An overview of the recent findings of cell-based therapies for the treatment and management of COVID-19.
Adoptive immunotherapy
COVID-19
SARS-CoV-2
T cell
Vaccine
Journal
International immunopharmacology
ISSN: 1878-1705
Titre abrégé: Int Immunopharmacol
Pays: Netherlands
ID NLM: 100965259
Informations de publication
Date de publication:
Dec 2021
Dec 2021
Historique:
received:
03
08
2021
revised:
19
09
2021
accepted:
03
10
2021
pubmed:
12
10
2021
medline:
21
12
2021
entrez:
11
10
2021
Statut:
ppublish
Résumé
The coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become a global pandemic taking the lives of millions. The virus itself not only invades and destroys the angiotensin-converting enzyme 2 (ACE2)-expressing cells of the lungs, kidneys, liver, etc. but also elicits a hyperinflammatory immune response, further damaging the tissue leading to acute respiratory distress syndrome (ARDS) and death. Although vaccines, as a prime example of active immunotherapy, have clearly disrupted the transmission of virus and reduced mortality, hospitalization, and burden of disease, other avenues of immunotherapy are also being explored. One such approach would be to adoptively transfer modified/unmodified immune cells to the critically ill. Here, we compiled and summarized the immunopathogenesis of SARS-CoV-2 and the recent preclinical and clinical data on the potential of cell-based therapies in the fight against COVID-19.
Identifiants
pubmed: 34634685
pii: S1567-5769(21)00862-6
doi: 10.1016/j.intimp.2021.108226
pmc: PMC8492917
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
108226Informations de copyright
Copyright © 2021 Elsevier B.V. All rights reserved.
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