Bioymifi, a novel mimetic of TNF-related apoptosis-induced ligand (TRAIL), stimulates eryptosis.
Calcium
/ metabolism
Eosinophils
/ drug effects
Eryptosis
/ drug effects
Erythrocytes
/ drug effects
Hemolysis
/ drug effects
Humans
Phthalimides
/ toxicity
Reactive Oxygen Species
/ metabolism
Receptors, TNF-Related Apoptosis-Inducing Ligand
/ agonists
Thiazolidines
/ toxicity
p38 Mitogen-Activated Protein Kinases
/ physiology
Bioymifi
Calcium
Chemotherapy
Death receptor
Eryptosis
Hemolysis
Journal
Medical oncology (Northwood, London, England)
ISSN: 1559-131X
Titre abrégé: Med Oncol
Pays: United States
ID NLM: 9435512
Informations de publication
Date de publication:
11 Oct 2021
11 Oct 2021
Historique:
received:
14
08
2021
accepted:
21
09
2021
entrez:
11
10
2021
pubmed:
12
10
2021
medline:
8
2
2022
Statut:
epublish
Résumé
Tumor necrosis factor-related apoptosis-induced ligand (TRAIL) is a cytokine that initiates apoptosis upon binding to death receptor 5 (DR5) on cancer cells. Small molecule TRAIL mimetics have therefore been investigated as promising chemotherapeutic agents. Since anemia of chemotherapy is common, our goal is to investigate the hemolytic and eryptotic properties of novel DR5 agonist bioymifi (BMF) and identify the underlying molecular mechanisms. Whole blood (WB) was stimulated with 100 μM of BMF, whereas red blood cells (RBCs) were treated with 10-100 μM of BMF for 24 h at 37 °C. WB was analyzed for RBC, leukocyte, and platelet indices, while RBCs were examined for hemolysis by light absorbance of free hemoglobin, membrane scrambling by Annexin V-FITC, calcium by Fluo4/AM, cellular morphology by light scatter, and oxidative stress by 2',7'-dichlorodihydrofluorescein diacetate (H
Identifiants
pubmed: 34633592
doi: 10.1007/s12032-021-01589-5
pii: 10.1007/s12032-021-01589-5
doi:
Substances chimiques
5-(5-((3-(4-bromophenyl)-2-imino-4-oxothiazolidin-5-ylidene)methyl)furan-2-yl)isoindoline-1,3-dione
0
Phthalimides
0
Reactive Oxygen Species
0
Receptors, TNF-Related Apoptosis-Inducing Ligand
0
Thiazolidines
0
p38 Mitogen-Activated Protein Kinases
EC 2.7.11.24
Calcium
SY7Q814VUP
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
138Subventions
Organisme : Deanship of Scientific Research, King Saud University
ID : Research Group (RG-1441-335)
Informations de copyright
© 2021. Springer Science+Business Media, LLC, part of Springer Nature.
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