Generation of a transgenic mouse embryonic stem cell line expressing Dnmt1

Animals Cell Line DNA (Cytosine-5-)-Methyltransferase 1 / genetics Hereditary Sensory and Autonomic Neuropathies / genetics Mice Mice, Transgenic Mouse Embryonic Stem Cells Mutation / genetics

Journal

Stem cell research
ISSN: 1876-7753
Titre abrégé: Stem Cell Res
Pays: England
ID NLM: 101316957

Informations de publication

Date de publication:
10 2021
Historique:
received: 14 08 2021
revised: 16 09 2021
accepted: 02 10 2021
pubmed: 12 10 2021
medline: 26 11 2021
entrez: 11 10 2021
Statut: ppublish

Résumé

DNMT1 Y495C is the most common mutation associated with hereditary sensory and autonomic neuropathy type 1E, and dementia. Here we employed non-homologous recombination and generated a mouse embryonic stem cell line carrying a transgene expressing DNMT1 Y495C mutation in the wild-type background. The resultant cell line, Dnmt1

Identifiants

DOI: 10.1016/j.scr.2021.102561 PMID: 34634759
pubmed: 34634759
pii: S1873-5061(21)00408-6
doi: 10.1016/j.scr.2021.102561
pii:
doi:

Substances chimiques

DNA (Cytosine-5-)-Methyltransferase 1 EC 2.1.1.37

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

102561

Informations de copyright

Copyright © 2021 The Author(s). Published by Elsevier B.V. All rights reserved.

Auteurs

Sumana Choudhury (S)

Molecular Biology and Genetics Laboratory, Department of Biological Sciences, Hyderabad, India.

K Naga Mohan (KN)

Molecular Biology and Genetics Laboratory, Department of Biological Sciences, Hyderabad, India; Centre for Human Disease Research, BITS Pilani Hyderabad Campus, Hyderabad, India. Electronic address: MohanKN@hyderabad.bits-pilani.ac.in.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Generation of a transgenic mouse embryonic...
questionsmedicales.fr › Cellules › Cellules cultivées › Lignée cellulaire › Generation of a transgenic mouse embryonic...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines nucléaires › Protéines liant le poly-adp-ribose › DNA (Cytosine-5-)-methyltransferase 1 › Generation of a transgenic mouse embryonic...
questionsmedicales.fr › Malformations et maladies congénitales, héréditaires et néonatales › Maladies génétiques congénitales › Maladies neurodégénératives héréditaires › Neuropathies héréditaires sensitives et autonomes › Generation of a transgenic mouse embryonic...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Generation of a transgenic mouse embryonic...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Generation of a transgenic mouse embryonic...
questionsmedicales.fr › Cellules › Cellules souches › Cellules souches pluripotentes › Cellules souches embryonnaires › Cellules souches embryonnaires de souris › Generation of a transgenic mouse embryonic...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Mutation › Generation of a transgenic mouse embryonic...