Trace elements in whole blood in the general population in Trøndelag County, Norway: The HUNT3 Survey.

Humans Linear Models Mercury Spectrum Analysis Surveys and Questionnaires Trace Elements / analysis
Biomonitoring HR-ICP-MS HUNT Population-based study Trace elements Whole blood

Journal

The Science of the total environment
ISSN: 1879-1026
Titre abrégé: Sci Total Environ
Pays: Netherlands
ID NLM: 0330500

Informations de publication

Date de publication:
01 Feb 2022
Historique:
received: 30 06 2021
revised: 04 10 2021
accepted: 04 10 2021
pubmed: 12 10 2021
medline: 15 12 2021
entrez: 11 10 2021
Statut: ppublish

Résumé

Biomonitoring of a cohort within a large health survey can provide reliable information on trace element status. The main aims of this study were 1) to determine the concentrations of 28 trace elements in whole blood samples from the general population of the Nord-Trøndelag region, Norway, and 2) to investigate how trace element concentrations vary with geographical area, lifestyle, and socio-demographic factors. Whole blood samples were collected in the third survey of the Trøndelag Health Survey (HUNT3), a large population-based study in Norway. In total, 1011 whole blood samples from individuals aged 20-91 years were analyzed using high resolution inductively coupled plasma-mass spectrometry (HR-ICP-MS). We compared trace element concentrations (As, B, Be, Br, Ca, Cd, Cr, Cs, Cu, Ga, Au, In, Fe, Pb, Hg, Tl, Mg, Mn, Mo, Ni, Rb, Sc, Se, Ag, Sr, Sn, W and Zn) between three geographical areas (coastal, fjord/town, inland/mountain) using multivariable linear regression and assessed differences in trace element concentrations with socio-demographic and lifestyle factors using general linear models. Trace element concentrations were generally comparable to levels reported in other recent studies and suggest low exposure to toxic trace elements in the region. We found geographical differences in concentrations of 19 trace elements. As, Br, Hg, and Se concentrations were higher on the coast compared to the fjord/town and inland/mountain areas, suggesting that the marine environment is an important source of exposure for these trace elements. In addition, socio-demographic and lifestyle characteristics, particularly age and sex, were associated with differences in trace element concentrations. We report concentrations of 28 trace elements in the general population of a rural region with low exposure to pollution. Whole blood concentrations of trace elements varied with geographical area, the participants' lifestyle, and socio-demographic characteristics, highlighting the importance of considering these factors when evaluating trace element status in a population.

Sections du résumé

BACKGROUND BACKGROUND
Biomonitoring of a cohort within a large health survey can provide reliable information on trace element status. The main aims of this study were 1) to determine the concentrations of 28 trace elements in whole blood samples from the general population of the Nord-Trøndelag region, Norway, and 2) to investigate how trace element concentrations vary with geographical area, lifestyle, and socio-demographic factors.
METHODS METHODS
Whole blood samples were collected in the third survey of the Trøndelag Health Survey (HUNT3), a large population-based study in Norway. In total, 1011 whole blood samples from individuals aged 20-91 years were analyzed using high resolution inductively coupled plasma-mass spectrometry (HR-ICP-MS). We compared trace element concentrations (As, B, Be, Br, Ca, Cd, Cr, Cs, Cu, Ga, Au, In, Fe, Pb, Hg, Tl, Mg, Mn, Mo, Ni, Rb, Sc, Se, Ag, Sr, Sn, W and Zn) between three geographical areas (coastal, fjord/town, inland/mountain) using multivariable linear regression and assessed differences in trace element concentrations with socio-demographic and lifestyle factors using general linear models.
RESULTS RESULTS
Trace element concentrations were generally comparable to levels reported in other recent studies and suggest low exposure to toxic trace elements in the region. We found geographical differences in concentrations of 19 trace elements. As, Br, Hg, and Se concentrations were higher on the coast compared to the fjord/town and inland/mountain areas, suggesting that the marine environment is an important source of exposure for these trace elements. In addition, socio-demographic and lifestyle characteristics, particularly age and sex, were associated with differences in trace element concentrations.
CONCLUSIONS CONCLUSIONS
We report concentrations of 28 trace elements in the general population of a rural region with low exposure to pollution. Whole blood concentrations of trace elements varied with geographical area, the participants' lifestyle, and socio-demographic characteristics, highlighting the importance of considering these factors when evaluating trace element status in a population.

Identifiants

DOI: 10.1016/j.scitotenv.2021.150875 PMID: 34634345
pubmed: 34634345
pii: S0048-9697(21)05953-2
doi: 10.1016/j.scitotenv.2021.150875
pii:
doi:

Substances chimiques

Trace Elements 0
Mercury FXS1BY2PGL

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

150875

Informations de copyright

Copyright © 2021 The Authors. Published by Elsevier B.V. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Auteurs

Anica Simić (A)

Department of Chemistry, NTNU, Norwegian University of Science and Technology, Trondheim, Norway. Electronic address: anica.simic@ntnu.no.

Ailin Falkmo Hansen (AF)

Department of Chemistry, NTNU, Norwegian University of Science and Technology, Trondheim, Norway; K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.

Tore Syversen (T)

Department of Neuroscience, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.

Syverin Lierhagen (S)

Department of Chemistry, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.

Tomasz Maciej Ciesielski (TM)

Department of Biology, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.

Pål Richard Romundstad (PR)

Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.

Kristian Midthjell (K)

HUNT Research Center, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Levanger, Norway.

Bjørn Olav Åsvold (BO)

Department of Chemistry, NTNU, Norwegian University of Science and Technology, Trondheim, Norway; HUNT Research Center, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Levanger, Norway; Department of Endocrinology, Clinic of Medicine, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway.

Trond Peder Flaten (TP)

Department of Chemistry, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Trace elements in whole blood in the general...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Analyse de régression › Modèles linéaires › Trace elements in whole blood in the general...
questionsmedicales.fr › Produits chimiques inorganiques › Métaux › Métaux lourds › Mercure › Trace elements in whole blood in the general...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Analyse spectrale › Trace elements in whole blood in the general...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Collecte de données › Enquêtes et questionnaires › Trace elements in whole blood in the general...
questionsmedicales.fr › Aliments et boissons › Aliments › Nutriments › Micronutriments › Oligoéléments › Trace elements in whole blood in the general...