):1610-1612
pubmed: 32129805
One Health. 2020 Feb 24;9:100124
pubmed: 32195311
Nature. 2020 Apr;580(7805):578-580
pubmed: 32273621
Emerg Infect Dis. 2020 Jun;26(6):1320-1323
pubmed: 32125269
Nat Commun. 2020 Mar 27;11(1):1620
pubmed: 32221306
J Virol. 2007 Nov;81(21):11560-8
pubmed: 17715243
Virol J. 2020 Jan 31;17(1):16
pubmed: 32005267
Int J Lab Hematol. 2021 Apr;43(2):160-168
pubmed: 33264492
Adv Exp Med Biol. 2017;972:87-101
pubmed: 27722960
J Virol. 2000 Jun;74(11):5101-7
pubmed: 10799584
Biochim Biophys Acta. 1989 Nov 30;999(2):171-5
pubmed: 2597705
N Engl J Med. 1964 Sep 24;271:645-51
pubmed: 14170843
N Engl J Med. 2021 Oct 14;385(16):1474-1484
pubmed: 34320281
Cancer Detect Prev. 1993;17(6):619-27
pubmed: 8275514
Trends Immunol. 2016 Dec;37(12):844-854
pubmed: 27793570
Lancet. 2020 Nov 7;396(10261):1467-1469
pubmed: 32971042
J Med Virol. 2020 Sep;92(9):1511-1517
pubmed: 32437052
Nature. 2020 Aug;584(7819):22-25
pubmed: 32760050
Nature. 2020 Jun;582(7813):467-468
pubmed: 32546810
Eur J Clin Microbiol Infect Dis. 2004 Jan;23(1):1-6
pubmed: 14663646